Application of 952511-48-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 952511-48-7 as follows.
Example 46N4-(5-Cyclopropyl- 1 H-pyrazol-3-yl)-N2-methyl-N2-((4-methyl- 1 H-b enzo [d] imidazol-5- yl)methyl)pyrimidine-2,4-diamine (1-95)step 1 : To a solution of 5-bromo-4-methyl-lH-benzo[d]imidazole (1.0 g, 4.74 mmol, CASRN 952511-48- 7) and 3,4-dihydro-2H-pyran (2.0 g, 23.70 mmol) in THF (10 mL) was added / TsOH-H20 (90 mg, 0.47 mmol). The mixture was heated at 80 °C overnight, cooled and the solvent was removed in vacuo. The residue was diluted with DCM (100 mL) and water (50 mL). The organic layer was separated, dried (MgSO i), filtered and concentrated to dryness in vacuo. The crude product was purified by Si02 chromatography eluting with a petroleum ether/EtOAc gradient (10 to 50percent EtOAc) to afford 800 mg (57percent) of 5-bromo-4-methyl-l -(tetrahydro- 2H-pyran-2-yl)-lH-benzo[d]imidazole (254) as light yellow solid: MS (ESI) m/z = 295.1 [M+l]+.
According to the analysis of related databases, 952511-48-7, the application of this compound in the production field has become more and more popular.