Category: 872-49-1

872-49-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 872-49-1, name is 5-Chloro-1-methylimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

5-Chloro-1-methyl-imidazole (4.0 g, 34.32 mmol) was dissolved in a mixture of 4.0 g of conc. nitric acid and 14 mL of water, and concentrated in vacuo to give a yellow slurry. To this mixture was added dropwise 12 g of conc. sulfuric acid and heated to 95C for 2 hours. Upon cooling, ice was added to the reaction mixture, which was then left standing 10 hours at 5C. The white precipitation was collected by filtration, washed with water, recrystallized from ethanol and dried in vacuo to give compound 60A.

The synthetic route of 5-Chloro-1-methylimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Squibb Company; EP1066286; (2009); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 872-49-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 872-49-1, name is 5-Chloro-1-methylimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE IV 4-Chloro-1,3-dimethyl-2-[(2-oxopropyl)thio]-1H-imidazolium chloride STR60 The starting material, 4-chloro-1,3-dimethylimidazoline-2-thione was first prepared by adding dropwise and intimately admixing 5.68 grams (0.04 mol) of methyl iodide to a solution of 4.0 grams (0.0343 mol) of 5-chloro-1-methylimidazole in 25 milliliters of methylene chloride. The resulting mixture was stirred overnight at room temperature whereupon a crystalline product was found to have formed.

The synthetic route of 5-Chloro-1-methylimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck & Co., Inc.; US5030644; (1991); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 872-49-1, name is 5-Chloro-1-methylimidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloro-1-methylimidazole

An acetonitrile (6 ml) solution of 2,5-difluorobenzaldehyde (327 mul, 3 mmol), 5-chloro-1-methylimidazole (187 mug, 2 mmol) and di-t-butyl dicarbonate (504 mul, 2.2 mmol) was stirred at room temperature for 20 hours. The precipitate thus formed was collected by filtration, followed by trituration with hexane to give the title compound (472 mg, 66%) as a white solid. 1H-NMR (400MHz, CDCl3) delta: 1.48(9H,s), 3.67(3H,s), 6.88-7.1 (4H, m), 7.39 (1H, m). mp: 125 to 126C. MSm/z: 359 (M++H) .

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 872-49-1, The chemical industry reduces the impact on the environment during synthesis 872-49-1, name is 5-Chloro-1-methylimidazole, I believe this compound will play a more active role in future production and life.

Example 1 5-Chloro-1-methyl-4-imidazolesulfonic acid 33 g (0.28 mol) of 5-chloro-1-methylimidazole in 200 ml of fuming sulfuric acid are heated at 160-180 C. for 4 hours. After cooling, the reaction mixture is cautiously added to ice. The product crystallizes out from the cold aqueous solution (about 1.5 l). After recrystallizing twice from water, the title compound is obtained in the form of coarse yellowish crystals of melting point 309-310 C. Yield: 34 g (46.9% of theory).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-1-methylimidazole, other downstream synthetic routes, hurry up and to see.

872-49-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 872-49-1, name is 5-Chloro-1-methylimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

5-Chloro-1-methyl-imidazole (4.0 g, 34.32 mmol) was dissolved in a mixture of 4.0 g of conc. nitric acid and 14 mL of water, and concentrated in vacuo to give a yellow slurry. To this mixture was added dropwise 12 g of conc. sulfuric acid and heated to 95C for 2 hours. Upon cooling, ice was added to the reaction mixture, which was then left standing 10 hours at 5C. The white precipitation was collected by filtration, washed with water, recrystallized from ethanol and dried in vacuo to give compound 60A.

The synthetic route of 5-Chloro-1-methylimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Squibb Company; EP1066286; (2009); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The chemical industry reduces the impact on the environment during synthesis 872-49-1, name is 5-Chloro-1-methylimidazole, I believe this compound will play a more active role in future production and life. 872-49-1

General procedure: 2-Chloropyrazine(0.64 g, 5.56 mmol), tetrakis(triphenylphosphine) palladium(0)(96 mg, 0.083 mmol), and potassium carbonate (0.77 g,5.56 mmol) were added to a solution of 22 (1.16 g, 2.78 mmol)in a mixed solvent of DMF-EtOH (2 : 1, 18 mL), and the mixturewas stirred at 90C for 2 h. The reaction solution was partitionedbetween water and EtOAc, and the organic layer waswashed with water and brine, dried over anhydrous MgSO4,filtered, and concentrated in vacuo. The residue was purifiedusing silica gel column chromatography (33-67% EtOAc inhexane) to yield 23a (0.79 g, 77%) as a colorless amorphous.

The chemical industry reduces the impact on the environment during synthesis 872-49-1. I believe this compound will play a more active role in future production and life.

Reference:
Article; Yamamoto, Shuji; Shibata, Tsuyoshi; Abe, Kumi; Oda, Koji; Aoki, Takeshi; Kawakita, Yasunori; Kawamoto, Hiroshi; Chemical and Pharmaceutical Bulletin; vol. 64; 9; (2016); p. 1321 – 1337;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem