Category: 866926-59-2

Product Details of 866926-59-2On October 14, 2005 ,《Room-Temperature Negishi Cross-Coupling of Unactivated Alkyl Bromides with Alkyl Organozinc Reagents Utilizing a Pd/N-Heterocyclic Carbene Catalyst》 was published in Journal of Organic Chemistry. The article was written by Hadei, Niloufar; Kantchev, Eric Assen B.; O’Brien, Christopher J.; Organ, Michael G.. The article contains the following contents:

A high-yielding cross-coupling reaction of unactivated alkyl bromides possessing β-hydrogens with alkylzinc halides utilizing a Pd/N-heterocyclic carbene (NHC) catalyst at room temperature is described. A variety of Pd sources, Pd2(dba)3, Pd(OAc)2, or PdBr2, with the com. available ligand precursor 1,3-bis(2,6-diisopropylphenyl)imidazolium chloride successfully coupled 1-bromo-3-phenylpropane with n-butylzinc bromide in THF/NMP. An investigation of different NHC precursors showed that the bulky 2,6-diisopropylphenyl moiety was necessary to achieve high coupling yields (75-85%). The corresponding Et analog was moderately active (11%). A range of unsym. NHC precursors were prepared and evaluated. The ligand precursor containing one 2,6-diisopropylphenyl and one 2,6-diethylphenyl afforded the coupling product in 47% yield, clearly suggesting a direct relationship between the steric topog. created by the flanking N-substituents and catalyst activity. Under optimal conditions, a number of alkyl bromides and alkylzinc halides possessing common functional groups (amide, nitrile, ester, acetal, and alkyne) were effectively coupled (61-92%). It is noteworthy that β-substituted alkyl bromides and alkylzinc halides successfully underwent cross-coupling. Also, under these conditions alkyl chlorides were unaffected. In the part of experimental materials, we found many familiar compounds, such as 1-(2,6-Diisopropylphenyl)-3-mesityl-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 866926-59-2Product Details of 866926-59-2)

1-(2,6-Diisopropylphenyl)-3-mesityl-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 866926-59-2) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Product Details of 866926-59-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wenzel, Anna G.; Grubbs, Robert H. published their research in Journal of the American Chemical Society on December 20 ,2006. The article was titled 《Ruthenium Metallacycles Derived from 14-Electron Complexes. New Insights into Olefin Metathesis Intermediates》.HPLC of Formula: 866926-59-2 The article contains the following contents:

Ru(IV) metallacycles derived from both ethylene and propene are reported. The propene-derived metallacycles represent the 1st observed examples of substituted ruthenacyclobutanes and offer new insight into the preferred stereochem. orientation about metathesis intermediates. The authors showed evidence supporting the bottom-face orientation of Ru(IV) metallacycles derived from both ethylene and propene. The unsym. disubstituted 1-(2,6-diisopropylphenyl)-3-(2,4,6-trimethylphenyl)-4,5-dihydroimidazolinium chloride ([H2ImesiPrH]+Cl-) and the ruthenium carbene complex [(H2ImesiPr)Ru(:CHPCy3)(Cl)2]+[BF4]- were prepared The mol. structure of the ruthenium carbene complex was determined by x-ray crystallog. Reaction of the ruthenium carbene complex with ethylene gave a ruthenacyclobutane possessing an unsym. N-heterocyclic carbene (NHC) ligand. The complex was studied to ascertain the dynamics of the NHC relative to the metallacycle ring. Ruthenacyclobutanes studied possess exchange cross-peaks between the α- and β-positions in the 2-dimensional NMR, indicating a dynamic structure. The ruthenacyclobutanes derived from ethylene and propene proceed through nonproductive metallacycle formations/cycloreversions prior to olefin exchange. The implications of these results to the mechanism of Ru-catalyzed olefin metathesis are discussed. In the part of experimental materials, we found many familiar compounds, such as 1-(2,6-Diisopropylphenyl)-3-mesityl-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 866926-59-2HPLC of Formula: 866926-59-2)

1-(2,6-Diisopropylphenyl)-3-mesityl-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 866926-59-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.HPLC of Formula: 866926-59-2 Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem