Category: 822-55-9

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a document, author is Menegola, E, introduce the new discover, Formula: C4H6N2O.

Dysmorphogenic effects of some fungicides derived from the imidazole on rat embryos cultured in vitro

Like triazole-derivatives, imidazole-derivatives exert their antifungal and toxicological properties by inhibiting P450 enzymes (Cyps). At the embryonic level, Cyp enzymes are involved also in the catabolism of the retinoic acid. Specific effects of triazole-derivatives have been reported on developing rodent embryos, and were correlated to an imbalance of the retinoid homeostasis. The aim of this work was to investigate if imidazole-derivatives are able to induce specific malformations similar to those observed after triazole-derivative exposure. Post implantation rat embryos were exposed in vitro to 1000 mu M Imidazole and to 5-100 mu M of the imidazole-derivatives Ketoconazole and Enilconazole. After 48 h in culture, the embryos exposed to the imidazole-derivatives showed specific malformations, quite similar to those observed after triazole-derivative exposure. The common dysmorphogenic effects of the azole-derivatives of the two classes could be due to the inhibition of retinoid catabolism. From this point of view, the contemporaneous exposure to these substances or their therapeutic use could be considered as potentially dangerous for human conceptuses. (c) 2005 Elsevier Inc. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 822-55-9 is helpful to your research. Formula: C4H6N2O.

Reference of 822-55-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a article, author is Petrov, Ognyan, introduce new discover of the category.

New Imidazole Derivatives of 2(3H)-Benzazolones as Potential Antifungal Agents

A series of new imidazole derivatives containing 2(3H)-benzoxazolone or 2(3H)-benzothiazolone ring were synthesized as analogues of the antifungal drug bifonazole. All compounds were tested in vitro against Candida albicans, Candida parapsilosis, and Candida krusli.

Reference of 822-55-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 822-55-9 is helpful to your research.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Fang, Zhangjian, once mentioned the application of 822-55-9, Name is 4-(Hydroxymethyl)imidazole, molecular formula is C4H6N2O, molecular weight is 98.1, MDL number is MFCD00266718, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Category: imidazoles-derivatives.

A novel polymerizable imidazole derivative for blue light-emitting material

A novel imidazole derivative, 2-(4-(2,5-dibutoxy-4-vinyistyryl)phenyl)-4,5-diphenyl-1H-imidazole) (VPDPI), as optoclectronic material was designed and synthesized by heck coupling reaction. The structure, thermal analysis and photoluminescence (PL) properties were investigated. The results indicate that the organic compound has good PL property. The emission peak of VPDPI is in the blue regions (465 tun), and the luminescence quantum yield is 0.61 in ethanol, which show that the compound emits blue light and is a desirable blue-emitting photoluminescence material. Also the organic compound shows better thermal stability due to the molecular structure introduced by imidazole heterocyle. The compound can be polymerized for the design of novel and efficient organic optoelectronic materials. (C) 2007 Elsevier B.V. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 822-55-9, Category: imidazoles-derivatives.

In an article, author is Takfaoui, Abdelilah, once mentioned the application of 822-55-9, Name is 4-(Hydroxymethyl)imidazole, molecular formula is C4H6N2O, molecular weight is 98.1, MDL number is MFCD00266718, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Quality Control of 4-(Hydroxymethyl)imidazole.

One pot Pd(OAc)(2)-catalysed 2,5-diarylation of imidazoles derivatives

The regioselective 2- or 5-arylation of imidazole derivatives with aryl halides using palladium catalysts has been described in recent years; whereas the arylation at both C2 and C5 carbons of imidazoles in high yields has not been performed. We found conditions allowing the access to these 2,5-diarylimidazoles via a one pot reaction. The choice of the base was found to be crucial to obtain these products in high yields. Using CsOAc as the base, DMA as the solvent and only 2 mol % of the phosphine-free Pd(OAc)(2) the catalyst, the target 2,5-diarylated imidazoles were obtained in moderate to good yields with a wide variety of aryl bromides. Substituents such as fluoro, trifluoromethyl, formyl, acetyl, propionyl, ester, nitro or nitrile on the aryl bromide were tolerated. Sterically congested aryl bromides or heteroaryl bromides can also be employed. Surprisingly the nature of the substituent at position 1 on the imidazole derivative exhibits a huge influence on the reaction. (C) 2014 Elsevier Ltd. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 822-55-9, Quality Control of 4-(Hydroxymethyl)imidazole.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, molecular formula is C4H6N2O, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Vlaicu, Ioana Dorina, once mentioned the new application about 822-55-9, Name: 4-(Hydroxymethyl)imidazole.

X-ray Crystal Structure, Geometric Isomerism, and Antimicrobial Activity of New Copper(II) Carboxylate Complexes with Imidazole Derivatives

Five new copper(II) acrylate complexes (acr is the acrylate anion: C3H3O2) with imidazole derivatives (2-methylimidazole/2-MeIm, 5-methylimidazole/5-MeIm, 2-ethylimidazole/2-EtIm) of type: cis-[Cu(2-RIm)(2)(acr)(2)]xH(2)O ((1): R = -CH3, x = 2; (4): R = -CH2-CH3, x = 0), trans-[Cu(2-RIm)(2)(acr)(2)] ((2): R = -CH3; (5): R = -CH2-CH3) and trans-[Cu(5-RIm)(2)(acr)(2)] ((3): R = -CH3) have been prepared and characterized by elemental analysis, Fourier Transform Infrared spectrometry (FTIR), Electron Paramagnetic Resonance (EPR), electronic reflectance spectroscopy, scanning electron microscopy, and mass spectrometry. The single crystal X-ray diffraction study of complexes (2) and (5) reveals that the copper(II) ion is located on an inversion center and show elongated octahedral geometry completed by two coplanar bidentate acrylates and two unidentate imidazole derivatives displayed in trans positions. For complex (4) the single crystal X-ray diffraction shows that the copper(II) ion is in a distorted octahedral environment which can be easily confused with a trigonal prism completed by two bidentate acrylates and two unidentate imidazole derivatives displayed in cis positions. These results indicate the fact that complexes (4) and (5) are the geometric isomers of the same compound bis(acrylate)-bis(2-ethylimidazole)-copper(II). Complexes (1) and (2), as well as (4) and (5), were produced simultaneously in the reaction of the corresponding copper(II) acrylate with imidazole derivatives in methanol solution. Furthermore, in order to be able to formulate potential applications of the obtained compounds, our next goal was to investigate the in vitro antimicrobial activity of the synthesized complexes against Gram-positive and Gram-negative bacteria, as well as fungal strains, of both clinical and ecological importance (biodeterioration of historical buildings). The trans isomers (2) and (5), followed by (4) have shown the broadest range of antimicrobial activity. In case of (1) and (2) isomers, the trans isomer (2) was significantly more active than cis (1), while the cis isomer (4) proved to be more active than trans (5). Taken together, the biological evaluation results indicate that the trans (2) was the most active complex, demonstrating its potential for the development of novel antimicrobial agents, with potential applications in the biomedical and restoration of architectural monuments fields.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 822-55-9. The above is the message from the blog manager. Name: 4-(Hydroxymethyl)imidazole.

Electric Literature of 822-55-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a article, author is Ghasemi, Behzad, introduce new discover of the category.

Evaluation of anti-bacterial effects of some novel thiazole and imidazole derivatives against some pathogenic bacteria

Background and Objectives: Bacterial resistance to antibiotics has motivated the researchers to evaluate the novel anti-bacterial compounds such as some thiazole and imidazole derivatives. Thereby, in this work, we investigated the anti-bacterial effects of one new thiazole and two new imidazole derivatives on Bacillus cereus, Listeria monocytogenes, Escherichia coli, Salmonella typhimurium, Proteus mirabilis and Shigella dysenteriae. Materials and Methods: The thiazole and imidazole derivatives were dissolved in DMSO. The disk diffusion method was utilized to measure the growth inhibition zone diameter values, and the broth micro-dilution method was applied to determine the minimum inhibitory concentration (MIC) values. Results: The synthesized imidazole derivatives lacked any inhibitory effect against the tested bacteria. On the other hand, although the synthesized thiazole derivative showed no inhibitory effect against Bacillus cereus, Salmonella typhimurium, and Escherichia coli, it inhibited the growth of Proteus mirabilis, Shigella dysenteriae, and Listeria monocytogenes with the MIC values of 1000, 125, and 1000 mu g/ml, respectively, and the growth inhibition zone diameter values of 9.3 +/- 0.1, 15.6 +/- 0.2, and 8.1 +/- 0.0 mm, respectively. Conclusion: The anti-bacterial effect of the synthesized thiazole derivative on Shigella dysenteriae, Proteus mirabilis and Listeria monocytogenes was proven. However, its inhibition effect against Shigella dysenteriae was more than that against the others. Many in-vitro and in-vivo experiments are required to evaluate the effects of this compound on the bacteria and the human body.

Electric Literature of 822-55-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 822-55-9.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: C4H6N2O, 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a document, author is Ek, F, introduce the new discover.

Synthesis of fused tetrazole- and imidazole derivatives via iodocyclization

The possibility to prepare fused tetrazole- and imidazole derivatives by iodocyclization in moderate to excellent yields is demonstrated. In some examples the cyclizations were not following Baldwin’s rules entirely, i.e. exo-selectivity. Nucleophilic substitution of the formed iodides gave different results depending on the hardness of the nucleophile. Thus, elimination of the iodide could be a problem but a substitution reaction with ethyl potassium xanthate and a radical reaction using acrylonitrile were tolerated. In addition, we showed that it is possible to selectively use three iodo substituents individually in one of the fused imidazole derivatives. (C) 2003 Elsevier Ltd. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 822-55-9. Formula: C4H6N2O.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Category: imidazoles-derivatives822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a article, author is Chermahini, Alireza Najafi, introduce new discover of the category.

Theoretical studies on the reactivity of mono-substituted imidazole ligands

The global and local quantum chemical reactivity descriptors of a series of imidazole derivatives substituted at 2, 4, and 5 positions with different groups including electron-donating and electron-withdrawing substituents have been calculated using the B3LYP/6-311++G(d,p) and MP2/6-311++G(d,p) methods. The substituents have been selected to cover a wide range of electronic effects. Considering the calculated Fukui functions, both imidazole derivatives and their anions are found to be suitable nucleophilic sites in the gas phase. For the most substituents it was observed that the calculated Fukui function values at the N-site are small in case of electron-releasing substituents indicating a preferred N-site for hard reaction. In contrast, large values in case of electron-attracting groups indicate a preferred N-site for soft reaction. These two local descriptors predicted the reactivity of the electron-rich imidazole sequence to be 2-substituted imidazoles > 5-substituted imidazoles > 4-substituted imidazole where reactivity toward electrophilic attack at a pyridine nitrogen atom is enhanced by electron donor substituents elsewhere in the molecule, due to resonance effect.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 822-55-9. Category: imidazoles-derivatives.

Reference of 822-55-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a article, author is Le Borgne, Marc, introduce new discover of the category.

Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(alpha-azolylbenzyl)-1H-indoles as selective aromatase inhibitors

This present study identifies a number of azolyl-substituted indoles as potent inhibitors of aromatase. In the sub-series of 3-(azolylmethyl)-1H-indoles, four imidazole derivatives and their triazole analogues were tested. Imidazole derivatives 11 and 14 in which the benzyl moiety was substituted by 2-chloro and 4-cyano groups, respectively, were the most active, with IC50 values ranging between 0.054 and 0.050 mu M. In the other sub-series, eight 3-(alpha-azolylbenzyl)-1H-indoles were prepared and tested. Compound 30, the N-ethyl imidazole derivative, proved to be an aromatase inhibitor, showing an IC50 value of 0.052 mu M. All target compounds were further evaluated against 17 alpha-hydroxylase/C17,20-lyase to determine their selectivity profile.

Reference of 822-55-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 822-55-9.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a document, author is Zhang, Qiu-Gen, introduce the new discover, Formula: C4H6N2O.

One-Pot Synthesis of Imidazole Derivatives Under Solvent-Free Condition

A convenient and environment-friendly solvent-free procedure has been developed for one-pot synthesis of imidazole derivatives. On comparing tie new method with the classical reaction condition, this new synthetic method shows many advantages such as high yields, easy set-up and mild reaction conditions. This method opens a new way for synthesizing highly efficient imidazole derivatives for green chemistry applications.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 822-55-9 is helpful to your research. Formula: C4H6N2O.