Related Products of 772311-98-5,Some common heterocyclic compound, 772311-98-5, name is 4-((2-Methyl-1H-imidazol-1-yl)methyl)aniline, molecular formula is C11H13N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A slurry of N,lambda^-bis(fer?-butoxycarbonyl)-lH-pyrazole-l-carboxamidine (5.0 g, 16.1 mmol) and 4-(2-methylimidazol-l-ylmethyl)phenylamine (3.0 g, 16.1 mmol) in DMF (11 rnL) was stirred for 64 h. The resulting clear solution was poured into 100 rnL water and extracted with DCM (2×200 rnL) and ethyl acetate (1×100 rnL). The organic layers were combined and washed with brine (50 rnL), dried (Na2SO4), and concentrated in vacuo. The residual material was partially purified by silica gel column chromatography (0-20% MeOH in DCM with 0.05% ammonium hydroxide) to afford the title compound as a slightly impure yellow oil (6.6g, 95%)[0231] 1H NMR (500 MHz, DMSO-J6) delta 1.45 (br s, 18H), 2.23 (s, 3H), 5.10 (s, 2H), 6.75 (d, J = 0.8 Hz, IH), 7.08-7.16 (m, 3H), 7.52 (d, J = 8.4 Hz, 2H), 9.98 (s, IH), 11.39 (s, IH) MS (ES+): m/z 430 (M+H)+
The synthetic route of 772311-98-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TARGEGEN INC.; WO2009/49028; (2009); A1;,
Imidazole – Wikipedia,
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