Application of 937013-66-6, The chemical industry reduces the impact on the environment during synthesis 937013-66-6, name is 2-(3-Bromophenyl)-1H-imidazole, I believe this compound will play a more active role in future production and life.
General procedure: A mixture of 4-bromobenzaldehyde (2.78 g; 15.0 mmol), [3-(aminocarbonyl)-phenyl]boronic acid (2.72 g; 16.5 mmol), PdCl2(dppf).CH2Cl2(0.306 g; 0.38 mmol), DME (25 mL) and Na2CO3(25 mL of a 2M solution) was sparged 20 min with N2and heated under reflux for 90 min (consumption of aryl bromide observed by LC/MS). Upon cooling, the mixture was partitioned between EtOAc/H2O, layers were separated, and the aqueous layer was extracted with EtOAc (¡Á2). Combined organics were washed (H2O, brine), dried over Na2SO4and concentrated in vacuo. The residue was purified by flash chromatography (EtOAc/hexanes), affording the title compound as a tan solid. Used IV-21 and 4- formylphenyl boronic acid Note 1, 2. Note 1 Used 4:1 v/v PhMe/EtOH as organic cosolvents (instead of DME).Note 2 Used Pd(PPh3)4as catalyst (instead of PdCl2(dppf).CH2Cl2).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Bromophenyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SMITHKLINE BEECHAM CORP; COWAN, D. J; LARKIN, A. L.; ZHANG, CUNYU; MUSSO, D. L.; GREEN, G. M.; CADILLA, R.; SPEARING, P.K.; BISHOP, M. J.; SPEAKE, J. D.; (219 pag.)CN102516115; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem