Category: 934-32-7

Electric Literature of 934-32-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 934-32-7 name is 1H-Benzo[d]imidazol-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To the mixture of 2-aminobenzimidazole (1 mmol), malononitrile (1 mmol) and 4-fluorobenzaldehyde (1 mmol) in ethylene glycol (5 mL), SSA (42.6 mg, 0.11 mol %) wasadded. The mixture was heated at 50 C for 5 minutes. After completion of the reaction(TLC), 10 mL EtOAc was added to the reaction mixture and the catalyst was recovered by filtration. The organic layer was dried over Na2SO4; the solvent was evaporated and purified by recrystallization from ethanol to give compounds 1b. Yield 87%

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Benzo[d]imidazol-2-amine, and friends who are interested can also refer to it.

Reference:
Article; Basyouni, Wahid M.; Abbas, Samir Y.; Abdelazeem, Nagwa M.; El-Bayouki, Khairy A. M.; El-Kady, Mohamed Y.; Synthetic Communications; vol. 49; 22; (2019); p. 3112 – 3120;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 934-32-7, name is 1H-Benzo[d]imidazol-2-amine, A new synthetic method of this compound is introduced below., SDS of cas: 934-32-7

General procedure: A mixture of ethyl acetoacetate and/or acetylacetone (1 mmol) or malononitrile(1.1 mmol), 2-aminobenzimidazole (1 mmol), aldehyde (1 mmol) and [PVPH]ClO (30 mg, 6.84 mol %) was heated at 100 C in an oil bath for the appropriate time.After completion of the reaction [monitored by thin layer chromatography (TLC): nhexane:ethyl acetate (3:1)], the reaction mixture was cooled to room temperatureand EtOH (5 mL) was added to it and filtered to separate the catalyst. Afterevaporation of the solvent from the filtrate, the crude solid product wasrecrystallized from ethanol to obtain pure A or B products.The spectral [IR, proton ( 1H) NMR and 13C NMR] data of new compounds arepresented below.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Abedini, Masoumeh; Shirini, Farhad; Mousapour, Maryam; Goli Jolodar, Omid; Research on Chemical Intermediates; vol. 42; 7; (2016); p. 6221 – 6229;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 934-32-7, name is 1H-Benzo[d]imidazol-2-amine belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H7N3

General procedure: A mixture of aldehyde (1 mmol), 2-amino benzimidazole (1 mmol), and malononitrile (1 mmol) in PEG-400 (4 ml) and water (1 ml) solution were refluxed for 6-8 h. The progress of reaction was monitored by TLC using petroleum ether-ethyl acetate (6:4) as a solvent system. After completion of the reaction, 200 ml water was added and the solution was stirred for 2-3 h, the solid obtained was filtered to give the corresponding product with high purity without the need of column chromatography for further purification.

The synthetic route of 934-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Survase, Dattatray; Bandgar, Babasaheb; Helavi, Vasant; Synthetic Communications; vol. 47; 7; (2017); p. 680 – 687;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 934-32-7, name is 1H-Benzo[d]imidazol-2-amine belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: imidazoles-derivatives

(0851) The reaction is carried out as described in example 2, except that 1,3-dibromo-2-fluoro-benzene is used instead of 1,4-dibromo-2-fluoro-benzene. 1H NMR (400 MHz, CDCl3): ^ = 7.81-7.89 (m, 4H), 7.57-7.67 (m.4H), 7.46-7.50 (m, 1H), 7.36- 7.44 (m, 2H), 7.20 (t, 1H).

The synthetic route of 934-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SCHAeFER, Thomas; KAWAMURA, Masahiro; NAGASHIMA, Hideaki; (320 pag.)WO2017/56053; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 934-32-7, name is 1H-Benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 934-32-7, Recommanded Product: 934-32-7

General procedure: A mixture of aromaticaldehyde (1.0 mmol) and dimedone(1.0 mmol) with 2-aminobenzimidazole or 3-amino-1,2,4-triazole (1.0 mmol) was stirred in acetic acid (5 mL) at 60 Cfor the appropriate time (Tables 3, 4). The progress of thereaction was monitored by TLC. After completion of thereaction, a thick precipitate was obtained. The solid productwas filtered off and washed with acetic acid (3 × 2 mL) togive the pure products 4 and 6, and subsequently dried in air.The pure products were characterized by conventional spectroscopicmethods. Physical and spectral data for the compounds,4b, 4c, 4h, 4j, 6a, 6c, and 6h are represented below:

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Benzo[d]imidazol-2-amine, and friends who are interested can also refer to it.

934-32-7, name is 1H-Benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 934-32-7

General procedure: Amine (1 mmol) was added to the mixture of (Boc)2O (1 mmol) and DSIMHS (6.5 mg, ~ 0.02 mmol) with constant stirring at room temperature under solvent-free conditions. After completion of the reaction (monitored by TLC), ethyl acetate (3 × 5 mL) was added to the reaction mixture and the catalyst was decanted and washed with ethyl acetate (2 × 5 mL) and dried. The product was purified by column chromatography, using ethyl acetate-petroleum ether (2:8) eluent.

The synthetic route of 934-32-7 has been constantly updated, and we look forward to future research findings.

Related Products of 934-32-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 934-32-7 name is 1H-Benzo[d]imidazol-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 2-aminobenzimidazole 7 (1.33 g, 10.0 mmol), 10.0 mmol of the proper alkyl halide, 1.0 g of finely powdered KOH mixed with 2.0 g of anhydrous K2CO3 and acetone (50 mL) was heated at reflux for 3 h, with stirring. The solvent was removed in vacuo and the residue was partitioned between water (100 mL) and CH2Cl2 (100 mL), and the aqueous phase was further extracted twice with CH2Cl2. The combined extracts, dried over anhydrous Na2SO4, after removal of solvent afforded an oily or solid residue which was treated with a small amount of ethyl ether to give compounds 8a-e,l-o as whitish solids which were crystallized from the proper solvent. Only in the case of compound 8f, a preliminary purification by column chromatography [SiO2/ethyl acetate-acetone (1:1)] was necessary to obtain a crystalline compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Benzo[d]imidazol-2-amine, and friends who are interested can also refer to it.

Reference:
Article; Di Braccio, Mario; Grossi, Giancarlo; Signorello, Maria Grazia; Leoncini, Giuliana; Cichero, Elena; Fossa, Paola; Alfei, Silvana; Damonte, Gianluca; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 564 – 578;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In an article, author is KHANRA, TK, once mentioned the application of 934-32-7, Quality Control of 1H-Benzo[d]imidazol-2-amine, Name is 1H-Benzo[d]imidazol-2-amine, molecular formula is C7H7N3, molecular weight is 133.15, MDL number is MFCD00005596, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

NEW ACCELERATOR-CUM-ANTIOXIDANTS FOR CHLOROPRENE RUBBER

2-Mercaptoimidazole (MI), N-methyl-2-mercaptoimidazole (MMI), 2-mercaptobenzimidazole (MBI), 5-methyl-2-mercaptobenzimidazole (MMBI) and 5-nitro-2-mercaptobenzimidazole (NMBI) have been fried as the crosslinking agent for Neoprene W. Apart from the curing ability these imidazole derivatives have also shown antioxidant properties. 1-(N-oxydiethylene thiocarbamyl)-2-(N-oxydiethylene thio) benzimidazole (MBSPT), a novel dual function accelerator-cum-antioxidant for diene rubbers, has also been used in Neoprene W. The cure characteristics, physical properties of the vulcanizates and their aging behavior of stocks containing these imidazole derivatives, ethylene thiourea (Na-22) and MBSPT have been compared Some of the compounds viz MBSPT, MBI and MI may be prescribed as secondary accelerator-cum-antioxidants with some primary accelerator for filled neoprene rubber.

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Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Chen, Chung-Yu, once mentioned the application of 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, molecular formula is C7H7N3, molecular weight is 133.15, MDL number is MFCD00005596, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Computed Properties of C7H7N3.

Metal-Free, Acid-Promoted Synthesis of Imidazole Derivatives via a Multicomponent Reaction

An expedient and metal-free synthetic route has been developed for the construction of tri- and tetrasubstituted imidazole derivatives via acid promoted multicomponent reaction methodology. The reaction proceeded smoothly with a range of functionalities to produce the imidazole scaffolds in good to excellent yields.

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Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, molecular formula is C7H7N3, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Padalkar, Vikas S., once mentioned the new application about 934-32-7, Computed Properties of C7H7N3.

A Combined Experimental and DFT-TDDFT Study of the Excited-State Intramolecular Proton Transfer (ESIPT) of 2-(2′-Hydroxyphenyl) Imidazole Derivatives

We report a combined experimental and computational study of the effect of electron donor and acceptor groups on the excited state intramolecular proton transfer of 2-(2′-hydroxyphenyl) imidazole derivatives in solvents of different polarities. The changes in fluorescence properties, electronic transitions and energy levels are analyzed and discussed. The study was complemented using the Density Functional Theory (DFT)-Time Dependent DFT [B3LYP/6-31G(d)] computations. The calculated absorption and emission spectra of the imidazole derivatives are in good agreement with the experiments, thus allowing an assignment of the UV-vis spectra.

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