Application of 857035-29-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 857035-29-1, name is Ethyl 2-chloro-1H-benzo[d]imidazole-6-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
LiAlH4 (0. 146 mol) was added portion wise to a solution of tetrahydrofuran (200 ml) at 5C under N2 flow. A solution of b-1 (0.073 mol) in tetrahydrofuran (200 ml) was then added drop wise. The mixture was stirred at 5C for 3 hours. A minimum of H20 was then added, followed by a solution of CH2Cl2/CH30H (90/10). The resulting mixture was dried (over MgSO4), filtered and the solvent was evaporated until dryness, yielding 12.6 g of intermediate b-2 (95%, melting point: 179C).
The synthetic route of Ethyl 2-chloro-1H-benzo[d]imidazole-6-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/58871; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem