Category: 939-70-8

Synthetic Route of 939-70-8, The chemical industry reduces the impact on the environment during synthesis 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, I believe this compound will play a more active role in future production and life.

General procedure: A 10%solution of NaOH (5 ml) in EtOH was added to a solutionof 2-acetylbenzimidazole (4) (1.6 g, 0.01 mol) in absoluteEtOH (20 ml) at 0C with stirring. Then the solution of anaromatic aldehyde (0.01 mol) in absolute EtOH (10 ml)was added dropwise. The reaction mixture was stirred for12 h at room temperature. After completion of reaction(monitored by TLC), the reaction mixture was poured ontocrushed ice. The separated solid was filtered off, washedwith water, and dried. The residue was purified by columnchromatography (silica gel, eluent 10% ethyl acetate inpetroleum ether) to afford pure benzimidazole-derived chalcone 5a-m.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Benzo[d]imidazol-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Meshram, Gangadhar A.; Vala, Vipul A.; Chemistry of Heterocyclic Compounds; vol. 51; 1; (2015); p. 44 – 50; Khim. Geterotsikl. Soedin.; vol. 51; 1; (2015); p. 44 – 50,7;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, molecular formula is C9H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 939-70-8

General procedure: A 10%solution of NaOH (5 ml) in EtOH was added to a solutionof 2-acetylbenzimidazole (4) (1.6 g, 0.01 mol) in absoluteEtOH (20 ml) at 0C with stirring. Then the solution of anaromatic aldehyde (0.01 mol) in absolute EtOH (10 ml)was added dropwise. The reaction mixture was stirred for12 h at room temperature. After completion of reaction(monitored by TLC), the reaction mixture was poured ontocrushed ice. The separated solid was filtered off, washedwith water, and dried. The residue was purified by columnchromatography (silica gel, eluent 10% ethyl acetate inpetroleum ether) to afford pure benzimidazole-derived chalcone 5a-m.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 939-70-8, its application will become more common.

Reference:
Article; Meshram, Gangadhar A.; Vala, Vipul A.; Chemistry of Heterocyclic Compounds; vol. 51; 1; (2015); p. 44 – 50; Khim. Geterotsikl. Soedin.; vol. 51; 1; (2015); p. 44 – 50,7;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 939-70-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 939-70-8 as follows.

General procedure: To the solution of 2-acetyl benzimidazole 1 (0.01 mol) in MeOH (20 mL) was added 10% aqueous NaOH (2 mL) at 0C with stirring. Then, the solution of aromatic aldehydes (0.01 mol) in MeOH was added drop-wise. The reaction mixture was magnetically stirred for 12 h. After completion of the reaction (monitored by TLC) the reaction mixture was poured over crushed ice. The separated solid was filtered, washed with water and dried. The residue was purified by column chromatography (silica gel with 10% ethyl acetate in petroleum ether) to afford pure benzimidazole derived chalcone 2a-m.

According to the analysis of related databases, 939-70-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Meshram, Gangadhar A; Vala, Vipul A.; Wagh, Pramod A.; Deshpande, Shruti S.; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 55B; 5; (2016); p. 613 – 623;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 939-70-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 1-(1H-benzo [d] imidazol-2-yl)ethanone (2) (0.01 mol) in ethanol (60 ml),benzaldehyde (0.01 mol) and a few drops of glacialacetic acid were added and the mixture refluxed for10 hr. It was then cooled concentrated and pouredinto crushed ice and filtered. The solid thus obtainedwas purified by recrystallizaton from ethanol.

The chemical industry reduces the impact on the environment during synthesis 1-(1H-Benzo[d]imidazol-2-yl)ethanone. I believe this compound will play a more active role in future production and life.

Reference:
Article; Bhaskar; Bharahmeswari; Indian Journal of Heterocyclic Chemistry; vol. 23; 2; (2013); p. 207 – 212;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 939-70-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 939-70-8 as follows.

General procedure: A solution of 2-acetyl-benzimidazole 4(3.2 g, 20 mmol) and the diversely substituted aromatic aldehydes5a-h (24 mmol) in 40 ml of absolute methanol were taken in a flask.Potassium hydroxide (8.0 g, 142.6 mmol) was added and the reactionmixture was stirred for 24 h at room temperature under TLCmonitoring. The mixture was then poured into crushed ice water.The product obtained is filtered and washed with distilled waterand finally recrystallized from methanol.

According to the analysis of related databases, 939-70-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Djemoui, Amar; Naouri, Abdelkader; Ouahrani, Mohammed Ridha; Djemoui, Djamila; Lahcene, Souli; Lahrech, Mokhtar Boualem; Boukenna, Leila; Albuquerque, Helio M.T.; Saher, Liza; Rocha, Djenisa H.A.; Monteiro, Fatima Liliana; Helguero, Luisa A.; Bachari, Khaldoun; Talhi, Oualid; Silva, Artur M.S.; Journal of Molecular Structure; vol. 1204; (2020);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem