Category: 86718-07-2

Adding a certain compound to certain chemical reactions, such as: 86718-07-2, name is Ethyl 4-(1-Imidazolyl)benzoate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 86718-07-2, HPLC of Formula: C12H12N2O2

Alternatively the 4-(1-imidazolyl)-benzylalcohol can be obtained by reduction of the ethyl 4-(1-imidazolyl)-benzoate with LiAlH4. The 4-(1-imidazolyl)-benzylalcohol thus obtained is solved in diethyl ether and transformed into the corresponding hydrochloride by bubbling gaseous HCl.

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Reference:
Patent; Farmitalia Carlo Erba S.R.L.; US5238953; (1993); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 86718-07-2,Some common heterocyclic compound, 86718-07-2, name is Ethyl 4-(1-Imidazolyl)benzoate, molecular formula is C12H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 2 N-(4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl)-4-(imidazol-1-yl) benzamide Ethyl 4-(imidazol-1-yl)benzoate (0.5 g, 2.3 mmol) was heated at reflux in 5N HCl (40 ml) for 1 h, evaporated to dryness under reduced pressure and the resulting white solid dried in vacuo to afford 4-(imidazol-1-yl)benzoic acid This was suspended in dry toluene (40 ml) and thionyl chloride (2 ml) added under argon. The mixture was heated to reflux for 1.5 h and then evaporated to dryness under reduced pressure. The oil was dissolved in dichloromethane under argon and 4-methoxy-3-(4-methyl-1-piperazinyl)phenylamine (551 mg, 2.3 mmol) was added followed by triethylamine (2 ml). The mixture was stirred at room temperature under argon for 2 h and then partitioned between dichloromethane (50 ml) and saturated potassium carbonate (50 ml), and the organic extracts dried (sodium sulphate). The organic solution was filtered, evaporated to dryness under reduced pressure and purified by column chromatography (silica, chloroform/methanol 5-10%) to afford the amide (809 mg, 90%) which was crystallized from methanol diethyl ether as the oxalate salt. 1H NMR (CDCl3) (free base) delta: 2.38 (3H, s), 2.66 (4H, bm), 3.15 (4H, bm), 3.90 (3H, s), 6.87 (1H, d), 7.29 (2H, m), 7.37 (1H, s), 7.52 (2H, d), 7.86 (1H, s), 7.93 1H, s), 8.01 (2H, d).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-(1-Imidazolyl)benzoate, its application will become more common.

Reference:
Patent; SmithKline Beecham p.l.c.; US5834471; (1998); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem