Category: 83279-44-1

Synthetic Route of 83279-44-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 83279-44-1, name is 1H-Imidazol-1-amine hydrochloride belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

(d) 0.48 g of 1-aminoimidazole hydrochloride are suspended in 30 ml of ethanol, whereupon 0.93 g of 4-hydroxy-3,5-di-tert.-butylbenzaldehyde is added. The suspension is stirred at room temperature for 3 hours, whereby there results a clear solution which is evaporated in a vacuum. The residue is taken up in 15 ml of water, neutralized (pH=7) with ice-cold saturated sodium bicarbonate solution and extracted rapidly three times with 30 ml of methylene chloride each time. The combined organic phases are dried over sodium sulfate, filtered and evaporated in a vacuum. By sublimation of the residue (160/12 Torr), there is obtained 1-(4-hydroxy-3,5-di-tert.-butylbenzylideneamino)imidazole of m.p. 171-174.

The synthetic route of 1H-Imidazol-1-amine hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; US4908363; (1990); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 83279-44-1, The chemical industry reduces the impact on the environment during synthesis 83279-44-1, name is 1H-Imidazol-1-amine hydrochloride, I believe this compound will play a more active role in future production and life.

EXAMPLE 8 1.20 g of 1-aminoimidazole hydrochloride are melted together with 2.70 g of 4-hydroxy-3,5-di-tert.-butylbenzoyl chloride on an oil-bath (about 200-210 bath temperture), whereby a vigorous gas evolution occurs. After 40 minutes, the solid residue is triturated with hot diisopropyl ether and filtered. The filter residue is taken up in water, treated with saturated sodium bicarbonate solution up to an alkaline reaction and extracted three times with methylene chloride. The combined organic extracts are dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure on a rotary evaporator. The residue is taken up in ethyl acetate, heated and the 1-(4-hydroxy-3,5-di-tert.-butylbenzoylamino)imidazole is precipitated while hot with n-hexane. The precipitate is removed by filtration, washed once with n-hexane/ethyl acetate (2:1) and dried at 50 in a high vacuum; m.p. 245 (dec.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazol-1-amine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hoffmann-La Roche Inc.; US4908363; (1990); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem