Reference of 931-36-2,Some common heterocyclic compound, 931-36-2, name is 2-Ethyl-5-methyl-1H-imidazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: alpha,beta-unsaturated compound (4.8 mmol) was added dropwise to a well stirred mixture of N-heterocycle substrate (4.0 mmol) in [n-butyl urotropinium]OH (0.108 g, 0.25 mmol) and the reaction mixture was stirred for required time until completion of reaction (TLC). The product was then directly distilled out from the reaction mixture to provide pure Michael adducts (3a-3f and 4a-4f) in high yields.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Ethyl-5-methyl-1H-imidazole, its application will become more common.
Reference:
Article; Kumar, Sitanshu; Kaur, Amanpreet; Singh, Vasundhara; Synthetic Communications; vol. 49; 2; (2019); p. 193 – 201;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem