Category: 93668-43-0

Electric Literature of 93668-43-0, These common heterocyclic compound, 93668-43-0, name is 2-(1H-Imidazol-1-yl)ethanamine dihydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In like manner, the reaction of 1H-imidazole-1-ethaneamine dihydrochloride with 2-furoyl chloride by the procedure of Example 1 provided N-[2-(1H-imidazol-1-yl)ethyl]-2-furanecarboxamide, m.p. 131-133 C.

Statistics shows that 2-(1H-Imidazol-1-yl)ethanamine dihydrochloride is playing an increasingly important role. we look forward to future research findings about 93668-43-0.

Reference:
Patent; American Cyanamid Company; US4489089; (1984); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

93668-43-0, name is 2-(1H-Imidazol-1-yl)ethanamine dihydrochloride, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-(1H-Imidazol-1-yl)ethanamine dihydrochloride

To a stirred solution of 2-(1H-imidazol-1-yl)ethan-1-amine dihydrochloride (commercially available from Sigma Aldrich) (600 mg, 3.25 mmol) in DMF (5 mL) was added DIPEA (2.2 mL, 13.0 mmol) at 0 C. After 15 min, tert-butyl N-[(1E)-{[(tert-butoxy)carbonyl]amino}(1H-pyrazol-1-yl)methylidene]carbamate (commercially available from Sigma Aldrich) (1.1 g, 3.58 mmol) was added at the same temperature and allowed to stir at RT for 16 h. N2 gas was bubbled into the reaction mixture for 15 minutes then water was added to the crude product followed by stirring for 5 minutes. The resulting precipitate was filtered, washed with water (2 x 10 mL) and dried under high vacuum affording a white solid (800 mg, 71%). M/z 354.2 [M+H]+

The synthetic route of 93668-43-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Antabio SAS; DAVIES, David; LEIRIS, Simon; (56 pag.)EP3572411; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 93668-43-0,Some common heterocyclic compound, 93668-43-0, name is 2-(1H-Imidazol-1-yl)ethanamine dihydrochloride, molecular formula is C5H11Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 1.47 g. portion of 1H-imidazole-1-ethanamine dihydrochloride was reacted with 3-chloro-benzo[b]thiophene-2-carbonyl chloride as described in Example 1, giving 0.75 g. of the desired product, m.p. 132-134 C.

The synthetic route of 93668-43-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; American Cyanamid Company; US4489089; (1984); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem