Category: 93-84-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 5-Nitro-1H-benzo[d]imidazol-2(3H)-one

Intermediate 301 was prepared from 5-nitro-1,3-dihydro-2H-benzo[d]imidazol-2-one 10 (CAS: 984-5) and bromoacetamide (CAS: 683-57-8) by the method indicated in the scheme below:

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 93-84-5.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; JOHNSON & JOHNSON (CHINA) INVESTMENT LTD.; DAI, Xuedong; QUEROLLE, Olivier Alexis Georges; KROSKY, Daniel Jason; CAI, Wei; FU, Liqiang; KONG, Linglong; LIU, Yingtao; WAN, Zhao-Kui; HERKERT, Barbara; PANDE, Vineet; EDWARDS, James Patrick; PATRICK, Aaron Nathaniel; ANGIBAUD, Patrick Rene; PONCELET, Virginie Sophie; (488 pag.)WO2019/120209; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 93-84-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

a 1,3-dimethyl-5-nitro-1,3-dihydrobenzimidazol-2-one 90 parts of 5-nitro-1,3-dihydrobenzimidazol-2-one are suspended in 500 parts of aqueous sodium hydroxide solution (30%) and the suspension is heated to 53 C.; 161 parts of dimethyl sulphate are added dropwise over 12 hours during which the temperature rises to 70 C. The mixture is cooled to room temperature and filtered and the solid product is washed to neutrality. Drying under reduced pressure at 80 C. gives 99 parts of a beige powder of a compound of the following formula Yield: 96% Melting point: 206.3 C. 1H-NMR (DMSO): delta: 3.35 (s, CH3)-3.37 (s,CH3)-7.28 (d, 3J=9 Hz, H-C7)-7.98 (d, 4J=2 Hz, H-C4)-8.00 (dd, 3J=9 Hz, 4J=2Hz, H-C6)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Clariant Finance (BVI) Limited; US6255482; (2001); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 93-84-5,Some common heterocyclic compound, 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C7H5N3O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Concentrated hydrochloric acid (5 drops) was added to a suspension of 5-nitro-1, 3-dihydrobenzimidazol-2-one (intermediate 10,0. 96g) in phosphorus oxychloride (25ml) and the mixture was stirred and heated at reflux for 7h. The cooled mixture was poured into a mixture of ice and water and the precipitated product was extracted into ethyl acetate. The organic phase was dried (MgSO4), filtered and the filtrate was evaporated to give 2-chloro-5-nitrobenzimidazole as a tan coloured solid (0.9g). ‘H NMR (DMSO-d6) d 14.0 (brs, 1H) 8.45 (brs, 1H) 8.15 (d, 1H) 7.7 (d, 1H)

The synthetic route of 93-84-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARGENTA DISCOVERY LTD.; WO2005/35526; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 93-84-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

a 1,3-dimethyl-5-nitro-1,3-dihydrobenzimidazol-2-one 90 parts of 5-nitro-1,3-dihydrobenzimidazol-2-one are suspended in 500 parts of aqueous sodium hydroxide solution (30%) and the suspension is heated to 53 C.; 161 parts of dimethyl sulphate are added dropwise over 12 hours during which the temperature rises to 70 C. The mixture is cooled to room temperature and filtered and the solid product is washed to neutrality. Drying under reduced pressure at 80 C. gives 99 parts of a beige powder of a compound of the following formula Yield: 96% Melting point: 206.3 C. 1H-NMR (DMSO): delta: 3.35 (s, CH3)-3.37 (s,CH3)-7.28 (d, 3J=9 Hz, H-C7)-7.98 (d, 4J=2 Hz, H-C4)-8.00 (dd, 3J=9 Hz, 4J=2Hz, H-C6)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Clariant Finance (BVI) Limited; US6255482; (2001); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 93-84-5, A common heterocyclic compound, 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C7H5N3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Concentrated hydrochloric acid (5 drops) was added to a suspension of 5-nitro-1, 3-dihydrobenzimidazol-2-one (intermediate 10,0. 96g) in phosphorus oxychloride (25ml) and the mixture was stirred and heated at reflux for 7h. The cooled mixture was poured into a mixture of ice and water and the precipitated product was extracted into ethyl acetate. The organic phase was dried (MgSO4), filtered and the filtrate was evaporated to give 2-chloro-5-nitrobenzimidazole as a tan coloured solid (0.9g). ‘H NMR (DMSO-d6) d 14.0 (brs, 1H) 8.45 (brs, 1H) 8.15 (d, 1H) 7.7 (d, 1H)

The synthetic route of 93-84-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARGENTA DISCOVERY LTD.; WO2005/35526; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 5-Nitro-1H-benzo[d]imidazol-2(3H)-one

Intermediate 301 was prepared from 5-nitro-1,3-dihydro-2H-benzo[d]imidazol-2-one 10 (CAS: 984-5) and bromoacetamide (CAS: 683-57-8) by the method indicated in the scheme below:

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 93-84-5.

Reference of 93-84-5, The chemical industry reduces the impact on the environment during synthesis 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, I believe this compound will play a more active role in future production and life.

5-Nitro-1,3-dihydro-2H-benzo[d]imidazol-2-one (0.837 mmol,1 eq, 0.15 g) was dissolved in ethanol (5 mL). SnCl2 ·2 H2O(4.187 mmol, 5 eq, 0.94 g) was added to the solution and the system was cooled to 0 C. Afterwards, 37% HCl (0.5 mL) was added dropwise.The reaction mixture was stirred at 0 C for 10 min, then itwas let warm to room temperature and then was heated to 75 C.The reaction mixture was stirred at this temperature for 3 h andthen left overnight (10 h) at room temperature. The next morning the reactionwas cooled to 0 C and quenched by dropwise additionof a saturated aqueous solution of NaHCO3 till pH 7-8. The product was extracted with ethyl acetate (3 x 10 mL). The combined organiclayers were washed with a saturated aqueous solution of NaCl(2 x 5 mL) and then dried over Na2SO4, filtered and concentrated invacuo. The extract was purified by silica gel chromatography elutingwith chloroform: methanol 8:1, to afford the amine 7; -benzo[d]imidazol-2-one (0.365 mmol, 54.5 mg, Y 44%). m.p. 253-256 C(methanol). 1H NMR (DMSO-d6, 400 MHz, delta; ppm) deltaH: 6.21-6.24(1H, dd, J = 2 Hz, 8.2 Hz, C(4)H), 6.29 (1H, d, J = 2 Hz, C(2)H), 6.63(1H, d, J = 8 Hz, C(5)H), 10.08 (1H, bs, N(1)H), 10.23 (1H, bs, N(2)H)ppm. 13C NMR (DMSO-d6, 100 MHz, delta; ppm) deltaC: 95.4, 106.7, 108.6,119.9, 130.2, 143.1, 156.4 ppm. MS (EI) m/z [M]+:149.07.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, other downstream synthetic routes, hurry up and to see.

Application of 93-84-5, These common heterocyclic compound, 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2) Preparation of 2-Chloro-5-nitro-1H-benzimidazole According to the procedure of A. T. James, et al., J. Chem. Soc., 1515 (1950), a mixture of 2-hydroxy-5-nitro-1H-benzimidazole (10.0 g, 0.0558 mol) and phosphoryl chloride (100 mL) was heated under reflux for 3 hours. The mixture was cooled, concentrated, and ice water was added. The resulting precipitate was collected by filtration. NMR analysis showed the material to be a 1:1 mixture of starting material and product. (Note: Longer heating does not improve the conversion.) Purification by flash chromatography (material preadsorbed onto silica; eluent 40% EtOAc/hexane) gave 4.4 g (40%) of the off-white solid product m.p. 215-217 C. NMR (DMSO-d6, 300 MHz): delta7.68 (d, J=8.9, 1H), 8.12 (dd, J=8.9, 2.3, 1H), 8.39 (d, J=2.3, 1H), 14.00 (brs, 1H).

The synthetic route of 93-84-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; American Home Products Corporation; US5149700; (1992); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H5N3O3

Preparation 10. 5-amino-1H-benzo[d]imidazol-2(3H)-one[358] A mixture of 5-nitro-2-benzimidazolinone (100 mg, 0.56 mmol), palladium/charcoal (10 mg, 10 wt%), and methanol/ethyl acetate (3 ml / 0.5 ml) was stirred at room temperature under hydrogen atmosphere overnight. The reaction mixture was filtered through a celite pad. The resulting filtrate was concentrated under reduced pressure. The resulting residue was purified with silica gel column chromatography (dichloromethane/methanol = 30/1) to give 85 mg of the titled compound as a red solid.[359] 1H-NMR(400MHz, CD3OD) delta 6.80(d, 1H), 6.52-6.47(m, 2H)

The synthetic route of 93-84-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; YUHAN CORPORATION; SIM, Jae-Young; CHA, Myung-Hun; KIM, Tae-Kyun; LEE, Hyun-Joo; YOON, Young-Ae; KIM, Dong-Hoon; AHN, Hee-Jeong; LEE, Tai-Au; AHN, Kyoung-Kyu; HYUN, Kwan-Hoon; WO2012/115479; (2012); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem