3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: A class of potent DPP-4 inhibitors was written by Eckhardt, Matthias;Hauel, Norbert;Himmelsbach, Frank;Langkopf, Elke;Nar, Herbert;Mark, Michael;Tadayyon, Moh;Thomas, Leo;Guth, Brian;Lotz, Ralf. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.HPLC of Formula: 74478-96-9 This article mentions the following:
Systematic variations of the xanthine scaffold in close analogs of development compound BI 1356 led to the class of 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones which provided, after substituent screening, a series of highly potent DPP-4 inhibitors. In the experiment, the researchers used many compounds, for example, Ethyl 2,4-dibromo-1H-imidazole-5-carboxylate (cas: 74478-96-9HPLC of Formula: 74478-96-9).
Ethyl 2,4-dibromo-1H-imidazole-5-carboxylate (cas: 74478-96-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.HPLC of Formula: 74478-96-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem