Category: 934-32-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 934-32-7 as follows. COA of Formula: C7H7N3

General procedure: A mixture of 2-aminobenzimidazole (1, 1 mmol), 4-bromobenzaldehyde (2a, 1 mmol), malononitrile (3,1 mmol) and p-TSA (10 mol%) was stirred at 80 8C undersolvent-free conditions for 30 min (Table 3, entry 1). Theprogress of the reaction was monitored by TLC. Aftercompletion of the reaction, the reaction mixture waswashed with water and ethanol, and the residue recrystallizedfrom ethanol to afford the pure product 4a (92%).

According to the analysis of related databases, 934-32-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Reddy, Mudumala Veeranarayana; Oh, Jeongsu; Jeong, Yeon Tae; Comptes Rendus Chimie; vol. 17; 5; (2014); p. 484 – 489;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 934-32-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 934-32-7 as follows.

General procedure: In a 50-mL round-bottomed flask, a mixture of 2-aminobenzimidazole 1 (2 mmol), aldehyde 2a-p (2 mmol), 1,3-cyclohexadione 3 (2 mmol), and deep eutectic solvent (5 mL) was stirred at 80 C for specified time (Scheme 2, Table 2). After reaction completion (monitored by TLC), the reaction mixture was cooled to room temperature then poured into crushed ice to obtain solid product, which was filtered, dried, and recrystallized from ethanol to afford pure product.

According to the analysis of related databases, 934-32-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Mahire, Vilas N.; Patel, Vijay E.; Mahulikar, Pramod P.; Research on Chemical Intermediates; vol. 43; 3; (2017); p. 1847 – 1861;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 934-32-7, name is 1H-Benzo[d]imidazol-2-amine, A new synthetic method of this compound is introduced below., Quality Control of 1H-Benzo[d]imidazol-2-amine

Step 1: 1-Methyl-1H-benzimidazol-2-amine To a solution of 2-aminobenzimidazole (3.0 g, 0.0225 mol) in acetone (30 ml) was added KOH (6.32 g, 0.112 mol) followed by methyl iodide (3.51 g, 0.025 mol) and stirred at room temperature for 10 min. The reaction mixture was diluted with ethyl acetate and the organic layer washed with water, brine and dried over anhydrous Na2SO4 to afford crude residue which was column purified to yield the desired product: 1H NMR (300 MHz, DMSO-d6) delta 3.47 (s, 3H), 6.34 (br s, 2H), 6.82-6.92 (m, 2H), 7.06-7.09 (m, 2H); ESI-MS (m/z) 148.49 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Glenmark Pharmaceuticals S.A.; US2009/286811; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 934-32-7, name is 1H-Benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 934-32-7, Safety of 1H-Benzo[d]imidazol-2-amine

General procedure: A solution of the selected heterocyclic starting material (1.00 mmol) in THF (10 mL) and a solutionof isopentyl nitrite (141 mg, 1.20 mmol) in THF (10 mL) were both pumped at a flow rate of 0.25 mLmin1 with a Vapourtech ?Easy MedChem V3? system, meeting at a PTFE T-piece and the outputflowing through a 10.0 mL coil reactor maintained at 120 C, giving a residence time of 20 min.The pressure of the system was maintained at 7 bar with a back-pressure regulator. For compoundswhere an isolated yield was reported: the output mixture was concentrated under reduced pressureto give an oil (or powder). The oil (or powder) was purified using column chromatography withvarious mixtures of ethyl acetate and hexane as the eluent, or by recrystallisation using methanol, togive isolated compounds that showed no impurities by NMR spectroscopy. For compounds where aconversion was reported (due to volatility of products), the output mixture was carefully concentratedunder a reduced pressure of 100 mbar for 10 min and the conversion was calculated by integration ofproduct peaks to a quantified internal standard (nitrobenzene).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Benzo[d]imidazol-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Roeder, Liesa; Nicholls, Alexander J.; Baxendale, Ian R.; Molecules; vol. 24; 10; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 934-32-7 as follows. Recommanded Product: 1H-Benzo[d]imidazol-2-amine

General procedure: A mixture of ethyl acetoacetate and/or acetylacetone (1 mmol) or malononitrile(1.1 mmol), 2-aminobenzimidazole (1 mmol), aldehyde (1 mmol) and [PVPH]ClO (30 mg, 6.84 mol %) was heated at 100 C in an oil bath for the appropriate time.After completion of the reaction [monitored by thin layer chromatography (TLC): nhexane:ethyl acetate (3:1)], the reaction mixture was cooled to room temperatureand EtOH (5 mL) was added to it and filtered to separate the catalyst. Afterevaporation of the solvent from the filtrate, the crude solid product wasrecrystallized from ethanol to obtain pure A or B products.The spectral [IR, proton ( 1H) NMR and 13C NMR] data of new compounds arepresented below.

According to the analysis of related databases, 934-32-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Abedini, Masoumeh; Shirini, Farhad; Mousapour, Maryam; Goli Jolodar, Omid; Research on Chemical Intermediates; vol. 42; 7; (2016); p. 6221 – 6229;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 934-32-7,Some common heterocyclic compound, 934-32-7, name is 1H-Benzo[d]imidazol-2-amine, molecular formula is C7H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a round-bottom flask, catalyst 1 {[HIMI]C(NO2)3}(1.0 mol%, 2.2 mg) was added to a mixture of the corresponding aromatic aldehyde (1.0 mmol), 2-aminobenzimidazole(1.0 mmol, 133 mg), and malononitrile (1.0 mmol,66 mg). The obtained mixture was stirred magnetically at50 C under solvent-free conditions for the appropriate time. After completion of the reaction, as identified by TLC(n-hexane/EtOAc: 5/3), EtOAc (10 mL) was added, and the mixture was stirred and refluxed for 10 min. Then, the resulting solution was washed with water (10 mL). Separation of the phases led to the crude product in the EtOAc phase while catalyst 1 was soluble in water. The organic phase was dried (MgSO4) and the solvent evaporated to afford the corresponding crude product which was purified via recrystallization from ethanol/water (10:1).

The synthetic route of 934-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yarie, Meysam; Zolfigol, Mohammad Ali; Baghery, Saeed; Khoshnood, Abbas; Alonso, Diego A.; Kalhor, Mehdi; Bayat, Yadollah; Asgari, Asiye; Journal of the Iranian Chemical Society; vol. 15; 10; (2018); p. 2259 – 2270;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 934-32-7, name is 1H-Benzo[d]imidazol-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1H-Benzo[d]imidazol-2-amine

General procedure: A mixture of 2-aminobenzimidazole 7 (1.33 g, 10.0 mmol), 10.0 mmol of the proper alkyl halide, 1.0 g of finely powdered KOH mixed with 2.0 g of anhydrous K2CO3 and acetone (50 mL) was heated at reflux for 3 h, with stirring. The solvent was removed in vacuo and the residue was partitioned between water (100 mL) and CH2Cl2 (100 mL), and the aqueous phase was further extracted twice with CH2Cl2. The combined extracts, dried over anhydrous Na2SO4, after removal of solvent afforded an oily or solid residue which was treated with a small amount of ethyl ether to give compounds 8a-e,l-o as whitish solids which were crystallized from the proper solvent. Only in the case of compound 8f, a preliminary purification by column chromatography [SiO2/ethyl acetate-acetone (1:1)] was necessary to obtain a crystalline compound.

According to the analysis of related databases, 934-32-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Di Braccio, Mario; Grossi, Giancarlo; Signorello, Maria Grazia; Leoncini, Giuliana; Cichero, Elena; Fossa, Paola; Alfei, Silvana; Damonte, Gianluca; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 564 – 578;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

934-32-7, name is 1H-Benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H7N3

General procedure: A mixture of 2-aminobenzimidazole or 3-amino-1,2,4-triazole (1.0 mmol), arylaldehyde (1.0 mmol), dimedone (1.0 mmol), and 15 mol % p-TsOH.H2O was stirred in 5 cm3 acetonitrile as solvent at 40-50 C for the appropriate time (Table 3). The progress of the reaction was monitored by TLC. After completion of the reaction, a thick precipitate was obtained. The solid product was filtered off and washed with acetonitrile and subsequently dried in air. The pure product was characterized by conventional spectroscopic methods.

The synthetic route of 934-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mousavi, Mir Rasul; Maghsoodlou, Malek Taher; Monatshefte fur Chemie; vol. 145; 12; (2014); p. 1967 – 1973;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 934-32-7, name is 1H-Benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 934-32-7, Product Details of 934-32-7

General procedure: A mixture of -Fe2O3starch-n-butyl SO3H (10 mg),aromatic aldehyde (1.0 mmol), dimedone (1.0 mmol),2-aminobenzimidazole (1.0 mmol) was heated in an oilbath (100 C) for the appropriate reaction time until thecompletion. The progress of the reaction was monitoredby TLC (n-hexane:ethyl acetate, 8:4). After completion ofthe reaction water (10 mL) was added and the catalyst wassegregated using an external magnet, washed with chloroform,dried out, and used directly without an appreciableloss of its activity for the next run. The product was purifiedby recrystallization from EtOH and dried in air.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Shamsi-Sani, Mahnaz; Shirini, Farhad; Mohammadi-Zeydi, Masoud; Journal of Nanoscience and Nanotechnology; vol. 19; 8; (2019); p. 4503 – 4511;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 934-32-7, These common heterocyclic compound, 934-32-7, name is 1H-Benzo[d]imidazol-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of the requested benzylic aldehyde (1 mmol),2-aminobenzimidazole or 3-amino-1,2,4-triazole (1 mmol),beta-diketone (1 mmol) and NS-C4(DABCO-SO3H)2·4Cl(20 mg, 10 mol %) was heated at 90 C under solvent-freeconditions. The progress of the reaction was monitoredby TLC (n-hexane: EtOAc, 70:30). After completion ofthe reaction, the reaction mixture was cooled to roomtemperature and 3 mL of water was added to it. Thecatalyst was dissolved in water and filtered for separation ofthe crude product. The separated product was washed twicewith water (2 × 5 mL), and the crude product was purifiedby recrystallization in ethanol.

The synthetic route of 934-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Goli-Jolodar, Omid; Shirini, Farhad; Journal of the Iranian Chemical Society; vol. 14; 11; (2017); p. 2275 – 2286;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem