Category: 930-62-1

Electric Literature of 930-62-1,Some common heterocyclic compound, 930-62-1, name is 2,4-Dimethylimidazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound TX63822: Compound 11 (0.2 mmol) and 2,4-Dimethyl-lH- imidazole (19.2 mg, 0.2 mmol) were taken up in toluene (1 mL), and the mixture was stirred at room temperature for 65 h, no reaction happened. Additional 2,4-Dimethyl- lH-imidazole (76.8 mg, 0.8 mmol) and toluene (2 mL) was added, and the mixture was stirred at room temperature for 3h. The reaction mixture was quenched with H20 (10 mL) and extracted with CH2C12 (2×5 mL). The combined organic phase was filtered through a Na2S04 plug, then directly loaded on a silica gel column and purified by column chromatography (silica gel, twice, 0-65 % EtOAc in Hexanes then 0-60% EtOAc in Hexanes) to give the compound TX63822 as a white solid (22.2 mg, 22%). 1H NMR (500 MHz, CDC13) delta 8.02 (s, 1H), 7.22 (s, 1H), 6.03 (s, 1H), 3.25- 3.30 (m, 1H), 3.06 (d, 1H, J = 4.5 Hz), 2.56 (s, 3H), 2.42-2.51 (m, 1H), 2.19 (s, 3H), 1.95-2.16 (m, 3H), 1.83-1.93 (m, 2H), 1.58-1.77 (m, 4H), 1.15-1.45 (m, 6H), 1.44 (s, 3H), 1.30 (s, 3H), 1.24 (d, 3H, J = 6.5 Hz), 1.06 (s, 3H), 1.04 (s, 3H), 0.95 (s, 3H); m/z 556 (M+l).

The synthetic route of 930-62-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REATA PHARMACEUTICALS, INC.; ANDERSON, Eric; JIANG, Xin; VISNICK, Melean; BENDER, Christoper, F.; LIU, Xiaofeng; WO2012/125488; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 930-62-1, name is 2,4-Dimethylimidazole, A new synthetic method of this compound is introduced below., SDS of cas: 930-62-1

Preparation 14 Ethyl N-trifluoroacetyl-N-(2-nitro-5-[2,4-dimethylimidazol-1-yl]benzyl)glycinate STR36 A mixture of 2,4-dimethylimidazole (6.25 g), ethyl N-trifluoroacetyl-N-(5-fluoro-2-nitrobenzyl)glycinate (22.0 g) and sodium carbonate (6.62 g) was stirred and heated at 130 for 2 hours. Volatile material was removed from the cooled mixture in vacuo and the residue was partitioned between ethyl acetate (200 cm3) and water (100 cm3). The organic phase was washed with water (2*25 cm3), dried (MgSO4), and evaporated in vacuo to give an oil which was chromatographed on silica (Merck “MK 60.9385” [Trade Mark]) eluding with ethyl acetate:methanol, 1:19. Combination and evaporation of the appropriate fractions gave an oil which crystallized on trituration with ether to afford the title compound, m.p. 172.5-176 (3.1 g). Analysis %: Found: C,50.7; H,4.8; N,12.7; Calculated for C18 H19 F3 N4 O5: C,50.5; H,4.5; N,13.1.

The synthetic route of 930-62-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc.; US4783467; (1988); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 930-62-1, name is 2,4-Dimethylimidazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2,4-Dimethylimidazole

A solution of methyl mesylate (25.4 mL, 300 mmol) in acetone (50 mL) was added dropwise to a stirred mixture of 2,4-dimethylimidazole (25.00 g, 260 mmol), potassium carbonate (55.20 g, 400 mmol) and acetone (500 mL). Stirring under argon was then continued at room temperature for 16 hours. The resulting solid was filtered off, and the solvent was removed under reduced pressure. The residue was triturated with THF (200 mL) to give crystalline product (59-3) (14.47 g, 25% yield).The filtrate was treated with activated charcoal, filtered through a layer of Celite, and the solvent was removed under reduced pressure. Upon storage of the residue at room temperature, some crystalswere formed, and these crystals were separated, washed with THF and dried in a vacuum oven to give1,2,4-trimethylimidazole (59-1) (4.01 g, 14% yield). Concentration of the filtrate gave a mixture of isomeric imidazoles (59-1) and (59-2) (12.19 g, 43% yield).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 930-62-1.

Reference:
Patent; NITTO DENKO CORPORATION; STANISLAW, Rachwal; HU, Yufen; ZHANG, Hongxi; (0 pag.)WO2018/161025; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 930-62-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 930-62-1, name is 2,4-Dimethylimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The ILs as illustrated in Scheme 1, including [Ch][Im], [Ch]-[2-MIm], [Ch][4-MIm], [Ch][2,4-DMIm], [Ch][PhO] and[Ch][2-OP], were synthesized by neutralization of cholinehydroxide ([Ch][OH]) with the corresponding proton donors(i.e., imidazole, 2-methyl imidazole, 4-methyl imidazole,2,4-dimethyl imidazole, phenol, and 2-methyl phenol), respectively.In a typical experiment to synthesize [Ch][Im], anethanol solution of [Ch][OH] was mixed with equimolarimidazole, and was then stirred at room temperature for 24 h.Subsequently, ethanol and water were distilled off at 70 C under reduced pressure. The obtained [Ch][Im] was dried inhigh vacuum for 24 h at 70 C to remove possible trace ofwater. The water content of these ILs was determined by using a Karl Fisher titration and found to be less than0.1 wt%. The as-synthesized ILs were characterized byNMR spectroscopy to verify their chemical structures.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dimethylimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Ruipeng; Zhao, Yanfei; Li, Zhiyong; Wu, Yunyan; Wang, Jianji; Liu, Zhimin; Science China Chemistry; vol. 62; 2; (2019); p. 256 – 261;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 930-62-1, name is 2,4-Dimethylimidazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C5H8N2

Copper oxide (0.045 g, 0.316 mmol), 4,7-bis(methyloxy)-1 ,10-phenanthroline (0.228 g, 0.948 mmol), polyethylene glycol (1.248 g, 11.76 mmol), cesium carbonate (2.88 g, 8.84 mmol), 2,4-dimethyl-1 H-imidazole (0.729 g, 7.58 mmol) and 1 ,1-dimethylethyl3-chloro-5-iodobenzoate (D53, 2.139 g, 6.32 mmol) were transferred into a dried round-bottomed flask vial and capped with a rubber septum. The flask was then evacuated and backfilled with argon – this process was repeated several times. Butyronitrile (3.12 ml.) was then added and the mixture was stirred at 80 0C overnight during which time the reaction had evaporated to dryness. Further butyronitrile (3.12 ml.) was added and the mixture stirred at 80 0C over the weekend.The mixture was diluted with dichloromethane and then filtered through celite. The filtrate was concentrated in vacuo and the resulting crude material (2.8 g) was purified by flash chromatography with a gradient of 0 – 100% ethyl acetate in hexane to afford the title compound as a white solid.LC/MS (ES+ve): [M+H]+ at m/z 307, 309 (C16H19CIN2O2 requires [M+H]+ at m/z 307, 309)

According to the analysis of related databases, 930-62-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/819; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 930-62-1, The chemical industry reduces the impact on the environment during synthesis 930-62-1, name is 2,4-Dimethylimidazole, I believe this compound will play a more active role in future production and life.

Compound 5.5. 5-Iodo-2,4-dimethyl-lH-imidazole. NIS (14.0g, 62.4mmol) was added portion-wise to a solution of 2,4-dimethyl- lH-imidazole (5.00 g, 52.0 mmol) in acetonitrile (100 mL). The mixture was heated at 80 C for 16 hours, then cooled to room temperature. The solvent was removed under reduced pressure and the residue was partitioned between EtOAc (300 mL) and water (80 mL). The organic layer was washed with saturated sodium thiosulfate (50 mL), brine (50 mL), dried (MgS04) and concentrated under reduced pressure. The residue was purified with by silica gel column chromatography (hexanes:EtOAc 1 : 1 to 10% MeOH in EtOAc) to yield the title compound as a light yellow solid (8.56 g, 74%). m/z (ES+) 223(M+H)+. NMR (400 MHz, CDC13) delta 9.69 (br s, 1H), 2.38 (s, 3H), 2.19 (s, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dimethylimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; 3-V BIOSCIENCES, INC.; HEUER, Timothy Sean; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.; WO2015/95767; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 930-62-1, name is 2,4-Dimethylimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H8N2

2, 4-dimethylimidazole (1.58 g, 16.45 mmol) was dissolved in N, N-dimethylamine (60 mE). In an ice bath, to the solution was added sodium hydride (60% in mineral oil) (1.05 g, 26.3 mmol) slowly. The reaction mixture was reacted for 30 minutes in an ice bath, and then in an ice bath the reaction solution was added dropwise to a solution of compound 1-c (5.0 g, 17.6 mmol) in N, N-dimethylformamide (100 mE) slowly. The reaction mixture was reacted at 0 C. for 10 minutes, and then diluted with ethyl acetate (300 mE). The organic layer was separated, washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure, to obtain 20-d (4.0 g, 71.0%). EC-MS (ESI): mlz=342.9, 344.9 (M+H7.

The synthetic route of 930-62-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SHANGHAI YINGLI PHARMACEUTICAL CO., LTD; XU, Zusheng; (174 pag.)US2016/214994; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 930-62-1, name is 2,4-Dimethylimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C5H8N2

Preparation of 2-(2,4-dimethyl-1H-1-yl)benzonitrile Sodium hydride (8.65 g 60%, 0.216 mol) were stirred in anhydrous dimethylformamide in 75 . Thus in the 100 2,4- dimethyl DMF was added dropwise to a solution of imidazole (20.75 g, 0.216 mol). After stirring for 1 hour at room temperature, it was added dropwise a solution of benzonitrile (23.0 , 0.216 mol) of 2-fluoro-75 of DMF. This was stirred for 2 hours at 50 , was stirred at room temperature for 16 hours. The mixture was poured into water and the product was extracted with ethyl acetate. The organic layer was washed with water, dried over sodium sulfate. The crude product was 19: 1 dichloromethane-methanol followed by 9: 1 dichloromethane-treated by chromatography (silica gel) eluting with methanol to give the product as a solid. LCMS data were confirmed the structure.

The synthetic route of 2,4-Dimethylimidazole has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 930-62-1, name is 2,4-Dimethylimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H8N2

NaH (0.13 g; 3.3 mmol) was added portionwise to 2,4-dimethylimidazole (0.3 g; 3 mmol) in /V,/V-dimethylformamide (25 mL) at 5C under N2 flow. The reaction mixture was stirred at 5C for 30 minutes, then compound 236 (1 g; 2.4 mmol) was added at 5C under N2 flow. The reaction mixture was allowed to warm to room temperature and stirred for 18 hours. The reaction was poured out into ice water. The organic layer was separated and washed with water, dried (MgS04), filtered and the solvent was evaporated. The residue (1 .8 g) was purified by chromatography over silica gel (SiOH, 15-40mueta, 300 g; mobile phase 0.5% NH4OH, 95% DCM, 5% MeOH). The pure fractions were collected and concentrated. The residue (1 g) was purified by achiral super critical fluid chromatography (Amino thetamuetaiota; mobile phase 0.3% isopropylamine, 15% MeOH, 85% C02). The pure fractions were collected and the solvent was evaporated till dryness. The first fraction (0.44 g) was further purified by chromatography over silica gel (SiOH, 5mu?iota; mobile phase gradient from 0.4% NH4OH, 96% DCM, 4% MeOH to 1.5% NH4OH, 85% DCM, 15% MeOH). The pure fractions were collected and concentrated. The residue (0.38 g) was dissolved in acetone, then HCI 4N in dioxane was added dropwise. Diethyl ether was added and the precipitate was filtered and dried to afford 0.39 g (27%) of compound 692 . MP: 157C (DSC).The second fraction was dissolved in CH3CN, then HCI 4N in dioxane was added dropwise. The precipitate was filtered and dried to afford 0.1 1 g (8%) of compound 563 . MP: 201 C (DSC).

The synthetic route of 2,4-Dimethylimidazole has been constantly updated, and we look forward to future research findings.

Synthetic Route of 930-62-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 930-62-1 as follows.

1H-NMR(CDCl3,delta):1.47(3H,t,J=7.3 Hz),1.53(3H,t,J=7.3 Hz), 2.24(6H,s),4.23(3H,s),4.56(2H,q,J=7.3 Hz),4.66(2H,q,J=7.3 Hz), 6.66(1H,s),8.10(1H,s),8.44(1H,s).

According to the analysis of related databases, 930-62-1, the application of this compound in the production field has become more and more popular.