A direct method for the substitution of imidazo[1,5-a]pyridines at position 5 was written by Blatcher, Philip;Middlemiss, David. And the article was included in Tetrahedron Letters in 1980.Synthetic Route of C10H10N2O2 The following contents are mentioned in the article:
Lithiation of 3-ethylthioimidazo[1,5-a]pyridine (I; R = SEt, R1 = H) (II) occurred at C-5. Quenching of this anion followed by desulfurization gave 5-substituted imidazo[1,5-a]pyridines. E.g. II reacted with BuLi and PhCHO giving 71% I [R = SEt, R1 = CH(OH)Ph] which on treatment with Raney Ni gave 65% I [R = H, R1 = CH(OH)Ph]. This study involved multiple reactions and reactants, such as Ethyl imidazo[1,5-a]pyridine-5-carboxylate (cas: 76292-67-6Synthetic Route of C10H10N2O2).
Ethyl imidazo[1,5-a]pyridine-5-carboxylate (cas: 76292-67-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Synthetic Route of C10H10N2O2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem