Category: 7467-35-8

Shi, Xing-Xing published the artcileFerromagnetic coupling in copper benzimidazole chloride: structural, mass spectrometry, magnetism, and DFT studies, Category: imidazoles-derivatives, the publication is Dalton Transactions (2017), 46(47), 16663-16670, database is CAplus and MEDLINE.

Herein, quasi-square planar Cu^II(Hmbm)Cl₂ (CBC, Hmbm = (1-methyl-1H-benzo[d]imidazol-2-yl)methanol) was arranged in a pseudo orthogonal way to form Cl-bridged chains, and further π···π interactions resulted in distorted hexagonal layers. DFT calculations reveal a bond strength order of Cu-Cl > Cu-O/N ≫ Cu···Cl. ESI-MS data reveal several small fragments from CBC, but oligomeric [Cu^II₂], [Cu^II₃], and [Cu^II₄] for non-zero in-source energies; MS data indicates the occurrence of several chem. processes, viz. splitting of the ligand, oligomerization, and redox reaction of alc. to aldehyde and Cu^II to Cu^I. Gibbs free energies for the fragments were estimated using DFT. The magnetic susceptibility was modeled with the ferromagnetic coupling J(Cu-Cl2a···Cu) = +0.99(30) cm^-1 and J'(π···π) = +0.35(16) cm^-1 and g = 2.38(2). HF-EPR determined the anisotropic g-values, g_x = 2.24, g_y = 2.16, and g_z = 2.09, and a hyperfine constant of A_z = 450 G. DFT calculations from crystal structure data reveal a J(Cu-Cl2a···Cu) of +3.6 at 296 K and +4.1 cm^-1 at 90 K that dominates the magnetic properties, whereas J'(π···π) = 0.04 cm^-1 is negligibly small.

Dalton Transactions published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C8H17Br, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Boulebd, Houssem published the artcileSynthesis and biological evaluation of heterocyclic privileged medicinal structures containing (benz)imidazole unit, HPLC of Formula: 7467-35-8, the publication is Monatshefte fuer Chemie (2016), 147(12), 2209-2220, database is CAplus.

Abstract: New heterocyclic privileged medicinal scaffolds involving 4H-pyran, 1,4-dihydropyridine, quinazoline, and 2-aminochromene bearing a (benz)imidazole unit were prepared in good to excellent yields, and evaluated for their in vitro hepatotoxicity on HepG2 cells and antioxidant activity using DPPH radical-scavenging assay. From these results, 2-amino-4-(1-methyl-1H-imidazol-2-yl)-4H-benzo[h]chromene-3-carbonitrile has been identified as a racemic, readily available imidazole derivative, significantly less hepatotoxic than tacrine at 100 μM concentration One compound was a potent antioxidant agent. The catalytic effect of the 1-methylimidazole unit, in the synthesis of some heterocycle, was also demonstrated. Crystal x-ray structures are reported for six compounds Graphical abstract: [Figure not available: see fulltext.].

Monatshefte fuer Chemie published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, HPLC of Formula: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Aweke, Bamlaku Semagne published the artcileA Bis-(carbone) Pincer Ligand and Its Coordinative Behavior toward Multi-Metallic Configurations, Formula: C9H10N2O, the publication is Angewandte Chemie, International Edition (2022), 61(24), e202201884, database is CAplus and MEDLINE.

Carbones are divalent carbon(0) species that contain two lone pairs of electrons. Herein, authors have prepared the first known stable and isolable free bis-(carbone) pincer framework with a well-defined solid-state structure. This bis-(carbone) ligand is an effective scaffold for forming monometallic (Ni and Pd) and trinuclear heterometallic complexes with Au-Pd-Au, Au-Ni-Au, and Cu-Ni-Cu configurations. Sophisticated quantum-theor. analyses found that the metal-metal interactions are too weak to play a significant role in upholding these multi-metallic configurations; rather, the four lone pairs of electrons within the bis-(carbone) framework are the main contributors to the stability of the complexes.

Angewandte Chemie, International Edition published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Formula: C9H10N2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Ming published the artcileChemical reaction within a compact non-porous crystal containing molecular clusters without the loss of crystallinity, Safety of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Chemical Science (2017), 8(8), 5356-5361, database is CAplus and MEDLINE.

The very rare occurrence of a gas-solid chem. reaction has been found to take place on a mol. within a compact non-porous crystal without destroying its long-range structural order and retaining similar crystal structures when yellow crystals of Fe^II₄(mbm)₄Cl₄(MeOH)₄ were exposed to air to give black [Fe^III₄(mbm)₄Cl₄(OH)₄]·2H₂O. The latter cannot be synthesized directly. The original cluster underwent an exchange of methanol to hydroxide, an oxidation of Fe(II) to Fe(III), a change in stereochem. and hydration while the packing and space-group remained unaltered.

Chemical Science published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C6H6N2O, Safety of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sawlewicz, Jozef published the artcileSynthesis of thiocyanates derived from benzimidazole, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Acta Poloniae Pharmaceutica (1976), 33(4), 429-32, database is CAplus and MEDLINE.

2-(Hydroxymethyl)benzimidazole and ClCH2COCl in anhydrous dioxane yielded the benzimidazole I (R1 = R2 = H), which was treated with KSCN to give II (R1 = R2 = H). Analogously prepared were I and II (R1 and R2 given): H, Me; Me, H; PhCH2, H; PhCH2, Me. Chloroacetylation of the N-substituted benzimidazoles required an excess of ClCH2COCl to be used. The benzimidazoles were bactericidal.

Acta Poloniae Pharmaceutica published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ma, Xiong-Feng published the artcileLigand Effect on the Single-Molecule Magnetism of Tetranuclear Co(II) Cubane, SDS of cas: 7467-35-8, the publication is Inorganic Chemistry (2017), 56(24), 15178-15186, database is CAplus and MEDLINE.

A clear dependence on the ligand has been observed for the magnetic properties of a closely related series of Co(II) cubane structures, viz. [Co₄(mbm or bm)₄(ROH)₄Br₄] (1-MeOH, 1-EtOH, 2-MeOH, and 2-EtOH, where 1 = [Co₄(mbm)₄Br₄], 2 = [Co₄(bm)₄Br₄], bm = (1H-benzo[d]imidazol-2-yl)methanolate. and mbm = 1-Me-bm.). The [Co₄(OR)₄] cubane core consists of an octahedral Co^II center chelated by the alkoxide oxygen and imidazole nitrogen atoms from monoanionic bm or mbm and coordinated by methanol/alc. and bromine. Interestingly, electrospray ionization mass spectrometry (ESI-MS) indicates that 1-MeOH and 2-MeOH are unstable in methanol and transformed to the butterfly [Co₄L₆]²⁺ but that 1-EtOH and 2-EtOH are stable in ethanol. Their magnetic susceptibilities suggest ferromagnetic coupling between the nearest cobalt centers to give a theor. S = 4 × 3/2 ground state with considerable magneto-crystalline behavior. The packing and intermol. interactions appear to influence the geometry of the cubes and thus the anisotropy of cobalt, which leads to different blocking temperatures (T_B). Consequently, the compounds with mbm, 1-MeOH and 1-EtOH, exhibit T_B > 2 K as shown by the relaxation of magnetization in zero applied dc field where the barriers U_eff/k_B are resp. 27 and 21 K and relaxation times are τ₀ = 1.3 × 10^-9 and 9.7 × 10^-9 s. However, the compounds with bm, 2-MeOH and 2-EtOH, remain paramagnetic above 2 K and do not show nonlinear response of the ac susceptibilities. These findings reaffirm the subtle dependence of single-mol. magnetism on coordination geometry and intermol. interaction.

Inorganic Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, SDS of cas: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Ling-Yun published the artcileButterfly and chair clusters using N,O-chelating ligands: A combined crystallographic and mass spectrometric study, Quality Control of 7467-35-8, the publication is Applied Organometallic Chemistry (2020), 34(5), e5533, database is CAplus.

The organic ligand (1-methyl-1H-benzo[d]imidazol-2-yl)methanol (HL¹) was used to react with Cu(ClO₄)₂·6H₂O and triethylamine at 80°C to afford the complex [Cu₄(L¹)₆]·(ClO₄)₂·CH₃CN (1). Every four-coordinated Cu(II) ion is surrounded with NO₃ coordinated environment, and every five-coordinated Cu(II) ion is surrounded with N₂O₃ coordinated environment. Changing the metal salt to Zn(NO₃)₂·6H₂O, and after adding CH₃COONa, afforded the complex [Zn₄(L¹)₄(NO₃)₂(CH₃COO)₂] (2), in which every five-coordinated Zn(II) ion is surrounded with NO₄ coordinated environment. High-resolution electrospray ionization mass spectrometry results revealed that complex 1 broke into the most stable fragment [Cu₂(L¹)₃]⁺, and it also can assemble high nuclear peaks in solution For complex 2, it was found that the complex exhibited different component distribution in solution Not only were there substitutions between coordinated anions, but the high nuclear peaks could also be detected.

Applied Organometallic Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C8H11BO2, Quality Control of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ryabukhin, Dmitry S. published the artcileReactions of 2-carbonyl- and 2-hydroxy(or methoxy)alkyl-substituted benzimidazoles with arenes in the superacid CF3SO3H. NMR and DFT studies of dicationic electrophilic species, SDS of cas: 7467-35-8, the publication is Beilstein Journal of Organic Chemistry (2019), 1962-1973, database is CAplus and MEDLINE.

Reactions of 2-carbonyl- and 2-hydroxy(or methoxy)alkylbenzimidazoles with arenes in the Bronsted superacid TfOH resulted in the formation of the corresponding Friedel-Crafts reaction products, 2-diarylmethyl and 2-arylmethyl-substituted benzimidazoles, in yields up to 90%. The reaction intermediates, protonated species derived from starting benzimidazoles in TfOH, were thoroughly studied by means of NMR and DFT calculations; and plausible reaction mechanisms were discussed.

Beilstein Journal of Organic Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, SDS of cas: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Khristich, B. I. published the artcileFree-radical hydroxymethylation of benzimidazole, SDS of cas: 7467-35-8, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1982), 1679-81, database is CAplus.

Free radical hydroxymethylation of benzimidazoles I (R = Me, PhCH₂, Ph, p-MeOC₆H₄, p-PhC₆H₄, R¹ = R² = H; R = Me, R¹ = NO₂, MeO, R² = H) to give hydroxymethyl derivatives I (R² = CH₂OH) was carried out by refluxing in aqueous MeOH containing concentrated H₂SO₄ and (NH₄)₂S₂O₈ 24 h, or by heating aqueous MeOH containing concentrated H₂SO₄ and (NH₄)₂S₂O₈ in an ampule 7 h at 40-50°, or by refluxing an aqueous MeOH solution containing concentrated H₂SO₄, AgNO₃, and (NH₄)₂S₂O₈ 3 h. Higher yields were obtained via the last method.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, SDS of cas: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sharma, Pankaj published the artcileNew (E)-1-alkyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-ones: Synthesis, in vitro cytotoxicity evaluation and apoptosis inducing studies, Related Products of imidazoles-derivatives, the publication is European Journal of Medicinal Chemistry (2016), 584-600, database is CAplus and MEDLINE.

A new series of (E)-[(benzo[d]imidazol-2-yl)methylene]indolin-2-one derivatives has been synthesized and evaluated for their in vitro cytotoxic activity against a panel of selected human cancer cell lines of prostate (PC-3 and DU-145) and breast (BT-549, MDA-MB-231, MCF-7, 4T1), non-small lung (A549) and gastric (HGC) cancer cells along with normal breast epithelial cells (MCF10A). Among the tested compounds, 8l (I) showed significant cytotoxic activity against MDA-MB-231 and 4T1 cancer cells with IC₅₀ values of 3.26 ± 0.24 μM and 5.96 ± 0.67 μM resp. The compounds 8f (II), 8i (III), 8l (I) and 8o (IV) were also screened on normal human breast epithelial cells (MCF10A) and found to be safer with lesser cytotoxicity. The treatment of MDA-MB-231 cells with 8l led to inhibition of cell migration ability through disruption of F-actin protein assembly. The flow-cytometry anal. reveals that the cells arrested in G0/G1 phase of the cell cycle. Further, the compound 8l induced apoptosis of MDA-MB-231 cells was characterized by different staining techniques such as Acridine Orange/Ethidium Bromide (AO/EB), DAPI, annexin V-FITC/PI, Rhodamine-123 and MitoSOX red assay. Western blot studies demonstrated that the compound 8l treatment led to activation of caspase-3, increased expression of cleaved PARP, increased expression of pro-apoptotic Bax and decreased expression of anti-apoptotic Bcl-2 in MDA-MB-231 cancer cells.

European Journal of Medicinal Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C16H14O6, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem