Category: 85692-37-1

Preparation of imidazole and imidazolium 2-carbaldehydes was written by Ricciardi, Fiore;Joullie, Madeleine M.. And the article was included in Organic Preparations and Procedures International in 1983.Recommanded Product: 85692-37-1 This article mentions the following:

1,3-Dimethylimidazolium iodide (I) was converted to acylation products II (R = Me, H). Thus, HCO₂Et was added to I and K₂CO₃ in Me₂CO, and the mixture was stirred overnight to give II (R = H). II were heated with Me₃SiI in sulfolane to give bases III. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Recommanded Product: 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dual Heterogeneous Catalysis for a Regioselective Three- Component Synthesis of Bi- and Tri(hetero)arylpyridines was written by Allais, Christophe;Lieby-Muller, Frederic;Constantieux, Thierry;Rodriguez, Jean. And the article was included in Advanced Synthesis & Catalysis in 2012.HPLC of Formula: 85692-37-1 This article mentions the following:

We have designed a new, user-friendly oxidative dual heterogeneous catalytic system capable of promoting polysubstituted pyridines as unique products from simple activated Michael acceptors, 1,3-dicarbonyls, and ammonium acetate. This metal-free environmentally respectful, and totally regioselective domino reaction proved to be a great strategy to access bi- and triaryl-type pyridines as well as challenging bi- and triheteroaryl-type pyridines in a single operation. E.g., in presence of 4Å mol. sieves, activated carbon, and O₂, reaction of PhCH:CHCO₂Me and Me acetoacetate gave 91% biarylpyridine (I). In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1HPLC of Formula: 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Syntheses of 伪,尾-unsaturated ketones starting from vinylic and allylic Grignard reagents via 2-imidazolylmethanol intermediates was written by Hayakawa, Satoshi;Michiue, Toru;Okamoto, Masao;Hatakeyama, Shoko;Ohta, Shunsaku. And the article was included in Heterocycles in 1988.Recommanded Product: 85692-37-1 This article mentions the following:

The title unsaturated ketones, e.g., E-RCOCH:CHR¹ [I; R = R¹ = Ph; R = Me(CH₂)₅, Me₂C:CHCH₂CH₂CHMeCH₂, R¹ = Me] were prepared from acylimidazoles II and R¹CH:CHBr (III). Thus, Grignard reaction of II and III gave 92-100% imidazolylmethanols IV. Quaternization of IV with Me₂SO₄ followed by elimination with K₂CO₃ gave 87-90% I. Similarly, Grignard reactions of II [R = Me(CH₂)₅, cyclohexyl, Ph] with R²CH:CHCH₂Cl (R² = H, Me, Ph) gave hydroxyimidazoles V which were cleaved to give RCOCHR²CH:CH₂. Acidic isomerization gave RCOCR²:CHMe. This methodol. was used to prepare (卤)-(ar)-turmerone 4-MeC₆H₄CHMeCH₂COCH:CMe₂ in 5 steps from II (R = Me), p-MeC₆H₄CHO, and CH₂:CMeCH₂Cl. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Recommanded Product: 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Modular design of G-quadruplex metalloDNAzymes for catalytic C-C bond formations with switchable enantioselectivity was written by Punt, Philip M.;Langenberg, Marie D.;Altan, Okan;Clever, Guido H.. And the article was included in Journal of the American Chemical Society in 2021.COA of Formula: C6H8N2O This article mentions the following:

Metal-binding DNA structures with catalytic function are receiving increasing interest. Although a number of metalloDNAzymes have been reported to be highly efficient, the exact coordination/position of their catalytic metal center is often unknown. Here, we present a new approach to rationally develop metalloDNAzymes for Lewis acid-catalyzed reactions such as enantioselective Michael additions Our strategy relies on the predictable folding patterns of unimol. DNA G-quadruplexes, combined with the concept of metal-mediated base-pairing. Transition-metal coordination environments were created in G-quadruplex loop regions, accessible by substrates. Therefore, protein-inspired imidazole ligandoside L was covalently incorporated into a series of G-rich DNA strands by solid-phase synthesis. Iterative rounds of DNA sequence design and catalytic assays allowed us to select tailored metalloDNAzymes giving high conversions and excellent enantioselectivities (鈮?9%). Based on their primary sequence, folding pattern, and metal coordination mode, valuable information on structure-activity relationships could be extracted Variation of the number and position of ligand L within the sequence allowed us to control the formation of (S) and (R) enantiomeric reaction products, resp. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1COA of Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A visible-light-activated rhodium complex in enantioselective conjugate addition of 伪-amino radicals with Michael acceptors was written by Lin, Shao-Xia;Sun, Gui-Jun;Kang, Qiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Synthetic Route of C6H8N2O This article mentions the following:

We report an efficient enantioselective conjugate addition of photogenerated 伪-amino radicals to Michael acceptors catalyzed by a newly prepared chiral-at-metal rhodium complex. This protocol shows that a single Rh(III) complex can serve not only as a Lewis acid but also as a photoredox catalyst to control the stereoselectivity during the bond formation. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Synthetic Route of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole Derivatives as Accelerators for Ruthenium-Catalyzed Hydroesterification and Hydrocarbamoylation of Alkenes: Extensive Ligand Screening and Mechanistic Study was written by Konishi, Hideyuki;Muto, Takashi;Ueda, Tsuyoshi;Yamada, Yayoi;Yamaguchi, Miyuki;Manabe, Kei. And the article was included in ChemCatChem in 2015.Related Products of 85692-37-1 This article mentions the following:

Imidazole derivatives are effective ligands for promoting the [Ru₃(CO)₁₂]-catalyzed hydroesterification of alkenes using formates. Extensive ligand screening was performed to identify 2-hydroxymethylated imidazole as the optimal ligand. Neither carbon monoxide gas nor a directing group was required, and the reaction also showed a wide substrate generality. The Ru-imidazole catalyst system also promoted intramol. hydrocarbamoylation to afford lactams. A Ru-imidazole complex was unambiguously analyzed by x-ray crystallog., and it had a trinuclear structure derived from one [Ru₃(CO)₁₂] and two ligands. This complex was also successfully used for hydroesterification. The mechanism was examined in detail by using D- and ¹³C-labeled formates, indicating that the hydroesterification reaction proceeds by a decarbonylation-recarbonylation pathway. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Related Products of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enantioselective conjugate addition of hydroxylamines to 伪,尾-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal Rh(III) complex was written by Deng, Tao;Thota, Ganesh Kumar;Li, Yi;Kang, Qiang. And the article was included in Organic Chemistry Frontiers in 2017.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

A catalytic enantioselective hydroxyamination of 伪,尾-unsaturated 2-acyl imidazoles with N-protected hydroxyl amines catalyzed by a chiral-at-metal Rh(III) complex (0.5-2 mol%) has been developed. The approach affords valuable N-Boc protected 尾-amino acid derivatives I (R¹ = Me, i-Pr, Ph; R² = Me, Ph, 3-MeC₆H₄, etc.) in moderate to good yields with high enantioselectivity (up to 94% yield, 99.5% ee). In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

DNA vs. Mirror Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA-Based Asymmetric Catalysis was written by Wang, Jocelyn;Benedetti, Erica;Bethge, Lucas;Vonhoff, Stefan;Klussmann, Sven;Vasseur, Jean-Jacques;Cossy, Janine;Smietana, Michael;Arseniyadis, Stellios. And the article was included in Angewandte Chemie, International Edition in 2013.Electric Literature of C6H8N2O This article mentions the following:

In the presence of DNA oligomers containing D-ribose or L-ribose sugar backbones such as 5′-dTCAGGGCCCTGATCAGGGCCCTGA-3′, and (4,4′-dimethyl-2,2′-bipyridine)copper(II) nitrate, alkenoylimidazoles I (R = Me, Ph, 2-BrC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 2-furanyl) underwent enantioselective Friedel-Crafts and addition reactions with N-methylindole, 5-methoxyindole, di-Me malonate, and nitromethane to give addition products such as imidazolyloxopropylmalonates II (R = Ph, 2-BrC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 2-furanyl) in 58-90% ee for Friedel-Crafts reactions and in 67-99% for Michael addition reactions. D-ribose or L-ribose sugar backbone-containing DNA oligomers gave enantiomeric products; the enantioselectivity depended on the DNA sequence, with reactions using the DNA sequence 5′-dCAGTCAGTACTGACTGCAGTCAGTACTGACTG-3′ giving lower enantioselectivities. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Electric Literature of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Direct Access to Highly Enantioenriched 伪-Branched Acrylonitriles through a One-Pot Sequential Asymmetric Michael Addition/Retro-Dieckmann/Retro-Michael Fragmentation Cascade was written by Duchemin, Nicolas;Cattoen, Martin;Gayraud, Oscar;Anselmi, Silvia;Siddiq, Bilal;Buccafusca, Roberto;Daumas, Marc;Ferey, Vincent;Smietana, Michael;Arseniyadis, Stellios. And the article was included in Organic Letters in 2020.COA of Formula: C6H8N2O This article mentions the following:

A highly enantioselective synthesis of 伪-branched acrylonitriles is reported featuring a one-pot sequential asym. Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. The method, which relies on a solid, bench-stable, and com. available acrylonitrile surrogate, is practical, scalable, and highly versatile and provides a direct access to a wide range of enantioenriched nitrile-containing building blocks. Most importantly, the method offers a new tool to incorporate an acrylonitrile moiety in an asym. fashion. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1COA of Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Diastereoselective Trapping of Transient Carboxylic Oxonium Ylides with 伪,尾-Unsaturated 2-Acyl Imidazoles was written by Zhang, Mengchu;Zhang, Tianyuan;Zhang, Dan;Hu, Wenhao. And the article was included in Advanced Synthesis & Catalysis in 2020.Safety of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:

A diastereoselective reaction of cyclopropene carboxylic acids with 伪,尾-unsaturated 2-acyl imidazoles was developed to report a Michael-type trapping of transient carboxylic oxonium ylides. This transformation provided a direct approach for the construction of valuable 纬-butenolide derivatives I [R¹ = Ph, 4-FC₆H₄, 3,4,5-trimethoxyphenyl, etc.; R² = Ph, 2-furyl, 4-NCC₆H₄, etc.] in good yields (60-99%) with high diastereoselectivities (up to >95:5 dr) under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Safety of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 1-(1-Methyl-1H-imidazol-2-yl)ethanone

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem