Category: 7757-21-3

Related Products of 7757-21-3, These common heterocyclic compound, 7757-21-3, name is (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a single neck flask equipped with a condenser and under nitrogen atmosphere was charged 2-CHLORO-3-NITROPYRIDINE (25g, 0. 158 MOLE), Aminomethylbenzimidazole hydrochloride (36. 5g, 0.166 mole) and 200 ml of Ethanol. To this slurry was charged diisopropylethyl amine (137 ml, 0.790 mole) and heated to 65 degrees celcius for 1 hour. Tlc in 5% methanol/ Methylene Chloride (product Rf; 0.5). The reaction was concentrated under vacuo to 100 ml and then cool in an ice bath. Filtered solid and washed cake with minimal amount of Methyl ethyl Ketone to give (LH-BENZOIMIDAZOL-2-YLMETHYL)- (3-NITRO-PYRIDIN-2-YL)-AMINE, a canary Yellow solid (wt= 15.76 g)

Statistics shows that (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride is playing an increasingly important role. we look forward to future research findings about 7757-21-3.

Reference:
Patent; TRIMERIS, INC.; WO2004/43913; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 7757-21-3, name is (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7757-21-3, Computed Properties of C8H10ClN3

In a 100 mL three-necked flask, NaOH (15 g, 0.38 mol) and 15 mL of water were added, mechanically stirred, and after clearing, III-1 (2.63 g, 14.32 mmol) was added.Tetrabutylammonium bromide (185 mg, 0.57 mmol) was stirred at 25 C for 1 hour, and a solution of 1,2-dibromoethane (5.38 g, 28.64 mmol) dissolved in 50 mL of DMF was added dropwise.After the completion of the dropwise addition, the reaction was carried out at 25 C for 4 hours, and filtered by suction.Inorganic salt, concentrated under reduced pressure to give a white solid.Column chromatography (dichloromethane:methanol:aqueous ammonia = 50:1: 0.05 to 40:1:0.05) was purified to afford product (IV-1) 1.25 g, yield 50.4%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; China Pharmaceutical University; Zhu Qihua; Xu Yungen; Wang Junwei; Li Hui; Zhang Guangxia; Ge Yiran; Guan Zhe; (15 pag.)CN109251204; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7757-21-3, name is (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, A new synthetic method of this compound is introduced below., Recommanded Product: 7757-21-3

A solution of 4-bromo-2-iluoropyridine (17.6 mg, 0.1 mmol), (IH- benzo[d]imidazol-2~yl)methanamine HCl salt (2.6.4 mg, 0.12 mmol), cesium carbonate (0.25 mmol) in DMF (1.0 mL) was microwave irradiated at 90 C for lOmin. The solvent wras then removed under vacuum. The residue was dissolved in EtOAc (25 mL), filtered. The organic layer was washed with brine (25 mL), dried and concentrated under vacuum. Purification by chromatography afforded the N-((l H-benzo[d]imidazol-2-yl)methyl)-4-bromopyridin-2- amine.

The synthetic route of 7757-21-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF WASHINGTON; BUCKNER, Frederick, S.; ALVAREZ, Ximena, Barros; FAN, Erkang; GILLESPIE, John, Robert; HOL, Wilhelmus, G.J.; HUANG, Wenlin; KOH, Cho, Yeow; RANADE, Ranae, M.; SHIBATA, Sayaka; VERLINDE, Christophe, L.M.; ZHANG, Zhongsheng; (249 pag.)WO2016/29146; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 7757-21-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7757-21-3 name is (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2,4-Dichloro-benzylamine (47.3mg 0.269mmol) and 3,4-diraethoxy-3- cyiclobutene-l,2-dione (38.2mg, 0.269mmol) were combined in MeOH (2 ml) and water 104 (2ml) and stirred for 2h. C-(lH-benzoimidazol-2-yl)-methylamine HCI (59.4 mg, 0.269mmol) and sat. aHC( (lml) was added in situ. The mixture was stirred at room temperature overnight. After the mixture was extracted with ethyl acetate, washed with brine, concentrated under vacuum and purified via flash column chromatography to yield 3- [(lH-Benzoiniidazol-2-ylmemyl)-amino]-4-(2,4-dicUoro-benzylam dione(1769). LC/MS: (ESI) (M l i s 402.5.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITY OF WASHINGTON; BUCKNER, Frederick, S.; ALVAREZ, Ximena, Barros; FAN, Erkang; GILLESPIE, John, Robert; HOL, Wilhelmus, G.J.; HUANG, Wenlin; KOH, Cho, Yeow; RANADE, Ranae, M.; SHIBATA, Sayaka; VERLINDE, Christophe, L.M.; ZHANG, Zhongsheng; (249 pag.)WO2016/29146; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem