Category: 857070-66-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 857070-66-7, name is (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, A new synthetic method of this compound is introduced below., Recommanded Product: (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol

A mixture of b-3 (0.069 mol) and N-propylamino-morpholine (0.207 mol) was stirred at 125C for 4 hours, and then taken up in CH2C12/CH3OH. The organic layer was washed with a 10% solution OfK2CO3 in water, dried (over MgSO4), filtered and the solvent was evaporated until dryness. The residue (37 g) was purified by column chromatography over silica gel (eluent: CH2C12/CH3OH/NH4OH 90/10/0.5; 20-45mum). The pure fractions were collected and the solvent was evaporated, yielding 16.5g of intermediate b-4 (82%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD; WO2006/136562; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 857070-66-7, name is (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, A new synthetic method of this compound is introduced below., Application In Synthesis of (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol

A mixture of b-3 (0.069 mol) and N-propylamino-morpholine (0.207 mol) was stirred at 125C for 4 hours, and then taken up in CH2C12/CH3OH. The organic layer was washed with a 10% solution OfK2CO3 in water, dried (over MgSO4), filtered and the solvent was evaporated until dryness. The residue (37 g) was purified by column chromatography over silica gel (eluent: CH2C12/CH3OH/NH4OH 90/10/0.5; 20-45mum). The pure fractions were collected and the solvent was evaporated, yielding 16.5g of intermediate b-4 (82%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD; WO2006/136562; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

857070-66-7, name is (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol

A mixture of u-7 (0.0085 mol) and u-6 (0.0255 mol) was stirred at 120C for 4 hours. A 10% solution of K2C03 in water was added. The aqueous layer was saturated with K2C03 (powder). The mixture was extracted with CH2Cl2. The organic layer was separated, dried (over MgS04), filtered and the solvent was evaporated. The residue (4.1 g) was purified by column chromatography over silica gel (eluent: CH2C12/ CH30H/NH4OH 90/10/1; 15-40um). The pure fractions were collected and the solvent was evaporated, yielding 1.6 g of intermediate u-8 (59%).

The synthetic route of 857070-66-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/58871; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 857070-66-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 857070-66-7 name is (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of x-4 (0.0173 mol) and x-3 (0.026 mol) was stirred at 125C for 4 hours, and then taken up in CH2CI2/CH30H. The organic layer was washed with saturated K2C03 solution, dried (over MgSO4), filtered and the solvent was evaporated until dryness. The residue (9 g) was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH/NH4OH 90/10/0. 5; 20-45mum). Two fractions were collected and the solvent was evaporated. Yield: 0.7 g of intermediate x-5 (10%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/58871; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 857070-66-7, name is (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, A new synthetic method of this compound is introduced below., Safety of (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol

A mixture of m-1 (0.0273 mol) and m-2 (0.1095 mol) was stirred at 125C for 5 hours and then poured into a 10% solution OfK2CO3. The solution was saturated with K2CO3 (powder) and extracted with CH2CyCH3OH. The organic layer was separated, dried (over MgSO4), filtered and the solvent was evaporated. The residue (16 g) was purified by column chromatography over silica gel (eluent: CH2C12/CH3OH/NH4OH 88/12/0.5; 20-45 mum). The pure fractions were collected and the solvent was evaporated, yielding 5.4 g of intermediate m-3 (71%, melting point: 173C).

The synthetic route of 857070-66-7 has been constantly updated, and we look forward to future research findings.