Category: 827-43-0

Electric Literature of 827-43-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 827-43-0 name is 4-Methyl-2-phenyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Into a 15mL pressure tube, sequentially add 1o (47.5mg, 0.3mmol), dichloromethane (3mL), 2a (84.7mg, 0.45mmol), dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer (4.7mg, 0.0075 mmol) and silver acetate (100.1 mg, 0.6 mmol), then the pressure-resistant tube was sealed and placed in a 100 C. oil bath for 10 h. After the reaction was completed, the mixture was cooled to room temperature, filtered with suction, dried, and separated through a silica gel column (dichloromethane / methanol / acetic acid = 30/1 / 0.1) to obtain 3o (67.2 mg, 65%) as a white solid product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Methyl-2-phenyl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Patent; Henan Normal University; Zhang Xinying; Zhang Linghua; Xu Yuanshuang; Fan Xuesen; (23 pag.)CN110372708; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 827-43-0, These common heterocyclic compound, 827-43-0, name is 4-Methyl-2-phenyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of bicyclic olefin 2a (0.2083 mmol, 1.75 equiv),2-phenylimidazole (0.1191 mmol, 1.0 equiv), [RhCl2Cp*]2(0.0029 mmol, 2.5 mol%), and Cu(OAc)2·H2O (0.1338mmol, 1.5 equiv) were weighed in a Schlenk tube anddegassed for 10 min. Anhydrous MeCN (2 mL) was added,and the reaction mixture was purged with argon and allowedto stir at 80 C for 12 h. The solvent was evaporated invacuo, and the residue was purified with columnchromatography (silica gel, 100-200 mesh) using anEtOAc-hexane mixture. Mono- and biscyclopentenylfunctionalizedaza heteroaromatics were obtained in 48%and 39% yields, respectively.

Statistics shows that 4-Methyl-2-phenyl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 827-43-0.

Reference:
Article; Prakash, Praveen; Aparna; Jijy; Santhini; Varughese, Sunil; Radhakrishnan; Synlett; vol. 25; 2; (2014); p. 275 – 279;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding some certain compound to certain chemical reactions, such as: 827-43-0, name is 4-Methyl-2-phenyl-1H-imidazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 827-43-0. 827-43-0

To a solution of 4-methyl-2-phenylimidazole (111, 15.8 g) in dimethylformamide (100 ml) is added sodium hydride. (4.4 g, 60% in mineral oil) in small portions. After the addition is complete, the mixture was stirred for an additional 20 min and treated with 1-iodobutane (18.8 g). The reaction is fitted with a reflux condensor and heated at 100 C. for 12 h. The cooled reaction mixture is partitioned between water (300 ml) and diethyl ether (300 ml). The organic layer is washed with water (3¡Á200 ml), dried (Na2SO4) and concentrated to provide 20.5 g of N-butylimidazoles. Analysis by 1H-NMR and GC-MS revealed mixture of 1-butyl-2-phenyl-4-methylimidazole (112) and 1-butyl-2-phenyl-5-methylimidazole in a ratio of 11.5/1. The mixture was carried on to the next step without purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-Methyl-2-phenyl-1H-imidazole.

Reference:
Patent; Neurogen Corporation; US6723743; (2004); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem