Category: 7720-39-0

《Effects of Atractylodes Oil on Inflammatory Response and Serum Metabolites in Adjuvant Arthritis Rats》 was published in Biomedicine & Pharmacotherapy in 2020. These research results belong to Qu, Linghang; Xu, Yiyi; Cao, Guosheng; Xu, Kang; Tu, Jiyuan; Lin, Xiong; Wang, Guangzhong; Li, Shuiqing; Liu, Yanju. Name: 1H-Imidazol-2-amine The article mentions the following:

Atractylodes Rhizoma is one of two principal components in Ermiaosan, a well-known traditional Chinese medicine for the treatment of rheumatoid arthritis (RA). Atractylodes oil (AO) represents a potential alternative treatment for RA. The purpose of this study was to investigate the effect of AO in rats with Adjuvant Arthritis (AA) by exploration of changes in serum metabolites using gas chromatog.-mass spectrometry (GC-MS). Foot thickness and arthritis score, ankle joint pathol. structure, the concentrations of TNF-α, IL-1β, IL-6, IL-17 and the expression of MMPs in ankle joint tissue were measured as indicators of efficacy of treatment using AO. In addition, multivariate statistical anal. was used to identify differential production of metabolites and biomarkers, and to analyze metabolic pathways. The results demonstrate that administration of AO resulted in a good therapeutic effect in the AA rat model, with significantly improved joint swelling, reduced joint score, and inhibition of inflammation, synovial pannus hyperplasia, and bone and cartilage destruction. Furthermore, AO was found to exert its effect against rheumatoid arthritis principally by differentially affecting 11 metabolites and six metabolic pathways, predominantly related to abnormal amino acid metabolism, in addition to energy-related metabolic pathways. This study evaluated the capability of AO to effectively treat AA rats, providing a novel strategy for the treatment of RA.1H-Imidazol-2-amine(cas: 7720-39-0Name: 1H-Imidazol-2-amine) was used in this study.

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthetic enzyme-based nanoparticles act as smart catalyst for glucose responsive release of insulin》 was written by Jana, Baishali A.; Shinde, Ujwala; Wadhwani, Ashish. Product Details of 7720-39-0 And the article was included in Journal of Biotechnology in 2020. The article conveys some information:

This study aimed to assess faster responsiveness of insulin release from this enzyme based nanoparticles which is self-regulated insulin delivery system constructed by loading with insulin, enzyme glucose oxidase into hyaluronic acid and 2-nitroimidazole forming enzyme-based nanoparticles which works in accordance to the blood glucose level. Enzyme-based nanoparticles were prepared by ionic gelation method. Insulin content in nanoparticles kept for stability study was estimated by human insulin enzyme based immunosorbent assay. In in-vitro studies; different concentrations of glucose were taken and the release study of insulin was recorded. This enzyme-based nanoparticles were having average diameter of around 193 nm and stability studies showed that nanoparticles were stable up to 30 days at 4°C. In-vitro studies showed the release of insulin from nanoparticle conjugates which was effectively correlated with the external glucose concentration created where different concentrations of glucose taken thus facilitating the stabilization of blood glucose levels in the hyperglycemia state which was achieved within 10 min. wherein drug release rate remarkably increased in hyperglycemia state and no specific changes or small amount of release was observed in normoglycemia state (100 mg/dL). Preliminary study of this enzyme-based nanoparticles formulation showed excellent rapid responsiveness towards hyperglycemia which might act as potential biomimetic system in triggering release of insulin in sustained manner. The experimental process involved the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Product Details of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Product Details of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product Details of 7720-39-0In 2017 ,《Synthesis, dyeing performance on polyester fiber and antimicrobial studies of some novel pyrazolotriazine and pyrazolyl pyrazolone azo dyes》 appeared in Arabian Journal of Chemistry. The author of the article were Rizk, Hala F.; Ibrahim, Seham A.; El-Borai, Mohammed A.. The article conveys some information:

The 5-amino-4-heterylazo-3-phenyl-1H-pyrazoles (2a-d) were diazotized and coupled with malononitrile to give pyrazoloazo malononitrile which by heating in glacial acetic acid gave novel pyrazolo[5,1-c][1,2,4]triazine dyes (3a-d). Also, some diazopyrazolyl pyrazolone dyes (4a-h) were synthesized by diazotization of 2a-d and coupled with some pyrazolone derivatives The structure of the synthesized dyes was determined by elemental anal. and spectral data. All the synthesized compounds were applied as disperse dyes and their dyeing performance on polyester fabric was studied. The fastness and colorimetric properties were measured. The results revealed that the monoazo dyes have good fastness and good to moderate affinity to polyester fabric than diazo dyes. In addition, the synthesized dyes were screened for their antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa (Gram pos.), Bacillus subtitles, Escherichia coli (Gram neg.) and Candida albicans, Aspergillus niger (Fungi). The results revealed that most of the prepared dyes have high antibacterial activity. In the part of experimental materials, we found many familiar compounds, such as 1H-Imidazol-2-amine(cas: 7720-39-0Product Details of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Product Details of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 7720-39-0In 2021 ,《A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors》 was published in RSC Medicinal Chemistry. The article was written by Weig, Alexander W.; Barlock, Samantha L.; O’Connor, Patrick M.; Marciano, Orry M.; Smith, Richard; Ernst, Robert K.; Melander, Roberta J.; Melander, Christian. The article contains the following contents:

Infections that stem from bacterial biofilms are difficult to eradicate. Within a biofilm state, bacteria are upwards of 1000-fold more resistant to conventional antibiotics, necessitating the development of alternative approaches to treat biofilm-based infections. One such approach is the development of small mol. adjuvants that can inhibit/disrupt bacterial biofilms. When such mols. are paired with conventional antibiotics, these dual treatments present a combination approach to eradicate biofilm-based infections. Previously, we have demonstrated that small mols. containing either a 2-amino pyrimidine (2-AP) or a 2-aminoimidazole (2-AI) heterocycle are potent anti-biofilm agents. Herein, we now report a scaffold hopping strategy to generate new aryl 2-AP analogs that inhibit biofilm formation by methicillin-resistant Staphylococcus aureus (MRSA). These mols. also suppress colistin resistance in colistin resistant Klebsiella pneumoniae, lowering the min. inhibitory concentration (MIC) by 32-fold. The results came from multiple reactions, including the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Related Products of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Quality Control of 1H-Imidazol-2-amineIn 2017 ,《Synthesis and characterization of S(-)1-phenyl-1,2,3,4-tetrahydro isoquinoline acetamide analogues》 was published in Asian Journal of Chemistry. The article was written by Krishna Rao, N.; Surendra Babu, M.; Basaveswara Rao, M. V.; Keshavi, R.; Sundara Rao, N.; Eswara Prasad, N. H.; Murthy, Y. L. N.. The article contains the following contents:

S(-)1-Phenyl-1,2,3,4-tetrahydroisoquinoline acetamide analogs are prepared by sequence of reactions which involve a metal hydride reduction of 3,4-dihydroisoquinoline followed by separation of S-form with mandelic acid (chiral reagent) by resolution The product S(-)1-phenyl-1,2,3,4-tetrahydroisoquinoline is treated with chloroacetyl chloride to obtain tetrahydroisoquinoline acetyl chloride which is further employed to synthesize acetamide derivatives of tetrahydroisoquinoline I [R = Ph, 4-hydroxyphenyl, pyrimidin-2-yl, etc.] using various substituted aryl amines RNH2. The products were characterized by advanced spectroscopic techniques.1H-Imidazol-2-amine(cas: 7720-39-0Quality Control of 1H-Imidazol-2-amine) was used in this study.

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2018,Organic & Biomolecular Chemistry included an article by Wang, Jing; Hu, Xuefeng; Wang, Dongli; Xie, Cao; Lu, Weiyue; Song, Jie; Wang, Ruifeng; Gao, Chunli; Liu, Min. Synthetic Route of C3H5N3. The article was titled 《2-Aminoimidazole facilitates efficient gene delivery in a low molecular weight poly(amidoamine) dendrimer》. The information in the text is summarized as follows:

Functional groups have shown great potential in gene delivery. However, a number of the reported functional groups can only overcome one certain physiol. barrier, resulting in limited transfection efficiencies. Based on the structure-activity relationships of both imidazolyl and guanidyl, we designed a novel multifunctional group, 2-aminoimidazole (AM), for gene delivery. On modifying with the AM group, the transfection efficiency of low mol. weight poly(amidoamine) (G2) was 200 times greater than the parent dendrimer in vitro. In contrast, the transfection efficiency of G2 showed a decreasing trend when it was grafted with imidazole. Assays revealed that the AM group played multiple roles in gene delivery, including condensing DNA into monodisperse nanoparticles of 80-90 nm in diameter, achieving nearly ten times higher cellular-uptake efficacy, and enhancing the abilities of endosome/lysosome escape and nuclear localization. What’s more, AM showed low toxicity. These results demonstrate that the AM group could be a promising tool in non-viral gene delivery. After reading the article, we found that the author used 1H-Imidazol-2-amine(cas: 7720-39-0Synthetic Route of C3H5N3)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Synthetic Route of C3H5N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2018,Minrovic, Bradley M.; Jung, David; Melander, Roberta J.; Melander, Christian published 《New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii》.ACS Infectious Diseases published the findings.Application In Synthesis of 1H-Imidazol-2-amine The information in the text is summarized as follows:

Antibiotic resistance has become increasingly prevalent over the past few decades, and this combined with a dearth in the development of new classes of antibiotics to treat multidrug resistant Gram-neg. infections has led to a significant global health problem and the increased usage of colistin as the last resort antibiotic. Colistin, however, presents dose dependent toxicity in the clinic. One potential approach to combating this problem is the use of an antibiotic adjuvant, a compound that is nontoxic to the bacteria that enhances the potency of colistin and ultimately allows for reducing dosing. Herein, we present a new urea-containing class of 2-aminoimidazole-based adjuvants that potentiates colistin activity against colistin-sensitive Acinetobacter baumannii. Lead compounds enabled 1000-fold reduction in the min. inhibitory concentration of colistin in vitro and showed efficacy in a Galleria mellonella infection model, representing the first step toward validating the potential of employing these adjuvants to lower colistin dosage. After reading the article, we found that the author used 1H-Imidazol-2-amine(cas: 7720-39-0Application In Synthesis of 1H-Imidazol-2-amine)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Application In Synthesis of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2018,Martin, Sara E.; Nguyen, Catherine M.; Basaraba, Randall J.; Melander, Christian published 《Analogue synthesis reveals decoupling of antibiofilm and β-lactam potentiation activities of a lead 2-aminoimidazole adjuvant against Mycobacterium smegmatis》.Chemical Biology & Drug Design published the findings.Product Details of 7720-39-0 The information in the text is summarized as follows:

Biofilm formation is one of the many mechanisms bacteria utilize to survive antibiotic treatment. It has been demonstrated that when Mycobacterium tuberculosis exists in a biofilm in vitro, it expresses phenotypic resistance to antimicrobial drugs. As the in vivo survival of M. tuberculosis following drug treatment is potentially linked to a biofilm-like expression of drug tolerance, it is hypothesized that biofilm dispersion should increase antibiotic susceptibility and reduce the duration of the current antibiotic treatment regimen. Previously, we have identified a 2-aminoimidazole (2-AI) compound capable of dispersing and inhibiting M. tuberculosis and M. smegmatis biofilms in vitro. Addnl., this compound potentiated the activity of carbenicillin against M. tuberculosis and, to a lesser degree, M. smegmatis. Here, we describe a SAR study on this compound evaluating each derivative for biofilm dispersion and β-lactam potentiation capabilities against M. smegmatis. This study identified a compound that improved upon the biofilm dispersion capabilities of the lead compound Interestingly, a different compound was identified with an increased ability to potentiate a subset of β-lactam antibiotics. These compounds indicate that biofilm dispersion and potentiation capabilities may not be associated In the experimental materials used by the author, we found 1H-Imidazol-2-amine(cas: 7720-39-0Product Details of 7720-39-0)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Product Details of 7720-39-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Some studies in sulfadiazine incorporating pyridine, pyrimidine, oxadiazole, and azo moieties endowed with pharmaceutical potency》 was published in Acta Chimica Slovenica in 2020. These research results belong to El-Hadidya, Sherihan A.; Abu-Melhab, Sraa. Computed Properties of C3H5N3 The article mentions the following:

A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material. Compound 1 was reacted with different reagents to give the corresponding sulfadiazines 2-18 and hydrozaones 19a-h which were evaluated for their in vitro cytotoxicity vs. four cancer cell lines. Compounds 3, 5, 19d and 19h were active against the tested cancer cells. The experimental process involved the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Computed Properties of C3H5N3)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Computed Properties of C3H5N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Atkinson, Ariel J.; Armstrong, Mikayla D.; Eskew, John T.; Coronell, Orlando published their research in Journal of Membrane Science in 2021. The article was titled 《Aminoimidazole reduces fouling and improves membrane performance》.Reference of 1H-Imidazol-2-amine The article contains the following contents:

Biofouling is difficult to control and hinders the performance of membranes in all applications but is of particular concern when natural waters are purified. Fouling, via multiple mechanisms (organic-only, biofouling-only, cell-deposition-only, and organic + biofouling), of a com. available membrane (control) and a corresponding membrane coated with an anti-biofouling 2-aminoimidazole (2-AI membrane) was monitored and characterized during the purification of a natural water. Results show that the amount of bacterial cell deposition and organic fouling was not significantly different between control and 2-AI membranes; however, biofilm formation, concurrent or not with other fouling mechanisms, was significantly inhibited (95-98%, p < 0.001) by the 2-AI membrane. The limited biofilm that formed on the 2-AI membrane was weaker (as indicated by the polysaccharide to protein ratio) and thus presumably easier to remove. The conductivity rejection by the 2-AI and control membranes was not significantly different throughout the 75-h experiments, but the rejection of dissolved organic carbon by biofouled (biofouling-only, cell-deposition-only, and organic + biofouling) 2-AI membranes was statistically higher (10-12%, p = 0.003-0.07). When biofouled, the water permeance of the 2-AI membranes decreased significantly less (p < 0.05) over 75 h than that of the control membranes, whether or not other addnl. types of fouling occurred concurrently. Despite the initially lower water permeances of 2-AI membranes (11% lower on average than controls), the 2-AI membranes outperformed the controls (10-11% higher average water permeance) after biofilm formation occurred. Overall, 2-AI membranes fouled less than controls without detriment to water productivity and solute rejection. The experimental process involved the reaction of 1H-Imidazol-2-amine(cas: 7720-39-0Reference of 1H-Imidazol-2-amine)

1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Reference of 1H-Imidazol-2-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem