Category: 870837-18-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

Synthesis of (Z)-2-[1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene]-4-(3,4,5-trifluorobenzyl)morpholin-3-one Thionyl chloride (16.1 mL) was added to a solution of 2-hydroxy-4-(3,4,5-trifluorobenzyl)morpholin-3-one (3.94 g) in methylene chloride, and the reaction solution was stirred at 50 C. for one hour. The reaction solution was concentrated under reduced pressure, and the residue was diluted with methylene chloride. Then, triphenylphosphine (5.2 g) was added under ice-cooling, and the reaction solution was stirred at room temperature for 4.5 hours. The reaction solution was concentrated under reduced pressure. Ethanol (64.6 mL), TEA (4.2 mL), and 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde (2.72 g) were added to the residue, and the reaction solution was heated under reflux for two hours. The reaction solution was concentrated under reduced pressure, and the residue was diluted with 2 N aqueous hydrochloric acid and ethyl acetate. Then, the aqueous layer was separated. The organic layer was washed with 2 N aqueous hydrochloric acid. Then, the total aqueous layers were combined and made alkaline with a concentrated sodium hydroxide solution. The organic layer was separated by extraction from the alkaline solution with chloroform, and then dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography using NH silica gel (heptane:ethyl acetate=1:1 to 0:100) to obtain 1.92 g of the title compound. 1H-NMR (CDCl3) delta (ppm): 2.34(s,3H), 3.56(t,J=4.8 Hz,2H), 3.87(s,3H), 4.28(t,J=4.8 Hz,2H), 4.66(s,2H), 6.93(s,1H), 6.95-6.99(m,3H), 7.23(d,J=8.0 Hz,1H), 7.40(dd,J=8.0,1.2 Hz,1H), 7.42(d,J=1.2 Hz,1H), 7.85(s,1H).

The synthetic route of 870837-18-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2007/117798; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, A new synthetic method of this compound is introduced below., Recommanded Product: 870837-18-6

To a solution of intermediate 66 (500 mg, 1.63 mmol) in THF (1 ml) at -75 C was added n-butyl lithium (0.65 ml, 1.63 mmol, 2.5 M in hexanes). The r.m. was stirred for 1 min. at -75 C after which a solution of intermediate 67 (283 mg, 1.31 mmol) in THF (1 ml) was added. The r.m.was then stirred at -75 C for 60 min. and quenched by the addition of a sat. aq. solution of NH4CI (5 ml). The reaction was allowed to warm to r. t. and concentrated under reduced pressure. The residue was purified by flash column chromatography over silica gel (eluent: DCM/MeOH(NH3) from 100/0 to 99/1). The product fractions were collected and concentrated in vacuo, yielding 150 mg of intermediate 68 (21 %).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; VAN BRANDT, Sven, Franciscus, Anna; DE CLEYN, Michel, Anna, Jozef; GIJSEN, Henricus, Jacobus, Maria; BERTHELOT, Didier, Jean-Claude; SURKYN, Michel; WO2011/86099; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 870837-18-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step B: To a solution of 1 10 mg (0.497 mmol) of 1 -(1 -(4-fluorophenyl)ethyl)piperidin-2- one A6a in THF (2 ml) was added 1 .24 mL of 2M LDA (in THF/Heptane, Acros) at -78 C. The reaction was stirred for 30 min at -78 C, then stirred for 30 min at -20 C, and was re-cooled to -78 C. Added 3-methoxy-4-(4-methyl-1 H-imidazol-1 – yl)benzaldehyde as solid and stirred for 30 min. The mixture was quenched with saturated aqueous NaHCtheta3, extracted with EtOAc (2 times), and washed with brine (2X). The organic phase was dried (MgSO4) and concentrated. The product was purified by a gradient reverse-phase HPLC (CH3CN-H2O with 0.1% formic acid) to furnish 1 10 mg of the product A6. (ES-LCMS, M+1) 438.2. Retention time: 2.94 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SCHERING CORPORATION; WO2009/108766; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C12H12N2O2

Method Aq, Step 6:Comopund Aq6 (0.46 g) in CICH2CH2CIZMeCN (20 rnL, 1/1) was treated with PPh3-HBr (0.73 g) and heated for 5 hours before solvent was removed. The residue was taken up in THF/DMF (27.5 mL, 10/1 ) and 3-rnethoxy~4-(1-(4- methylinidazolyf))benza.de?yde (0.29 g) was added. The mixture was cooled to 0 0C and LHMDS (4.5 mL, 1.0 M in THF) was added dropwise. The mixture was stirred at 0 0C for 1 hour and then room temperature for 1 hour before NH4CI was added to quench the reaction. The residue was diluted with EtOAc. The aqueous layer was extracted with EtOAc. The organic layer was washed with water, brine, dried over MgSO4, and concentrated to give the crude product which was purified by column chromatography etuting with EtOAc/hexanes to yield compound Aq7 (0.13 g).

The synthetic route of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; ZHU, Zhaoning; GREENLEE, William J.; HUANG, Xianhai; QIN, Jun; LIU, Xiaoxiang; LI, Hongmei; ZHOU, Wei; PALANI, Anandan; ZHU, Xiaohong; VICAREL, Monica L.; MANDAL, Mihirbaran; SUN, Zhong-Yue; BENNETT, Chad E.; MCCRACKEN, Troy M.; GALLO, Gioconda; WO2010/56849; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem