Adding a certain compound to certain chemical reactions, such as: 791595-74-9, name is 5-Bromo-1H-benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 791595-74-9, Recommanded Product: 791595-74-9
The corresponding HCl salt of 11 was prepared for biological testing by dissolving 5-bromo-2-aminobenzimidazole (11, 100 mg, 0.47 mmol, 1.0 eq.) in 1,4-dioxane (5 mL) and adding 4.0 M HCl in 1,4-dioxane (589 muL, 2.36 mmol, 5.0 eq.) The resulting precipitate was filtered and dried in vacuo at 50 C. to yield a red crystalline solid. [0219] 1H NMR (300 MHz, DMSO-d6) delta 7.32 (dd, 1H, J=8.4, 0.6 Hz), 7.36 (dd, 1H, J=8.4, 1.7 Hz), 7.55 (dd, 1H, J=1.7, 0.6 Hz), 8.72 (s, 2H), 12.77 (bs, 2H); 13C NMR (75 MHz, DMSO-d6) delta 113.1, 114.1, 114.5, 125.6, 129.1, 131.2, 150.9; ESI-MS: calculated m/z [M+H]+ 211.9818, observed m/z 211.9811.
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Reference:
Patent; BLACKWELL, Helen; Frei, Reto; Breitbach, Anthony; Lynn, David M.; Broderick, Adam H.; US2013/136782; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem