Category: 7720-39-0

In 2018,Trang, Tran Thi Thu; Dieltjens, Lise; Hooyberghs, Geert; Waldrant, Kai; Ermolat’ev, Denis S.; Van der Eycken, Erik V.; Steenackers, Hans P. L. published 《Enhancing the anti-biofilm activity of 5-aryl-2-aminoimidazoles through nature inspired dimerisation》.Bioorganic & Medicinal Chemistry published the findings.Computed Properties of C3H5N3 The information in the text is summarized as follows:

The increased tolerance of biofilms against disinfectants and antibiotics has stimulated research into new methods of biofilm prevention and eradication. In our previous work, we have identified the 5-aryl-2-aminoimidazole core as a scaffold that demonstrates preventive activity against biofilm formation of a broad range of bacterial and fungal species. Inspired by the dimeric nature of natural 2-aminoimidazoles of the oroidin family, we investigated the potential of dimers of our decorated 5-aryl-2-aminoimidazoles as biofilm inhibitors. A synthetic approach towards 2-aminoimidazole dimers linked by an alkyl chain was developed and a total of 48 dimers were synthesized. The linkers were introduced at two different positions, the N1-position or the N2-position, and the linker length and the substitution of the 5-Ph ring (H, F, Cl, Br) were varied. Although, no clear correlation between linker length and biofilm inhibition was observed, a strong increase in anti-biofilm activity for almost all N1,N1′-linked dimers was obtained, compared to the resp. monomers against Salmonella Typhimurium, Escherichia coli and Staphylococcus aureus. The N2,N2′-linked dimers, having a H- or F-substitution, were also found to show a strong increase in anti-biofilm activity compared to the resp. monomers against these three bacterial species and against Pseudomonas aeruginosa. In addition, the obtained growth measurements suggest a broad concentration range with specific biofilm inhibition and no effect on the planktonic growth against Salmonella Typhimurium and Pseudomonas aeruginosa. In the experimental materials used by the author, we found 1H-Imidazol-2-amine(cas: 7720-39-0Computed Properties of C3H5N3)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Computed Properties of C3H5N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Synthesis of novel galeterone derivatives and evaluation of their in vitro activity against prostate cancer cell lines》 were Jorda, Radek; Reznickova, Eva; Kielczewska, Urszula; Maj, Jadwiga; Morzycki, Jacek W.; Siergiejczyk, Leszek; Bazgier, Vaclav; Berka, Karel; Rarova, Lucie; Wojtkielewicz, Agnieszka. And the article was published in European Journal of Medicinal Chemistry in 2019. HPLC of Formula: 7720-39-0 The author mentioned the following in the article:

Prostate cancer is one of the main causes of male cancer-related deaths worldwide and the suppression of androgen receptor signalling is established as an effective strategy for the treatment. A series of galeterone analogs including several steroid-fused azacycles, as well as 17-(benzimidazol-1-ylimino), 16α-(benzimidazol-2-ylamino), and 16α-(benzothiazol-2-ylamino) steroid derivatives, were synthesized and tested against prostate cancer cell lines. Candidate compound I was shown to reduce AR-regulated transcription in a dose-dependent manner in nanomolar ranges and suppress expression of AR-regulated proteins Nkx3.1 and PSA in 22Rv1-ARE14 and VCaP cancer cell lines. Flexible docking study revealed similar position of I within AR binding site in comparison of galeterone even with stronger binding energy.1H-Imidazol-2-amine(cas: 7720-39-0HPLC of Formula: 7720-39-0) was used in this study.

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.HPLC of Formula: 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 1H-Imidazol-2-amineIn 2021 ,《Synthesis and molecular docking of some new 3,5-bis-(diazepine, pyrazolopyrimidine, pyrimidine, and pyrazole) pyridine derivatives and their in vitro and in vivo biological evaluation as potential antitumor agents》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Soliman, Nanees N.; Tag, Yasmin M.; Bayoumy, Nesma M.. The article conveys some information:

Dihydropyridine-containing bisenaminone I was used to synthesize new heterocyclic compounds containing nitrogen moieties, such as II (R = H, Me, Ph, H2N, 6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl) by reaction with different bifunctional reagents. Moreover, the new compounds were screened in vitro as antitumor agents for Ehrlich ascites at different concentrations The results showed that selected compounds such as II (R = H) had good activity. In addition the mol. docking of these mentioned compounds was studied using vascular endothelial growth factor receptor. In addition to this study using 1H-Imidazol-2-amine, there are many other studies that have used 1H-Imidazol-2-amine(cas: 7720-39-0Reference of 1H-Imidazol-2-amine) was used in this study.

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Reference of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2018,Cheng, Huanbo; Huang, Haihong; Liu, Zhifeng; Zhang, Jie published 《Reaction Kinetics of CFRP Degradation in Supercritical Fluids》.Journal of Polymers and the Environment published the findings.Electric Literature of C3H5N3 The information in the text is summarized as follows:

The reaction kinetics models of carbon fiber-reinforced plastic (CFRP) degradation in supercritical fluids were established by analyzing the chain scission reaction of a cross-linked network in CFRP. The effect of reaction time and temperature on the residual resin content from the recycled carbon fiber was investigated. The reaction order of CFRP degradation was estimated, and the reaction rate constant was calculated at different reaction temperatures Reaction kinetics equations of CFRP degradation in different supercritical fluids were also proposed. Results indicated that CFRP degradation was mainly due to the scission of the C-C, C-O, and -O- bonds in the linear chain segment and of the C-N bond in the cross-linked segment of an epoxy resin cure system. The reaction order was 2 or 2.5. The monofilament tensile strength of recycled carbon fiber in supercritical n-butanol and n-propanol, which had higher degradation reaction rates, decreased by about 2% compared with that of the original carbon fiber. In the experiment, the researchers used 1H-Imidazol-2-amine(cas: 7720-39-0Electric Literature of C3H5N3)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C3H5N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Raghu, M. S.; Pradeep Kumar, C. B.; Yogesh Kumar, K.; Prashanth, M. K.; Alshahrani, Mohammad Y.; Ahmad, Irfan; Jain, Ranjana published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design, synthesis and molecular docking studies of imidazole and benzimidazole linked ethionamide derivatives as inhibitors of InhA and antituberculosis agents》.Related Products of 7720-39-0 The author mentioned the following in the article:

To explore effective antituberculosis agents, a new class of imidazoles and benzimidazoles linked ethionamide analogs I [R = 1H-imidazol-2-yl, 1-methyl-1H-imidazol-2-yl, 1H-1,3-benzodiazol-2-yl, etc.] were designed and synthesized. The elemental anal., 1H NMR, 13C NMR and mass spectral data were used to characterize all of the novel analogs I. In vitro activity against Mycobacterium tuberculosis (Mtb) H37Rv was assessed for all of the target compounds I. The hydroxy and nitrile moieties on the imidazole ring, as well as the hydroxy and methoxy groups on the benzimidazole ring connected to the ethionamide side chain, were shown to be advantageous. In our cell viability experiment against the Vero cell line, all of the compounds I were non-cytotoxic even at 100μM. To confirm the powerful analogs target identification, their in vitro inhibitory action was investigated on an M. tuberculosis InhA over-expressing (Mtb InhA-OE) strain, which yielded MICs nearly twice those of the Mtb H37Rv strain. Furthermore, the results of mol. docking confirmed the exptl. findings. Addnl., the mols. were evaluated in silico for ADMET and drug similarity features. The exptl. observation enables the newly generated ethionamide derivatives to be attractive candidates for the creation of newer and better anti-TB agents. In the experimental materials used by the author, we found 1H-Imidazol-2-amine(cas: 7720-39-0Related Products of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Related Products of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2017,Abdellattif, Magda H.; Eissa, A. M. F.; Mohamed, H. M. published 《Synthesis of anionic surface active agents containing heterocyclic moiety from long chain fatty alcohols》.Journal of Advances in Chemistry published the findings.Safety of 1H-Imidazol-2-amine The information in the text is summarized as follows:

A series of novel groups of anionic surface active agent were synthesized. Synthesis of these surfactants via the reaction of long chain fatty alcs. (octyl, decyl and dodecyl) with maleic anhydride to give monoester. The monoester chloride reacted with amino derivatives of heterocyclic rings followed by addition of NaHSO3. The surface tension, interfacial tension; Kraft point, emulsifying and wetting power were evaluated. Stability to hydrolysis, biodegradability and biol. activities were measured. A comparison studies between the chem. structures and the results were done. After reading the article, we found that the author used 1H-Imidazol-2-amine(cas: 7720-39-0Safety of 1H-Imidazol-2-amine)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Safety of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2017,Draughn, G. Logan; Allen, C. Leigh; Routh, Patricia A.; Stone, Maria R.; Kirker, Kelly R.; Boegli, Laura; Schuchman, Ryan M.; Linder, Keith E.; Baynes, Ronald E.; James, Garth; Melander, Christian; Pollard, Angela; Cavanagh, John published 《Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections》.Drug Design, Development and Therapy published the findings.Quality Control of 1H-Imidazol-2-amine The information in the text is summarized as follows:

2-Aminoimidazole (2-AI)-based compounds have been shown to efficiently disrupt biofilm formation, disperse existing biofilms, and resensitize numerous multidrug-resistant bacteria to antibiotics. Using Pseudomonas aeruginosa and Staphylococcus aureus, we provide initial pharmacol. studies regarding the application of a 2-AI as a topical adjuvant for persistent dermal infections. In vitro assays indicated that the 2-AI H10 is nonbactericidal, resensitizes bacteria to antibiotics, does not harm the integument, and promotes wound healing. Furthermore, in vivo application of H10 on swine skin caused no gross abnormalities or immune reactions. Taken together, these results indicate that H10 represents a promising lead dermal adjuvant compound The experimental process involved the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Quality Control of 1H-Imidazol-2-amine)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Quality Control of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Design, synthesis and nematicidal activitives of trifluorobutene amide derivatives against Meloidogyne incognita》 was written by Yang, Haiping; Zhang, Ruifeng; Li, Zhong; Maienfisch, Peter; Xu, Xiaoyong. SDS of cas: 7720-39-0This research focused ontrifluorobutene amide derivative synthesis treatment nematode nematicide; Amide; In vitro; In vivo; Nematicidal activity; Trifluorobutene. The article conveys some information:

Plant parasitic nematodes have always been a pressing problem in the field of plant protection. Well-established chem. nematicides, especially organophosphorus and carbamates are the most used products for nematode control worldwide. Due to long-term overuse, they have developed serious resistance and new innovative solutions are urgently required. In this study, thirty-one novel trifluorobutene amide derivatives were designed and synthesized, and their nematicidal activities were determined Three different synthetic methods have been developed for the final amidation reaction enabling the successfully syntheses of the target compounds independently from the nucleophilicities of the substrate amino group. Most target compounds showed good nematicidal activity in our in vitro test. Among all the compounds, compounds I and II exhibited excellent nematicidal activity against Meloidogyne incognita, their LC50 values are 2.02 mg L-1 and 0.76 mg L-1, resp. In particular, compound II has found to be almost as active as the com. nematicide fluensulfone. Furthermore, most compounds gave full control (100% inhibition) of M. incognita at 40 mg L-1 in the in vivo tests in sandy soil, the best compounds were further investigated for in vivo activity in matrix soil. Among the compound tested, compound I showed excellent in vivo nematicidal activity. At a concentration of 5 mg L-1 still 56% inhibition was observed The results of our study indicate that compound I possesses excellent in vitro and in vivo nematicidal activity, and can be considered as promising lead mol. for further modification. In the part of experimental materials, we found many familiar compounds, such as 1H-Imidazol-2-amine(cas: 7720-39-0SDS of cas: 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.SDS of cas: 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C3H5N3In 2017 ,《2-Aminoimidazoles: synthesis by ring transformation reactions》 appeared in Studies in Natural Products Chemistry. The author of the article were Babaev, Eugene V.. The article conveys some information:

A review. Marine sponges belonging to the Calcarea family have been proven to be a source of biol. active alkaloids and their metabolites. Two Calcarea genera, Leucetta and Clathrina, have been found to contain more than 60 examples of imidazole alkaloids during the last 30 years. Since the first discovery of 2-aminoimidazole (2-Al) alkaloids in marine sponges by Kashman’s group in 1987. A number of preclathridine and isonaamine alkaloids, representing a family of 1,4-substituted 2-aminoimidazoles bearing one or two substituted benzyl moieties, have been isolated and synthesized in the last decades (see Scheme 2.1) [2]. Of course, the number of 2-AI is not exhausted by these examples; the series is much broader [3]. Many 2-AI alkaloids have been reported to have cytotoxic, antimicrobial, or antifungal properties [4,5],and this topic was recently well reviewed. In addition to this study using 1H-Imidazol-2-amine, there are many other studies that have used 1H-Imidazol-2-amine(cas: 7720-39-0COA of Formula: C3H5N3) was used in this study.

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C3H5N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Hedges, Jason B.; Ryan, Katherine S.. Category: imidazoles-derivatives. The article was titled 《In vitro reconstitution of the biosynthetic pathway to the nitroimidazole antibiotic azomycin》. The information in the text is summarized as follows:

Nitroimidazoles are one of the most effective ways to treat anaerobic bacterial infections. Synthetic nitroimidazoles are inspired by the structure of azomycin, isolated from Streptomyces eurocidicus in 1953. Despite its foundational role, no biosynthetic gene cluster for azomycin has been found. Guided by bioinformatics, we identified a cryptic biosynthetic gene cluster in Streptomyces cattleya and then carried out in vitro reconstitution to deduce the enzymic steps in the pathway linking L-arginine to azomycin. The gene cluster we discovered is widely distributed among soil-dwelling actinobacteria and proteobacteria, suggesting that azomycin and related nitroimidazoles may play important ecol. roles. Our work sets the stage for development of biocatalytic approaches to generate azomycin and related nitroimidazoles. In the experiment, the researchers used many compounds, for example, 1H-Imidazol-2-amine(cas: 7720-39-0Category: imidazoles-derivatives)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem