Category: 934-32-7

In 2019,Journal of Molecular Structure included an article by Narendra babu, Kayathi; Nagarjuna, Ummadi; Reddy, Guda Dinneswara; Padmaja, Adivireddy; Padmavathi, Venkatapuram. Category: imidazoles-derivatives. The article was titled 《Synthesis and antimicrobial activity of benzazolyl azolyl urea derivatives》. The information in the text is summarized as follows:

A new class of benzazolyl azolyl urea derivatives were prepared by the reaction of Me benzazoyl carbamates with azolyl amines in the presence of mild base potassium tert-butoxide. The synthesized titled compounds were evaluated for antibacterial and antifungal actvities and the presence of electron withdrawing substituents on the aromatic ring enhanced the activity. Nitro substituted benzothiazolyl thiazolyl urea, benzothiazolyl imidazolyl urea and benzimidazolyl thiazolyl urea exhibited potential antibacterial activity against Bacillus subtilis. The compound benzothiazolyl imidazolyl urea and nitro substituted benzimidazolyl imidazolyl urea showed potential antifungal activity against Aspergillus niger. The results came from multiple reactions, including the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Category: imidazoles-derivatives)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Category: imidazoles-derivativesIn 2019 ,《Green, effective and chromatography free synthesis of benzoimidazo[1,2-a]pyrimidine and tetrahydrobenzo [4,5]imidazo [1,2-d]quinazolin-1(2H)-one and their pyrazolyl moiety using Fe3O4@SiO2@L-proline reusable catalyst in aqueous media》 appeared in Journal of Organometallic Chemistry. The author of the article were Fekri, Leila Zare; Nikpassand, Mohammad; Khakshoor, Samira Nazari. The article conveys some information:

L-proline-functionalized silica-coated Fe3O4 nanoparticle was synthesized and characterized using Fourier Transform IR spectroscopy, X-ray diffraction, field emission SEM, transmission electron microscopy, energy dispersive X-ray spectroscopy, thermogravimetric anal., Zeta potential and a vibrating sample magnetometer. The Fe3O4@SiO2@L-proline nanoparticles in aqueous media were used as a green avenue for the mild and efficient multicomponent synthesis of new derivatives of benzoimidazo[1,2-a]pyrimidines and tetrahydrobenzo[4,5]imidazo-[1,2-d]quinazolin-1(2H)-ones in excellent yields. Furthermore, the recovery and reuse of the catalyst was demonstrated 10 times without a detectable loss in activity. Eco-friendliness, high purity of the desired products, short reaction time and easy workup was mentioned as the other advantages of this method. The results came from multiple reactions, including the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Category: imidazoles-derivatives)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of C7H7N3In 2020 ,《Copper-Catalyzed Synthesis of Trinuclear N-Fused Hybrid Scaffolds by Double C(sp2)-N Bond Formation between 2-(2-Bromoaryl)indoles and 2-Aminoazoles》 appeared in European Journal of Organic Chemistry. The author of the article were Diep, Thi Duyen; Pham, Duy Quang Dao; Ho, Son Long; Cho, Chan Sik. The article conveys some information:

2-(2-Bromoaryl)indoles react with 2-aminoazoles by microwave irradiation in DMF in the presence of a catalytic amount of CuI and a base to produce trinuclear N-fused hybrid scaffolds, benzo[4,5]imidazo[1,2-a]indolo[1,2-c]quinazolines and imidazo[1,2-a]indolo[1,2-c]quinazolines in moderate to good yields [e.g., 2-(2-bromophenyl)indole + 2-aminobenzimidazole → I (74%) in presence of CuI and K3PO4 in DMF]. The reaction seems to proceed via copper-catalyzed C(sp2)-N coupling and subsequent intramol. cyclocondensation accompanied by ammonia evolution. Complete regioselective C-N cyclization is observed with the reaction of 2-(2-bromophenyl)indole with 2-aminoazoles. In the part of experimental materials, we found many familiar compounds, such as 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Electric Literature of C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Electric Literature of C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C7H7N3In 2020 ,《Surface analysis and interface properties of 2-aminobenzimidazole corrosion inhibitor for brass in chloride solution》 was published in Analytical and Bioanalytical Chemistry. The article was written by Finsgar, Matjaz. The article contains the following contents:

This work presents a corrosion study of 2-aminobenzimidazole (ABI) as a corrosion inhibitor for brass in chloride solution Electrochem., field emission SEM, at. force microscopy, and contact angle measurements showed that ABI mitigates brass corrosion after short-, medium-, and long-term immersion periods. Next, a detailed surface anal. of the ABI adsorbed on the brass surface was performed using attenuated total reflectance Fourier transform IR spectroscopy, XPS, and time-of-flight secondary ion mass spectrometry (ToF-SIMS) techniques. XPS imaging was performed in association with principal component anal. to determine the different phases on the surface. In order to describe the in-depth composition of the ABI surface, an angle-resolved XPS anal. was performed. This anal. was further supported by gas cluster ion beam sputtering to gradually remove the ABI surface layer, and XPS anal. was performed after each sputtering cycle. Finally, TOF-SIMS analyses showed the formation of Cu/Cu2-ABI and Zn-ABI compounds, the 2D distribution of ABI-related compounds, and their thermal stability on the brass surface. The experimental part of the paper was very detailed, including the reaction process of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7COA of Formula: C7H7N3)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.COA of Formula: C7H7N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kollar, Levente; Gobec, Martina; Szilagyi, Bence; Proj, Matic; Knez, Damijan; Abranyi-Balogh, Peter; Petri, Laszlo; Imre, Timea; Bajusz, David; Ferenczy, Gyorgy G.; Gobec, Stanislav; Keseru, Gyorgy M.; Sosic, Izidor published an article in 2021. The article was titled 《Discovery of selective fragment-sized immunoproteasome inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.Reference of 1H-Benzo[d]imidazol-2-amine The information in the text is summarized as follows:

Proteasomes contribute to maintaining protein homeostasis and their inhibition is beneficial in certain types of cancer and in autoimmune diseases. However, the inhibition of the proteasomes in healthy cells leads to unwanted side-effects and significant effort has been made to identify inhibitors specific for the immunoproteasome, especially to treat diseases which manifest increased levels and activity of this proteasome isoform. Here, we report our efforts to discover fragment-sized inhibitors of the human immunoproteasome. The screening of an inhouse library of structurally diverse fragments resulted in the identification of benzo[d]oxazole-2(3H)-thiones, benzo[d]thiazole-2(3H)-thiones, benzo[d]imidazole-2(3H)-thiones, and 1-methylbenzo[d]imidazole-2(3H)-thiones (with a general term benzoXazole-2(3H)-thiones) as inhibitors of the chymotrypsin-like (β5i) subunit of the immunoproteasome. A subsequent structure-activity relationship study provided us with an insight regarding growing vectors. Binding to the β5i subunit was shown and selectivity against the β5 subunit of the constitutive proteasome was determined Thorough characterization of these compounds suggested that they inhibit the immunoproteasome by forming a disulfide bond with the Cys48 available specifically in the β5i active site. To obtain fragments with biol. more tractable covalent interactions, we performed a warhead scan, which yielded benzoXazole-2-carbonitriles as promising starting points for the development of selective immunoproteasome inhibitors with non-peptidic scaffolds. The results came from multiple reactions, including the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Reference of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Reference of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Devine, Shane M.; Challis, Matthew P.; Kigotho, Jomo K.; Siddiqui, Ghizal; De Paoli, Amanda; MacRaild, Christopher A.; Avery, Vicky M.; Creek, Darren J.; Norton, Raymond S.; Scammells, Peter J. published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Discovery and development of 2-aminobenzimidazoles as potent antimalarials》.SDS of cas: 934-32-7 The article contains the following contents:

The design, synthesis and antimalarial activity of a series of 2-aminobenzimidazoles I [R = H, NH2, NHEt, NHBn, etc.; Ar = 2-HOC6H4, 2-NH2C6H4, benzofuran-7-yl, etc.], featuring a phenol moiety that was crucial to the pharmacophore. Two potent mols. exhibited IC50 values against P. falciparum 3D7 strain of 42 ± 4 I [R = NH2; Ar = 5-Me-2-HOC6H3] and 43 ± 2 nM [R = NH2; Ar = 5-MeO-2-HOC6H3] and high potency against strains resistant to chloroquine (Dd2), artemisinin (Cam3.IIC580Y) and PfATP4 inhibitors (SJ557733), while demonstrating no cytotoxicity against human cells (HEK293, IC50 > 50μM). The most potent mol., possessing a 4,5-di-Me substituted phenol I [R = NH2; Ar = 4,5-(MeO)2-2-HOC6H2] displayed an IC50 value of 6.4 ± 0.5 nM against P. falciparum 3D7, representing a 12-fold increase in activity from the parent mol. The 2-aminobenzimidazoles containing a N1-substituted phenol represented a new class of mols. that had high potency in vitro against P. falciparum malaria and low cytotoxicity. They possessed attractive pharmaceutical properties, including low mol. weight, high ligand efficiency, high solubility, synthetic tractability and low in vitro clearance in human liver microsomes. After reading the article, we found that the author used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7SDS of cas: 934-32-7)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.SDS of cas: 934-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Analytical and Bioanalytical Chemistry Research included an article by Rajamohana, R.; Nayakib, S. Kothai; Swaminathanc, M.; Sivakumard, K.. Safety of 1H-Benzo[d]imidazol-2-amine. The article was titled 《pH independent complexation of 2-aminobenzimidazole with β-cyclodextrin》. The information in the text is summarized as follows:

The spectral characteristics of 2-aminobenzimidazole (2ABZ) in aqueous and ss-cyclodextrin media has been investigated using absorption, steady state and time resolved fluorescence techniques. The stoichiometric ratio of the inclusion complex of neutral and monocationic forms of 2ABZ in β-CDx medium is found to be 1:1. There is no significant differences between ground and the excited state pKa values of 2ABZ under both the media and thus the amino group of 2ABZ mol. is not much affected by the complexation process i.e., it lies outside the β-CDx cavity. Considering the shape and dimensions of β-CDx, it is clear that the 2ABZ mol. cannot be completely included in the β-CDx cavity. Because, the overall height of 2ABZ is 10.6 Å, but the overall height of β-CDx is only 7.8 Å. Hence, it is possible to locate half of the 2ABZ mol. only permitted inside the β-CDx cavity as interpreted using exptl. data. In the experiment, the researchers used 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Safety of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Safety of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Nanostructured γ-Fe2O3@Starch-n-Butyl SO3H as new recyclable magnetic catalyst for promoting multi-component reactions》 were Shamsi-Sani, Mahnaz; Shirini, Farhad; Mohammadi-Zeydi, Masoud. And the article was published in Journal of Nanoscience and Nanotechnology in 2019. Application In Synthesis of 1H-Benzo[d]imidazol-2-amine The author mentioned the following in the article:

Butane-1-soltunic acid modified starch-coated γ-Fe2O3 magnetic nanoparticles [γ-Fe2O3@starch- Bu SO3H] was easily prepared through a ring opening reaction of 1,4-butane sultone with nano- magnetic γ-Fe2O3@starch. After structural studies, using FT-IR, SEM, XRD, TGA, TEM, EDX, VSM and also pH anal. the efficiency of this reagent in the preparation of tetrahydrobenzinnidazo[2,1-b] quinazolin-1(2H)-ones and 2H-indazolo[2,1-b]phthalazine-triones was studied. Operational simple- ness, high yields, short reaction times, wide applicability and simple recyclability of the catalyst employing an external magnet are the most important advantages of this methodol. The experimental part of the paper was very detailed, including the reaction process of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Application In Synthesis of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Application In Synthesis of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling》 was written by Ferreira, Rafael Augusto Alves; Junior, Celso de Oliveira Rezende; Martinez, Pablo David Grigol; Koovits, Paul John; Soares, Bruna Miranda; Ferreira, Leonardo L. G.; Michelan-Duarte, Simone; Chelucci, Rafael Consolin; Andricopulo, Adriano D.; Galuppo, Mariana K.; Uliana, Silvia R. B.; Matheeussen, An; Caljon, Guy; Maes, Louis; Campbell, Simon; Kratz, Jadel M.; Mowbray, Charles E.; Dias, Luiz Carlos. Recommanded Product: 1H-Benzo[d]imidazol-2-amine And the article was included in PLoS Neglected Tropical Diseases in 2021. The article conveys some information:

Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this life-threatening infection have several drawbacks such as toxicity and long treatment regimens. A library of 1.8 million compounds, from which the hits reported here are publicly available, was screened against Leishmania infantum as part of an optimization program; a compound was found with a 2-aminobenzimidazole functionality presenting moderate potency, low metabolic stability and high lipophilicity. Several rounds of synthesis were performed to incorporate chem. groups capable of reducing lipophilicity and clearance, leading to the identification of compounds that are active against different parasite strains and have improved in vitro properties. As a result of this optimization program, a group of compounds was further tested in anticipation of in vivo evaluation. In vivo tests were carried out with compounds 29 (L. infantum IC50: 4.1 μM) and 39 (L. infantum IC50: 0.5 μM) in an acute L. infantum VL mouse model, which showed problems of poor exposure and lack of efficacy, despite the good in vitro potency. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Recommanded Product: 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Recommanded Product: 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quality Control of 1H-Benzo[d]imidazol-2-amineIn 2020 ,《Synthesis, characterization and antibacterial studies of Schiff base with 2-amino benzimidazole and 5-methyl-thiophene-2-carboxaldehyde》 was published in Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences. The article was written by Kanthamma, D. Lakshmi; Kumar, N. Sathish; Imran, K.; Seshaiah, K.. The article contains the following contents:

A new Schiff base has been synthesized by condensation of 2-Amino benzimidazole and 5-methyl-thiophene-2-carboxaldehyde. The compound was characterized by FT-IR, 1H NMR Spectroscopy, 13C NMR Spectroscopyto confirm the structure of Schiff base. The Cu(II) and Zn(II) complexes were prepared using the Schiff base. The Schiff base and its metal complexes have been studied for antibacterial activity against the strains such as Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa, Escherichia coli.The metal complexes of Schiff base exhibited more antibacterial activity as compared to Schiff base ligand. The experimental process involved the reaction of 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7Quality Control of 1H-Benzo[d]imidazol-2-amine)

1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.Quality Control of 1H-Benzo[d]imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem