Category: 84243-58-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 84243-58-3, name is 6-(4-(1H-Imidazol-1-yl)phenyl)-4,5-dihydropyridazin-3(2H)-one, This compound has unique chemical properties. The synthetic route is as follows., category: imidazoles-derivatives

To this mixture is added toluene (25mL), and the mixture is stirred, and the precipitated crystals are collected by filtration to give crude ethyl 6-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazole-1-carboxylate. Subsequently, to a suspension of ethyl 6-bromo-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazole-1-carboxylate (2.88 g, 9.63 mmol) in methanol (70 mL) is added a 5N aqueous sodium hydroxide solution (4 mL), and the mixture is stirred at 20-25C for 30 minutes. The reaction solution is concentrated under reduced pressure, and water (50 mL) is added to the residue, and thereto is added a 4N aqueous hydrochloric acid solution until the pH value of the mixture becomes pH 1. The resulting suspension is stirred for 30 minutes, and filtered. The product remained on the filter is dried under reduced pressure at 50C. The obtained solid is suspended in toluene (25 mL), and heated to 110C, and further gradually cooled to 20-25C. The insoluble product is collected by filtration, and dried under reduced pressure to give 5-bromo-1-methyl-1,3-dihydro-2H-benzimidazol-2-one (1.29 g).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 84243-58-3.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP1719761; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 84243-58-3, A common heterocyclic compound, 84243-58-3, name is 6-(4-(1H-Imidazol-1-yl)phenyl)-4,5-dihydropyridazin-3(2H)-one, molecular formula is C13H12N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 4 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone Bromine (1.6 ml) is added dropwise to a solution of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone (3.5 g) in acetic acid (25 ml) at 80 C. The mixture is heated for 5 to 6 hours to complete the reaction. The solid is filtered, washed with ether and converted to the free base which is crystallized from ethanol to yield 1.1 g of the product 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone: mp. 244-245 C. Anal. calcd for C13 H10 N4 O.1/5H2 O; C, 64.56; H, 4.30; N, 23.17; H2 O, 1.49. Found; C, 64.30; H, 4.36; N, 23.04; H2 O, 1.11.

The synthetic route of 84243-58-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Warner-Lambert Company; US4353905; (1982); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem