Category: 73590-85-9

On April 25, 2019, Herga, Marko; Gasparic, Ales; Bitenc, Marko; Pohar, Andrej; Likozar, Blaz published an article.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Development, optimization and scale-up of stereo-selective enzymatic Baeyer-Villiger oxidation of pyrmetazole to esomeprazole active ingredient in an industrial-scale slurry reactor. And the article contained the following:

An industrial-scale stereo-selective enzymic oxidation process for the conversion of pyrmetazole to esomeprazole was developed and optimized. Slurry-to-slurry stages are highly demanding synthetic operations due to several deteriorating factors: competing equilibrium, mass transfer limitations and long-term biocatalytic activity. Challenging characteristics of this bio-oxidation included foaming, thickening, continuous dynamic changes in viscosity, mass transport, and biocatalyst inactivation. By screening pH, optimization of reactant loading ratios, and modification of control, crucial production attributes of materials, such as substrate particle size, were controlled and better batch-to-batch stability and scale-up was achieved. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to pyrmetazole stereo selective enzymic baeyer villiger oxidation esomeprazole, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Liu, Hui; Gu, Zheng; Tian, Yuan; Jiang, Guofang published an article in 2015, the title of the article was Chiral metalloporphyrin-catalyzed industrial synthesis of sodium esomeprazole.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

Sodium esomeprazole is a kind of excellent proton pump inhibitor, used as an effective drug for peptic ulcer disease. A new industrialized synthetic technol. of sodium esomeprazole catalyzed by chiral metalloporphyrin was reported. The target product was approved by 1H NMR, MS and polarimetry. The effect of reaction time, reaction temperature, and molar ratio of catalyst and solvent were investigated. The results show that sodium esomeprazole can be obtained with high yield from oxidation by oxygen in the NaOH solution and ufiprazole, synthesized by the addition reaction between 2-chloro-3,5-dimethyl-4-methoxypyridine hydrochloride and 5-methoxy-2-mercaptobenzimidazole in the combination of 20% NaOH and TBAB. Synthesis of esomeprazole sodium used by ufiprazole has the highest yield and enantioselectivity when reaction time is 3.0 h, the solvent is toluene, the reaction temperature is 80掳C and the ratio of omeprazole sulfide and chiral metal porphyrin is 1: (3.7 脳 10-5). The total industrial yield is 60% and the enantioselectivity is 98.9%. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to sodium esomeprazole chiral metalloporphyrin catalytic oxidation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 29, 2012, Zhao, Shan-shan; Lu, Hua; Zhang, Yue-cheng; Zhao, Ji-quan published an article.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Application of D(-)-di-pyridylmethyl tartaric acid amide in the synthesis of esomeprazole through asymmetric oxidation. And the article contained the following:

Two di-pyridylmethyl D (-)-tartaric acid amides 2 and 3 were resp. prepared through the reaction of (-)-di-Et D-tartrate(1) with 2-aminomethyl pyridine and 4-aminomethyl pyridine. The compounds 1, 2 and 3 coordinated with iso-Pr titanate, resp., were used as catalyst in the asym. oxidation of the precursor (Eso-I) of esomeprazole with cumene hydroperoxide (CHP) as oxidant. The results revealed that both the catalytic systems derived from ligand 2 and 3 and iso-Pr titanate showed good catalytic activity and enantioselectivity in the synthesis of esomeprazole. For example, the conversion of Eso-I, the selectivity toward to the esomeprazole and the enantio excess reached 84.7%, 91.8% and 89.0%, resp., when 2 was used as the ligand and the reaction was conducted in toluene under the optimized conditions. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to dipyridylmethyl tartaric acid amide esomeprazole asym oxidation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 20, 2013, Song, Wei-guo; Zhang, Xiang-min; Zhang, Xiao-pan; Xu, Wen-fang published an article.Related Products of 73590-85-9 The title of the article was Synthesis of esomeprazole sodium. And the article contained the following:

Esomeprazole was the first optical isomer proton pump inhibitor, and its sodium salt was applied to the patients who are in need of PPI but not capable of oral dosing. At present, there were three methods to synthesize esomeprazole such as omeprazole racemic resolution, omeprazole sulfide complexes asym. catalytic oxidation and biochem. oxidation However, the omeprazole racemic resolution was limited industrially due to its high cost and low yield. The aim of this study was to propose a modified asym. oxidation method to prepare esomeprazole for industrialized production Compared with the traditional method, this new method had three advantages. Firstly, the (1S, 2S)-(-)-1,2-diaminocyclohexane D-tartrate was used as chiral ligands, which avoided the addition of organic alkali in the traditional route. Secondly, cobalt naphthenate was applied as the catalyst to solve the problem of water-contacting over traditional titanium catalyst. Lastly, sodium peroxide was not only the oxidant to lower the cost of asym. oxidizing the omeprazole sulfide compounds but also the source of sodium for no more addition of other sodium source. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9

The Article related to esomeprazole sodium synthesis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Related Products of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 28, 2009, Hao, Linghua; Li, Wei; Wei, Jinzhao; Chen, Shuai; Wu, Song published an article.COA of Formula: C17H19N3O2S The title of the article was Preparation of two impurities of omeprazole. And the article contained the following:

To perform the quality control of omeprazole, two impurities of omeprazole 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole and 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfonyl]-1H-benzimidazole were prepared via condensation and oxidation from 5-methoxy-2-benzimidazolethiol and 2-chloromethyl-3,5-dimethyl-4-methoxypyridine. Their structures were confirmed by 1HNMR and MS. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).COA of Formula: C17H19N3O2S

The Article related to omeprazole impurity synthesis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.COA of Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 30, 2014, Baddam, Sudhakar Reddy; Neelam, Uday Kumar; Manne, Naga Raju; Adulla, Panasa Reddy; Bandichhor, Rakeshwar published an article.Application of 73590-85-9 The title of the article was Zinc triflate catalyzed synthesis of thioethers. And the article contained the following:

Zinc triflate-catalyzed aralkylation of thiols using various substituted benzylic alcs. was developed for the synthesis of thioether (sulfide) derivatives This procedure presents a greener approach for the synthesis of sulfides. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application of 73590-85-9

The Article related to alc thiol thioetherification zinc triflate catalyst green chem, thioether preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 9, 2009, Sousa, Sara C. A.; Fernandes, Ana C. published an article.Formula: C17H19N3O2S The title of the article was Highly efficient and chemoselective reduction of sulfoxides using the system silane/oxo-rhenium complexes. And the article contained the following:

This work reports a novel method for the reduction of sulfoxides with silanes catalyzed by high valent oxo-rhenium(V) and (VII) complexes. The catalytic system PhSiH3/ReIO2(PPh3)2 (1 mol %) proved to be highly efficient for the reduction of a wide range of sulfoxides in excellent yields under mild conditions. This novel methodol. is also highly chemoselective, tolerating several functional groups such as -CHO, -CO2R, -Cl, -NO2, and double or triple bonds. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Formula: C17H19N3O2S

The Article related to chemoselective reduction sulfoxide silane rhenium catalyst, thio ether preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Dong; Liu, Zhenlin; Wang, Zhentao; Ma, Xinyue; Yu, Peng published an article in 2019, the title of the article was Metal- and base-free regioselective thiolation of the methyl C(sp3)-H bond in 2-picoline N-oxides.Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

A one-pot, two-step synthesis of pyridine-2-ylmethyl thioethers is developed through a TFAA-mediated [3,3]-sigmatropic rearrangement of pyridine N-oxides and TBAB-catalyzed direct conversion of trifluoroacetates into thioethers under metal- and base-free conditions. This methodol. enables thiolation of the unactivated Me C(sp3)-H bond in 2-picolines with thiols. Remarkable features of the method include high regioselectivity, step- and atom-economy, mild conditions, simple operation, wide substrate scope and scalability. Furthermore, the method has been successfully applied to the synthesis of omeprazole sulfide and rabeprazole sulfide without the need for TBAB catalysis. A comprehensive green chem. metrics anal. indicated that this method is much more efficient and greener than the reported synthesis of rabeprazole sulfide. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to aryl pyridylmethyl sulfide preparation, picoline thiophenol regioselective thiolation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Acosta-Guzman, Paola; Mahecha-Mahecha, Camilo; Gamba-Sanchez, Diego published an article in 2020, the title of the article was Electrophilic Chlorine from Chlorosulfonium Salts: A Highly Chemoselective Reduction of Sulfoxides.COA of Formula: C17H19N3O2S And the article contains the following content:

A selective late-stage deoxygenation of sulfoxides based on a novel application of chlorosulfonium salts RS+(Cl)R1 (R = Ph, benzyl, benzamidazol-2-yl, pyridin-2-yl, etc.; R1 = Me, Pr, allyl, vinyl, etc.; RR1 = -CH2S(CH2)3-) demonstrates a new process using these species generated in situ from sulfoxides RS(O)R1 as the source of electrophilic chlorine. The use of highly nucleophilic 1,3,5-trimethoxybenzene (TMB) as the reducing agent is described for the first time and applied in the deoxygenation of simple and functionalized sulfoxides. The method is easy to handle, economic, suitable for gram-scale operations, and readily applied for poly-functionalized mols., as demonstrated with more than 45 examples, including com. medicines and analogs. Also results of competition experiments that define the more reactive sulfoxide, and a mechanistic proposal based on substrate and product observations was reported. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).COA of Formula: C17H19N3O2S

The Article related to sulfide preparation chemoselective, sulfoxide deoxidation, chemoselectivity, deoxygenation, sulfides, sulfonium salts, sulfoxides, synthetic methods, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.COA of Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Yiming; Rizvi, S. Aal-e-Ali; Hu, Deqing; Sun, Danwen; Gao, Anhui; Zhou, Yubo; Li, Jia; Jiang, Xuefeng published an article in 2019, the title of the article was Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

Oxygenation is a fundamental transformation in synthesis. Herein, we describe the selective late-stage oxygenation of sulfur-containing complex mols. with ground-state oxygen under ambient conditions. The high oxidation potential of the active uranyl cation (UO22+) enabled the efficient synthesis of sulfones. The ligand-to-metal charge transfer process (LMCT) from O 2p to U 5f within the O::U::O group, which generates a UV center and an oxygen radical, is assumed to be affected by the solvent and additives, and can be tuned to promote selective sulfoxidation This tunable strategy enabled the batch synthesis of 32 pharmaceuticals and analogs by late-stage oxygenation in an atom- and step-efficient manner. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to photooxidation catalyst uranyl sulfide sulfoxide sulfone, oxygen, oxygenation, photocatalysis, sulfides, uranyl catalysis, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem