Adding a certain compound to certain chemical reactions, such as: 89250-15-7, name is 4-(1-Methyl-1H-imidazol-5-yl)aniline, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89250-15-7, SDS of cas: 89250-15-7
Reference Example 32 4-(3-Methyl-3H-imidazol-4-yl)phenylhydrazine 4-(3-Methyl-3H-imidazol-4-yl)phenylamine (430 mg) was dissolved in concentrated hydrochloric acid (4.0 ml), water (2.0 ml) and THF (2.0 ml), and an aqueous solution (2 ml) of sodium nitrite (206 mg) was added dropwise to the mixture under ice-cooling. After stirring for 40 minutes, a concentrated hydrochloric acid solution (3 ml) of tin chloride dihydrate (1.34 g) was added to the mixture, followed by stirring at room temperature for 2 hours. The reaction solution was alkalified by adding aqueous ammonia (28%), chloroform:methanol = 10:1 solution was added to the mixture and then filtered through celite. An organic layer of the filtrate was dried over anhydrous sodium sulfate, and the solvent was evaporated to obtain the title compound (289 mg) as a yellow solid. 1H-NMR (400 MHz, CDCl3) delta: 3.24 (2H, br s), 3.62 (3H, s), 5.34 (1H, br s), 6.88 (2H, d, J=8.8 Hz), 7.01 (1H, s), 7.24 (2H, d, J=8.8 Hz), 7.47 (1H, s).
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Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1612204; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem