Obydennov, Konstantin L.’s team published research in Journal of Agricultural and Food Chemistry in 2021 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.COA of Formula: C7H7N3

Obydennov, Konstantin L.; Kalinina, Tatiana A.; Galieva, Nadezhda A.; Beryozkina, Tetyana V.; Zhang, Yue; Fan, Zhijin; Glukhareva, Tatiana V.; Bakulev, Vasiliy A. published their research in Journal of Agricultural and Food Chemistry in 2021. The article was titled 《Synthesis, Fungicidal Activity and Molecular Docking of 2-Acylamino and 2-Thioacylamino Derivatives of 1H-benzo[d]imidazoles as Anti-Tubulin Agents》.COA of Formula: C7H7N3 The article contains the following contents:

This work dealt with the synthesis and evaluation of fungicidal activity of benzimidazole derivatives, which were structural analogs of com. anti-tubulin fungicides. A series of N-acyl and N-thioacyl derivatives of 2-amino-1H-benzo[d]imidazole I [R1 = H, Me, CF3, CO2Et; R2 = H; R3 = H, Me; R4 = Me, Ph, 2-thienyl, etc.; R1R2 = OCF2O; X = O, S] was prepared and their fungicidal activity against 13 strains of phytopathogenic fungi was studied. The most active compounds against the majority of the studied strains were compounds I [R1 = H, R2 = H, R3 = H, R4 = Ph, X = O; R1 = H, R2 = H, R3 = H, R4 = CF3, X = S; R1R2 = OCF2O, R3 = H, R4 = CF3, X = S] and the EC50 values of these compounds were in the range 2.5-20μg/mL. Compound I [R1 = H, R2 = H, R3 = H, R4 = Ph, X = O] showed the highest activity against the P. infestans strain, the growth of which was not suppressed by carbendazim. The formation of ligand-receptor complexes of various tautomeric forms of the studied benzimidazoles with homologous models of β-tubulins of B. cinerea, F. oxysporum, and P. infestans was modeled. Induced fit docking had been used for the simulation. The obtained data suggested the possibility of binding of benzimidazole fungicides to β-tubulin in the “”nocodazole cavity”” in the tautomeric form bearing a double exocyclic C=N bond. The importance of the formation of hydrogen bonds of benzimidazoles with the amino acid residue Val236 along with the Glu198 residue was also revealed in the present study.1H-Benzo[d]imidazol-2-amine(cas: 934-32-7COA of Formula: C7H7N3) was used in this study.

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.COA of Formula: C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dawood, Dina H.’s team published research in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2019 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Product Details of 934-32-7

The author of 《ZnO Nanoparticles Catalyst in the Synthesis of Bioactive Fused Pyrimidines as Anti-breast Cancer Agents Targeting VEGFR-2》 were Dawood, Dina H.; Abbas, Eman M. H.; Farghaly, Thoraya A.; Ali, Mamdouh M.; Ibrahim, Mohammed F.. And the article was published in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2019. Product Details of 934-32-7 The author mentioned the following in the article:

A new series of fused pyrimidines I (Ar = C6H5, 4-FC6H4, 4-ClC6H4 etc.), II, III using ZnO(NPs) have been synthesized and investigated for their antitumor efficiency against breast MCF7 cancer and their VEGFR- 2 inhibition properties. The proposed structures of all new fused pyrimidines are in agreement with their spectral data. It was apparent that the 2-phenylpyrazolo[1,5-a]pyrimidine derivatives II (Ar = C6H5) (IC50 = 9.12+/-177;1.16+/-181;g/mL), II (Ar = 2-pyridyl) (IC50 = 9.10+/-177;1.07+/-181;g/mL) and II (Ar = 2-furyl)(IC50 = 9.60+/-177;1.22+/-181;g/mL) exhibited equipotent antitumor activity as Tamoxifen (IC50 = 9.11+/-177;0.90+/-181;g/mL). Also, the inhibitory activity of the novel fused pyrimidine derivatives II (Ar = C6H5, 2-pyridyl, 2-furyl) on VEGFR-2 as well as Tamoxifen was determined using breast cancer cell line MCF-7. The data was obvious that 2-phenylpyrazolo[1,5-a]pyrimidine derivatives exhibited noticeable VEGFR-2 inhibitory effect with %inhibition ranging from 80-84% vs. Tamoxifen 93.5%.1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Product Details of 934-32-7) was used in this study.

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Product Details of 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pareek, Shubhra’s team published research in Chemical Engineering Journal (Amsterdam, Netherlands) in 2019 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Safety of 1H-Benzo[d]imidazol-2-amine

In 2019,Chemical Engineering Journal (Amsterdam, Netherlands) included an article by Pareek, Shubhra; Jain, Deepti; Hussain, Shamima; Biswas, Amrita; Shrivastava, Rahul; Parida, Saroj K.; Kisan, Hemanta K.; Lgaz, Hassane; Chung, Ill-Min; Behera, Debasis. Safety of 1H-Benzo[d]imidazol-2-amine. The article was titled 《A new insight into corrosion inhibition mechanism of copper in aerated 3.5 weight% NaCl solution by eco-friendly Imidazopyrimidine Dye: experimental and theoretical approach》. The information in the text is summarized as follows:

A large number of mechanism were anticipated for Cu since 1988 in NaCl medium. The detail electrochem. behavior leading to the anodic dissolution of Cu, however, still remains uncertain. Herein, an Imidazopyrimidine Dye, named, 4-amino-3-(phenyldiazenyl)benzo[4,5]imidazo[1,2-a]pyrimidin-2(1H)-one, (APIP) was used as a Cu corrosion inhibitor in 3.5% (by weight) NaCl solution The present study provides a brief mechanistic overview of the electrochem. mechanism of Cu in aerated NaCl solution, simulating a static marine environment, with and without addition of APIP inhibitor. Potentiodynamic polarization (PDP) results confirmed that the APIP can suppress Cu corrosion effectively at low concentration in 3.5% NaCl solution with an inhibition efficiency of 92.79% due to adsorption, along with the prediction of electrochem. mechanism. Electrochem. impedance spectroscopy (EIS) measurements showed that the corrosion inhibition of Cu proceeds via both diffusion and kinetic controlled processes. Adsorption of APIP on Cu surface is well fit with the Langmuir isotherm model and mode of adsorption is proposed. Antimicrobial activity was also studied and the result obtained showed ”eco-friendly” nature of APIP. Field Emission Scanning Electron Microscope (FE-SEM), Energy dispersion x-ray (EDX) and Attenuated Total Reflectance-FTIR Spectroscopy (ATR-FTIR) observations of the Cu surfaces confirmed the existence of adsorption of APIP thus can be potentially used in industries in which seawater is implied are numerous such as cooling H2O systems, desalination plants, power plants, and oil production units. Results obtained from theor. calculations including quantum chem. d. functional theory (DFT) method and mol. dynamics (MD) simulations confirms the exptl. findings and provide further insight into the mode of adsorption on the Cu surface. In the experiment, the researchers used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Safety of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Safety of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Basyouni, Wahid M.’s team published research in Organic Preparations and Procedures International in 2020 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Related Products of 934-32-7

《Silica Sulfuric Acid/Ethylene Glycol: An Efficient Eco-Friendly Catalyst for One-Pot Synthesis of New Benzo[4,5]imidazo[1,2-a]pyrimidines》 was published in Organic Preparations and Procedures International in 2020. These research results belong to Basyouni, Wahid M.; Abdelazeem, Nagwa M.; Abbas, Samir Y.; El-Bayouki, Khairy A. M.; El-kady, Mohamed Y.. Related Products of 934-32-7 The article mentions the following:

A novel catalyst (SSA/ethylene glycol) for the efficient synthesis of new benzo[4,5]imidazo[1,2-a]pyrimidine derivatives I (R = H, acetyl; R1 = Me, Ph; R2 = Ph, 3-bromophenyl, thiophen-2-yl, etc.) in high yield and good purity was demonstrated. The reaction was achieved via three-component condensation reactions. SSA/ethylene glycol offers several advantages for the preparation of novel heterocycles I. Among these are simplicity, mild reaction conditions, and little environmental impact. The investigations will spur the exploration of this useful reagent combination in the synthesis of new heterocyclic systems. The experimental part of the paper was very detailed, including the reaction process of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Related Products of 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Related Products of 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pinheiro da Costa, Elizangela’s team published research in Environmental Science and Pollution Research in 2019 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Synthetic Route of C7H7N3

In 2019,Environmental Science and Pollution Research included an article by Pinheiro da Costa, Elizangela; Bottrel, Sue Ellen C.; Starling, Maria Clara V. M.; Leao, Monica M. D.; Amorim, Camila Costa. Synthetic Route of C7H7N3. The article was titled 《Degradation of carbendazim in water via photo-Fenton in Raceway Pond Reactor: assessment of acute toxicity and transformation products》. The information in the text is summarized as follows:

This study aimed at investigating the degradation of fungicide carbendazim (CBZ) via photo-Fenton reactions in artificially and solar irradiated photoreactors at laboratory scale and in a semi-pilot scale Raceway Pond Reactor (RPR), resp. Acute toxicity was monitored by assessing the sensibility of bioluminescent bacteria (Aliivibrio fischeri) to samples taken during reactions. In addition, byproducts formed during solar photo-Fenton were identified by liquid chromatog. coupled to mass spectrometry (UFLC-MS). For tests performed in lab-scale, two artificial irradiation sources were compared (UVλ>254nm and UV-Visλ>320nm). A complete design of experiments was performed in the semi-pilot scale RPR in order to optimize reaction conditions (Fe2+ and H2O2 concentrations, and water depth). Efficient degradation of carbendazim (> 96%) and toxicity removal were achieved via artificially irradiated photo-Fenton under both irradiation sources. Control experiments (UV photolysis and UV-Vis peroxidation) were also efficient but led to increased acute toxicity. In addition, H2O2/UVλ>254nm required longer reaction time (60 min) when compared to the photo-Fenton process (less than 1 min). While Fenton’s reagent achieved high CBZ and acute toxicity removal, its efficiency demands higher concentration of reagents in comparison to irradiated processes. Solar photo-Fenton removed carbendazim within 15 min of reaction (96%, 0.75 kJ L-1), and monocarbomethoxyguanidine, benzimidazole isocyanate, and 2-aminobenzimidazole were identified as transformation products. Results suggest that both solar photo-Fenton and artificially irradiated systems are promising routes for carbendazim degradation1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Synthetic Route of C7H7N3) was used in this study.

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Synthetic Route of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Brahmeshwari, G.’s team published research in International Journal of Pharmacy and Biological Sciences in 2019 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.HPLC of Formula: 934-32-7

In 2019,International Journal of Pharmacy and Biological Sciences included an article by Brahmeshwari, G.; Dhanaja, K.; Gullapelli, Kumaraswamy; Muralikrishna, T.. HPLC of Formula: 934-32-7. The article was titled 《Synthesis and antioxidant activity of new thioxo triazinane 2-one derivatives》. The information in the text is summarized as follows:

4-Thioxo,1,3,5-triazinane-2-ones were synthesized by the fusion of aryl isocyanides with 2-aminobenzimidazole. All the compounds were screened for their antioxidant activity by the determination of DPPH, superoxide, and nitric oxide scavenging. Some of the title compounds were proved promising activity against the test organisms, employed. The structures of newly synthesized compounds were established on the basis of spectroscopic anal. In the part of experimental materials, we found many familiar compounds, such as 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7HPLC of Formula: 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.HPLC of Formula: 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zadeh, Elnaz Ebrahim’s team published research in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2021 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Application of 934-32-7

Zadeh, Elnaz Ebrahim; Vahabpour, Rouhollah; Beirami, Amirreza Dowlati; Hajimahdi, Zahra; Zarghi, Afshin published an article in 2021. The article was titled 《Novel 4-Oxo-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors: Synthesis, Docking Studies, Molecular Dynamics Simulation and Biological Activities》, and you may find the article in Medicinal Chemistry (Sharjah, United Arab Emirates).Application of 934-32-7 The information in the text is summarized as follows:

HIV-1 integrase (IN) has been considered as an important target for the development of novel anti-HIV-1 drugs. The aim of this study was to design novel groups of HIV IN inhibitors. In this study, we presented a novel series of 4-oxo-4,10-dihydrobenzo[4,5]imidazo[1,2- a]pyrimidine-3-carboxylic acid derivatives by structural modification of N-arylindole β-diketoacids as a well-known group of IN inhibitors. Based on in-vitro anti-HIV-1 activity in a cell-based assay, compounds 5, 6a and 6k displayed moderate to good inhibitory activity with EC50 values of 4.14, 1.68 and 0.8 μM, resp. However, integrase inhibition assay showed that most of the analogs did not have significant effects against integrase enzyme except compound 5 with an IC50 value of 45 μM. Our results indicated that compound 6k was the best one among synthesized compounds with an EC50 of 0.8 μM and SI of 175. Docking and mol. dynamics simulation studies were also performed to provide some insights into the probable mechanism of tested compounds These findings suggest that 4-oxo-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3- carboxylic acid derivatives may consider as promising lead compounds for the development of new anti-HIV-1 drugs. In addition to this study using 1H-Benzo[d]imidazol-2-amine, there are many other studies that have used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Application of 934-32-7) was used in this study.

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Application of 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sreeja, S.’s team published research in International Journal of Pharmacy and Pharmaceutical Sciences in 2021 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Application of 934-32-7

Sreeja, S.; Anton, Smith A.; Madan, S.; Sunilkumar, D.; Vani, V. published their research in International Journal of Pharmacy and Pharmaceutical Sciences in 2021. The article was titled 《Computational molecular modelling of 2-aminobenzimidazole derivatives: strong successor of hypoglycaemic agent》.Application of 934-32-7 The article contains the following contents:

The present study was aimed to design different analogs of 2-aminobenzimidazole and find the binding ability by Insilico method. Various softwares like Chemsketch, Molinspiration, PASS, and Discovery studio were used to design the proposed derivatives Evaluation of binding activity against different receptors was detected and checked their physicochem. properties for binding. In this study, we designed different analogs of 2-aminobenzimidazole into a ligand having a binding affinity with alpha-glucosidase, Dipeptidyl-peptidase 4 (DPP4), Peroximase proliferator-activated receptor gamma (PPARγ), and Insulin-like growth factor 1 (IGF-1) receptor. The designed ten derivatives showed a significant binding capacity to the concerned receptors. These results pointed that the designed proposed derivatives promising hypoglycemic activity. In the part of experimental materials, we found many familiar compounds, such as 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Application of 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Application of 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xing, Ai-Ping’s team published research in Zeitschrift fuer Kristallographie – New Crystal Structures in 2019 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Computed Properties of C7H7N3

In 2019,Zeitschrift fuer Kristallographie – New Crystal Structures included an article by Xing, Ai-Ping; Zeng, Dai; Zhang, Shu-Ling; Wei, Jun-Jun; Guo, Da-Feng. Computed Properties of C7H7N3. The article was titled 《Crystal structure of 2-((1H-benzo[d]imidazol-2-ylimino)methyl)-4,6-di-tert-butylphenol, C22H27N3O》. The information in the text is summarized as follows:

C22H27N3O, monoclinic, P21/c (number 14), a = 18.4984(4) Å, b = 11.4221(3) Å, c = 9.79600(19) Å, β = 90.9652(19)°, V = 2069.51(8) Å3, Z = 4, Rgt(F) = 0.0605, wRref(F2) = 0.1773, T = 293(2) K. In a typical experiment 2-aminobenzimidazole (1.3315 g, 10 mmol) and 3,5-bis(1,1-dimethylethyl)-2-hydroxy-benzaldehyde (2.3433 g, 10 mmol) were mixed in 25 mL ethanol and refluxed for 3 h. When the solution was cooled to room temperature, a light yellow solid was obtained. Crystallization from methanol at room temperature gave the title compound as colorless crystals of good diffraction quality. The experimental process involved the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Computed Properties of C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Computed Properties of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Han, Jia Hong’s team published research in Journal of Photochemistry and Photobiology, A: Chemistry in 2021 | CAS: 934-32-7

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.COA of Formula: C7H7N3

《An AIE-active probe for selective fluorometric-colorimetric detection of HSO3- in aqueous solution and real samples》 was written by Han, Jia Hong; Gao, Wen Ying; Feng, Li Heng; Wang, Yu; Shuang, Shao Min. COA of Formula: C7H7N3 And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2021. The article conveys some information:

We report herein a new biphenylcarbonitrile derivative, 4′-hydroxy-3′ -((2-imidazolylimino) methyl)-4-biphenyl carbonitrile (HIBC), which interestingly exhibits an aggregation-induced emission property. HIBC was employed for selective dual mode (fluorimetric and colorimetric) assay of HSO3- ions in nearly 100% aqueous medium at pH 7.4. The nucleophilic addition of HSO3- on the imino group in HIBC breaks its π-electron conjugation and results in a noticeable absorption and fluorescence spectral changes accompanied by a visible color change. Moreover, the formation of anionic addition product weakened the aggregation effect and meanwhile inhibited ESIPT process in HIBC, causing quenching of keto fluorescence of the probe. The probe shows good selectivity for HSO3- ions over all other competitive anions, which renders it a promising candidate for ratiometric fluorescent assay of HSO3- in aqueous systems. The limit of detection is 1.83 x 10-7 mol/L. For the practical applicability, handy paper strips were fabricated from HIBC for convenient recognition of HSO3-. Addnl., HIBC was applied for the living HeLa cells bio-imaging. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7COA of Formula: C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.COA of Formula: C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem