Electric Literature of 81246-34-6, These common heterocyclic compound, 81246-34-6, name is 5-Nitro-1H-imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a soln. of BB-11 (1 eq) in anh. DMF (9 mL/mmol) was added protionwise NaH (1.1 eq, as a 60% dispersion in mineral oil) at 0C. The rxn mixture was stirred for 10 min at 0C and SEM-CI (1.4 eq) was added dropwise. It was allowed to reach RT, stirred for a given time (see Table 4) at RT and partitioned between EtOAc and water. The org. phase was washed with brine, dried over MgSCh and concentrated in vacuo. The crude was purified by CC using Hept/EtOAc.
The synthetic route of 81246-34-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (266 pag.)WO2019/137927; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem