Category: 865774-07-8

Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s disease was written by Brodney, Michael A.;Auperin, David D.;Becker, Stacey L.;Bronk, Brian S.;Brown, Tracy M.;Coffman, Karen J.;Finley, James E.;Hicks, Carol D.;Karmilowicz, Michael J.;Lanz, Thomas A.;Liston, Dane;Liu, Xingrong;Martin, Barbara-Anne;Nelson, Robert B.;Nolan, Charles E.;Oborski, Christine E.;Parker, Christine P.;Richter, Karl E. G.;Pozdnyakov, Nikolay;Sahagan, Barbara G.;Schachter, Joel B.;Sokolowski, Sharon A.;Tate, Barbara;Van Deusen, Jeffrey W.;Wood, Douglas E.;Wood, Kathleen M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Recommanded Product: Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate The following contents are mentioned in the article:

The synthesis and structure-activity relationship (SAR) of a novel series of di-substituted imidazoles, e.g. I (R = n-Pr, Me, i-Bu, s-Bu, Ph), derived from modification of DAPT, are described. Subsequent optimization led to identification of a highly potent series of inhibitors that contain a β-amine in the imidazole side-chain resulting in a robust in vivo reduction of plasma and brain Aβ in guinea pigs. The therapeutic index between Aβ reductions and changes in B-cell populations were studied for compound aminoimidazole II. This study involved multiple reactions and reactants, such as Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate (cas: 865774-07-8Recommanded Product: Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate).

Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate (cas: 865774-07-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014 was written by Brodney, Michael A.;Auperin, David D.;Becker, Stacey L.;Bronk, Brian S.;Brown, Tracy M.;Coffman, Karen J.;Finley, James E.;Hicks, Carol D.;Karmilowicz, Michael J.;Lanz, Thomas A.;Liston, Dane;Liu, Xingrong;Martin, Barbara-Anne;Nelson, Robert B.;Nolan, Charles E.;Oborski, Christine E.;Parker, Christine P.;Richter, Karl E. G.;Pozdnyakov, Nikolay;Sahagan, Barbara G.;Schachter, Joel B.;Sokolowski, Sharon A.;Tate, Barbara;Wood, Douglas E.;Wood, Kathleen M.;Van Deusen, Jeffrey W.;Zhang, Lei. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Safety of Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate The following contents are mentioned in the article:

A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding Ph acetic acid derivatives is described. Replacement of the amide led to identification of a potent series of tetralin-amino imidazoles with robust central efficacy. The reduction of brain Aβ in guinea pigs in the absence of changes in B-cells suggested a potential therapeutic index with respect to APP processing compared with biomarkers of notch related toxicity. Optimization of the FTOC to plasma concentrations at the brain Aβ EC₅₀ lead to the identification of compound I (PF-3084014) which was selected for clin. development. This study involved multiple reactions and reactants, such as Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate (cas: 865774-07-8Safety of Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate).

Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate (cas: 865774-07-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Safety of Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem