Category: 939-70-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(1H-Benzo[d]imidazol-2-yl)ethanone

General procedure: To a solution of 2-acetylbenzimidazole 3 (0.800 g, 5.00 mmol) in ethanol (50 mL) were added 60% aqueous potassium hydroxide (15 mL) and 4-fluorobenzaldehyde (0.620 g, 5 mmol) at 0 C with stirring. The reaction mixture was stirred at room temperature until complete consumption of starting material (monitored by TLC, petroleum ether/chloroform, 1/3, V/V). The crushed ice and diluted hydrochloric acid solution were added for total precipitation of the yellow solid (0.846 g), which were obtained by vacuum filtration and then recrystallized in ethanol.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Liu, Han-Bo; Gao, Wei-Wei; Tangadanchu, Vijai Kumar Reddy; Zhou, Cheng-He; Geng, Rong-Xia; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 66 – 84;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 939-70-8,Some common heterocyclic compound, 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, molecular formula is C9H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 10%solution of NaOH (5 ml) in EtOH was added to a solutionof 2-acetylbenzimidazole (4) (1.6 g, 0.01 mol) in absoluteEtOH (20 ml) at 0C with stirring. Then the solution of anaromatic aldehyde (0.01 mol) in absolute EtOH (10 ml)was added dropwise. The reaction mixture was stirred for12 h at room temperature. After completion of reaction(monitored by TLC), the reaction mixture was poured ontocrushed ice. The separated solid was filtered off, washedwith water, and dried. The residue was purified by columnchromatography (silica gel, eluent 10% ethyl acetate inpetroleum ether) to afford pure benzimidazole-derived chalcone 5a-m.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(1H-Benzo[d]imidazol-2-yl)ethanone, its application will become more common.

Reference:
Article; Meshram, Gangadhar A.; Vala, Vipul A.; Chemistry of Heterocyclic Compounds; vol. 51; 1; (2015); p. 44 – 50; Khim. Geterotsikl. Soedin.; vol. 51; 1; (2015); p. 44 – 50,7;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 939-70-8, The chemical industry reduces the impact on the environment during synthesis 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, I believe this compound will play a more active role in future production and life.

General procedure: A 10%solution of NaOH (5 ml) in EtOH was added to a solutionof 2-acetylbenzimidazole (4) (1.6 g, 0.01 mol) in absoluteEtOH (20 ml) at 0C with stirring. Then the solution of anaromatic aldehyde (0.01 mol) in absolute EtOH (10 ml)was added dropwise. The reaction mixture was stirred for12 h at room temperature. After completion of reaction(monitored by TLC), the reaction mixture was poured ontocrushed ice. The separated solid was filtered off, washedwith water, and dried. The residue was purified by columnchromatography (silica gel, eluent 10% ethyl acetate inpetroleum ether) to afford pure benzimidazole-derived chalcone 5a-m.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Benzo[d]imidazol-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Meshram, Gangadhar A.; Vala, Vipul A.; Chemistry of Heterocyclic Compounds; vol. 51; 1; (2015); p. 44 – 50; Khim. Geterotsikl. Soedin.; vol. 51; 1; (2015); p. 44 – 50,7;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 939-70-8, The chemical industry reduces the impact on the environment during synthesis 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, I believe this compound will play a more active role in future production and life.

General procedure: A 10%solution of NaOH (5 ml) in EtOH was added to a solutionof 2-acetylbenzimidazole (4) (1.6 g, 0.01 mol) in absoluteEtOH (20 ml) at 0C with stirring. Then the solution of anaromatic aldehyde (0.01 mol) in absolute EtOH (10 ml)was added dropwise. The reaction mixture was stirred for12 h at room temperature. After completion of reaction(monitored by TLC), the reaction mixture was poured ontocrushed ice. The separated solid was filtered off, washedwith water, and dried. The residue was purified by columnchromatography (silica gel, eluent 10% ethyl acetate inpetroleum ether) to afford pure benzimidazole-derived chalcone 5a-m.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Benzo[d]imidazol-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Meshram, Gangadhar A.; Vala, Vipul A.; Chemistry of Heterocyclic Compounds; vol. 51; 1; (2015); p. 44 – 50; Khim. Geterotsikl. Soedin.; vol. 51; 1; (2015); p. 44 – 50,7;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, molecular formula is C9H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-(1H-Benzo[d]imidazol-2-yl)ethanone

General procedure: To the solution of 2-acetyl benzimidazole 1 (0.01 mol) in MeOH (20 mL) was added 10% aqueous NaOH (2 mL) at 0C with stirring. Then, the solution of aromatic aldehydes (0.01 mol) in MeOH was added drop-wise. The reaction mixture was magnetically stirred for 12 h. After completion of the reaction (monitored by TLC) the reaction mixture was poured over crushed ice. The separated solid was filtered, washed with water and dried. The residue was purified by column chromatography (silica gel with 10% ethyl acetate in petroleum ether) to afford pure benzimidazole derived chalcone 2a-m.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 939-70-8, its application will become more common.

Reference:
Article; Meshram, Gangadhar A; Vala, Vipul A.; Wagh, Pramod A.; Deshpande, Shruti S.; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 55B; 5; (2016); p. 613 – 623;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 939-70-8, A common heterocyclic compound, 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, molecular formula is C9H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Various o-substituted anilines (0.05 mol) and lactic acids (3.75 mL, 0.05 mol) were dissolved in 20 mL of HCl (4 M). The mixture was heated under reflux for 1.5 h. After cooling to room temperature, the reaction mixture was poured into water. Next, the pH was adjusted to 10-11 with ammonia. The mixture was filtered, and the residue was recrystallized from water to give intermediates 1b-3b. Next, 1b-3b (0.02 mol) were each dissolved in 15 mL of acetic acid. When the mixture was heated to 90 C, chromium trioxide solution was added. The reaction mixture was stirred at 105C for 30 min. After cooling to room temperature, the reaction mixture was poured into water (1 L) and then extracted by ethyl acetate (EtOAc). The organic layers were combined, dried with MgSO4, filtered and then concentrated under reduced pressure. The residue was recrystallized from toluene to give the intermediates 1c-3c. Last, 1c-3c (0.02 mol) and 8 mL of a 10% NaOH aqueous solution were dissolved in 20 mL of ethanol. The reaction mixture became a clear red solution. Next, various substituted aromatic aldehydes (0.02 mol) were added. After stirring for 5 h, the mixture was filtered, and the residue was purified by column chromatography (EtOAc: hexane = 1:5) to give the target compounds A1-A13, B1-B3 and C1-C3.

The synthetic route of 939-70-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wu, Lin-Tao; Jiang, Zhi; Shen, Jia-Jia; Yi, Hong; Zhan, Yue-Chen; Sha, Ming-Quan; Wang, Zhen; Xue, Si-Tu; Li, Zhuo-Rong; European Journal of Medicinal Chemistry; vol. 114; (2016); p. 328 – 336;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939-70-8, name: 1-(1H-Benzo[d]imidazol-2-yl)ethanone

Synthesis of target compound Y-0: 2-acetylbenzimidazole (1 mmol) at 0 CTo a solution of ethanol (10 mL) was added 60% aqueous potassium hydroxide solution (3 mL) and benzaldehyde (1 mmol),Stir at room temperature until the reaction is complete. TLC monitors the progress of the reaction.After the reaction is complete, add crushed ice and dilute hydrochloric acid solution, adjust the pH to form a precipitate,The crude extract was dried by filtration and purified by column chromatography to obtain the target compound Y-0.(Synthesis method see literature: European Journal of Medicinal Chemistry 143 (2018) 66-84) Yield: 62.6%;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Lanzhou University; Liu Yingqian; Wang Renxuan; Li Juncai; Yang Chengjie; Chen Yongjia; Peng Jingwen; Yin Xiaodan; Yan Yinfang; (10 pag.)CN110839636; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, A new synthetic method of this compound is introduced below., Recommanded Product: 939-70-8

General procedure: To a solution of 2-acetylbenzimidazole 3 (0.800 g, 5.00 mmol) in ethanol (50 mL) were added 60% aqueous potassium hydroxide (15 mL) and 4-fluorobenzaldehyde (0.620 g, 5 mmol) at 0 C with stirring. The reaction mixture was stirred at room temperature until complete consumption of starting material (monitored by TLC, petroleum ether/chloroform, 1/3, V/V). The crushed ice and diluted hydrochloric acid solution were added for total precipitation of the yellow solid (0.846 g), which were obtained by vacuum filtration and then recrystallized in ethanol.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Liu, Han-Bo; Gao, Wei-Wei; Tangadanchu, Vijai Kumar Reddy; Zhou, Cheng-He; Geng, Rong-Xia; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 66 – 84;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 939-70-8,Some common heterocyclic compound, 939-70-8, name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, molecular formula is C9H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 1-(1H-benzo [d] imidazol-2-yl)ethanone (2) (0.01 mol) in ethanol (60 ml),benzaldehyde (0.01 mol) and a few drops of glacialacetic acid were added and the mixture refluxed for10 hr. It was then cooled concentrated and pouredinto crushed ice and filtered. The solid thus obtainedwas purified by recrystallizaton from ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(1H-Benzo[d]imidazol-2-yl)ethanone, its application will become more common.

Reference:
Article; Bhaskar; Bharahmeswari; Indian Journal of Heterocyclic Chemistry; vol. 23; 2; (2013); p. 207 – 212;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 939-70-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 939-70-8 name is 1-(1H-Benzo[d]imidazol-2-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 1-(1H-benzo [d] imidazol-2-yl)ethanone (2) (0.01 mol) in ethanol (60 ml),benzaldehyde (0.01 mol) and a few drops of glacialacetic acid were added and the mixture refluxed for10 hr. It was then cooled concentrated and pouredinto crushed ice and filtered. The solid thus obtainedwas purified by recrystallizaton from ethanol.1 H NMR (400 MHz, DMSO-d6): delta 6.81 (d, 1H,J=10.2 Hz), 6.98-7.20 (m, 5H), 7.24 (d, 1H, J=10.2Hz), 7.42 (m, 4H), 10.24 (brs, 1H). Mass [M+H], 249.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Benzo[d]imidazol-2-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Article; Bhaskar; Bharahmeswari; Indian Journal of Heterocyclic Chemistry; vol. 23; 2; (2013); p. 207 – 212;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem