Category: 73590-85-9

Dai, Wen; Li, Guosong; Wang, Lianyue; Chen, Bo; Shang, Sensen; Lv, Ying; Gao, Shuang published an article in 2014, the title of the article was Enantioselective oxidation of sulfides with H2O2 catalyzed by a pre-formed manganese complex.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

A variety of sulfide substrates e.g., aryl alkyl, aryl benzyl, cyclic sulfides were oxidized to form their chiral sulfoxides in high yields (up to 95%) and excellent enantioselectivities (>99% ee) in presence of H2O2, pre-formed Mn complex and catalytic amount of adamantoic acid in CH3CN/isopropanol. This synthetic process was environment friendly and the practical utility of the method was demonstrated by the synthesis of esomeprazole and albendazole sulfoxide (ABZO). The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to sulfide manganese complex carboxylic acid catalyst enantioselective oxidation, sulfoxide preparation green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhang, Xu; Zhou, Rui; Qi, Zhengyuan; Chen, Liping; Yu, Lei published an article in 2022, the title of the article was PhSe(O)OH/Al(NO3)3-Catalyzed selectivity controllable oxidation of sulphide owing to the synergistic effect of Se, Al3+ and nitrate.Application of 73590-85-9 And the article contains the following content:

Selective oxidation of sulfides to produce sulfoxides or sulfones is a key technique in industry. In this paper, authors found that the reaction could be catalyzed by a PhSe(O)OH/Al(NO3)3 system in ethanol under mild conditions using H2O2 as the green oxidant. Interestingly, the reaction selectivity could be controlled by adjusting the employed H2O2 amount, affording a potentially applicable method for large scale productions. The synergistic effect of Se, Al3+ and nitrate is the key factor for the reaction. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application of 73590-85-9

The Article related to sulfoxide sulfone preparation phenylseleninic acid aluminum nitrate catalyst, sulfide selective oxidation hydrogen peroxide green oxidant, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.Application of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Anselmi, Silvia; Liu, Siyu; Kim, Seong-Heun; Barry, Sarah M.; Moody, Thomas S.; Castagnolo, Daniele published an article in 2021, the title of the article was A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent.Related Products of 73590-85-9 And the article contains the following content:

A mild, chemoselective and sustainable CALB-biocatalyzed sulfoxidation of sulfides using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate is reported. A series of sulfoxides Ar(CH2)nS(O)R [Ar = Ph, 4-MeC6H4, 2-ClC6H4, etc., R = Me, Et, n-Pr, etc., n = 0, 1], including the drug omeprazole, were synthesized in high yields and with excellent E-factors. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9

The Article related to sulfoxide green preparation chemoselective candida antarctica lipase b catalyst, sulfide sulfoxidation candida antarctica lipase b biocatalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.Related Products of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 5, 2018, Su, Feng; Sun, Ziqing; Su, Weike; Liang, Xianrui published an article.Related Products of 73590-85-9 The title of the article was NMR investigation and theoretical calculations on the tautomerism of benzimidazole compounds. And the article contained the following:

The tautomerism of three benzimidazole compounds: Omeprazole sulfide, 1, (R)-Lansoprazole, 2, and Omeprazole sulfone, 3 were investigated by NMR with the effect of variant solvents and temperature The dielec. constant of the medium and the ability of solvents to form hydrogen bond with the tautomer had a profound effect on the tautomeric equilibration. The chem. shifts and resonance lines of compounds 1-3 differed greatly in different solvent system mainly due to intra- and intermol. hydrogen bonds. Variable temperature-NMR (VT-NMR) experiments showed that at 203 K the two tautomers of compound 1 were separated and determined to be 6:4 and those of compound 3 be 7:3. In contrast, compound 2 presented only one tautomer at the same temperature while the tautomerism was observed again with temperature increasing. The free energy of activation of the tautomeric interchange of compounds 1-3 were 13.77 kcal/mol, 13.47 kcal/mol and 13.06 kcal/mol, resp. D. function theory (DFT) calculations results showed the tautomers of compound 2 had higher energy differences among the three compounds demonstrating only one preferred conformation existed at 203 K. The preferred conformations of compounds 1 and 3 were also given. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9

The Article related to omeprazole sulfide sulfone lansoprazole tautomerism hydrogen bond nmr, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.Related Products of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2013, Li, Yihua; Yang, Wenge; Zhang, Tuan; Wang, Chaoyuan; Wang, Kai; Hu, Yonghong published an article.Category: imidazoles-derivatives The title of the article was Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35-319.65 K. And the article contained the following:

Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, Et acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the 位h equation. The exptl. solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodn. properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van’t Hoff equation. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Category: imidazoles-derivatives

The Article related to solubility omeprazole sulfide solvent temperature range, gravimetric method, omeprazole sulfide, purification, solubility, solution thermodynamics, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 27, 2014, Radaram, Bhasker; Levine, Mindy published an article.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was A green bromination method for the synthesis of benzylic dibromides. And the article contained the following:

Reported herein is the identification of a new methodol. for the dibromination of benzylic diols. This method proceeds in moderate to good yields for a wide variety of electron-deficient, electron-neutral, and electron-rich aromatic substrates. Moreover, the reagent, 1,3-dibromo-5,5-dimethylhydantoin, and the solvent, THF, are substantially more environmentally benign than traditional solvents and reagents used for bromination. The utility of this methodol. was demonstrated in the high-yielding synthesis of a key intermediate in the synthesis of omeprazole. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to benzylic dibromide green preparation, dibromination benzylic diol dibromo dimethylhydantoin, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 7, 2015, Talsi, Evgenii P.; Rybalova, Tatyana V.; Bryliakov, Konstantin P. published an article.Product Details of 73590-85-9 The title of the article was Isoinversion Behavior in the Enantioselective Oxidations of Pyridylmethylthiobenzimidazoles to Chiral Proton Pump Inhibitors on Titanium Salalen Complexes. And the article contained the following:

The oxidation of two pyridylmethylthiobenzimidazoles to proton pump inhibitors (S)-omeprazole and (R)-lansoprazole, and to their enantiomers, with H2O2 is achieved by using chiral titanium salalen complexes as catalysts. The latter ensure high enantioselectivities (up to 96% ee) and efficiencies (TN 200-300), with high sulfoxide yields (up to >96%). The oxidation enantioselectivities vary with temperature in a nonmonotonic manner, demonstrating isoinversion behavior. Maximum enantioselectivity is attained at 273路路路283 K, which temperature region may be recommended for preparative oxidations Kinetic peculiarities and the oxidation mechanism are discussed. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Product Details of 73590-85-9

The Article related to isoinversion behavior enantioselective oxidation pyridylmethylthiobenzimidazole chiral proton pump inhibitor, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Product Details of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 20, 2014, Sun, Li-min; Jiang, Ying-yan; Li, Dong-yue; Zhou, Li-ming; Zheng, De-qiang published an article.Application of 73590-85-9 The title of the article was Improvement of synthesis process of esomeprazole magnesium. And the article contained the following:

Synthesis process of esomeprazole magnesium was improved. With 2-mercapto-5-methoxybenzimidazole and 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine as starting materials, esomeprazole magnesium was synthesized by condensation, asym. oxidation and reaction with magnesium sulfate. The overall yield of esomeprazole magnesium was 67.8%. The improved synthesis process of esomeprazole magnesium can be simple, easily controlled, cost-saving and can provide the product with high purity, and suitable for the industrial production of esomeprazole magnesium. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application of 73590-85-9

The Article related to esomeprazole magnesium proton pump inhibitor synthesis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Application of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ma, Lina; Zhou, Hua; Xu, Ming; Hao, Peipei; Kong, Xianggui; Duan, Haohong published an article in 2021, the title of the article was Integrating hydrogen production with anodic selective oxidation of sulfides over a CoFe layered double hydroxide electrode.Computed Properties of 73590-85-9 And the article contains the following content:

Replacing the sluggish oxygen evolution reaction (OER) with oxidation reactions for the synthesis of complex pharmaceutical mols. coupled with enhanced hydrogen evolution reaction (HER) is highly attractive, but it is rarely explored. Here, we report an electrochem. protocol for selective oxidation of sulfides to sulfoxides over a CoFe layered double hydroxide (CoFe-LDH) anode in an aqueous-MeCN electrolyte, coupled with 2-fold promoted cathodic H2 productivity. This protocol displays high activity (85-96% yields), catalyst stability (10 cycles), and generality (12 examples) in selective sulfide oxidation We demonstrate its applicability in the synthesis of four important pharmaceutical related sulfoxide compounds with scalability (up to 1.79 g). X-ray spectroscopy investigations reveal that the CoFe-LDH material evolved into amorphous CoFe-oxyhydroxide under catalytic conditions. This work may pave the way towards sustainable organic synthesis of valuable pharmaceuticals coupled with H2 production The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Computed Properties of 73590-85-9

The Article related to sulfide cobalt iron layered double hydroxide electrode selective oxidation, Electrochemical, Radiational, and Thermal Energy Technology: Energy Handling, Transport, and Storage and other aspects.Computed Properties of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 31, 2010, Mahale, Rajendra D.; Rajput, Mahesh R.; Maikap, Golak C.; Gurjar, Mukund K. published an article.Application of 73590-85-9 The title of the article was Davis Oxaziridine-Mediated Asymmetric Synthesis of Proton Pump Inhibitors Using DBU Salt of Prochiral Sulfide. And the article contained the following:

A simple and clean asym. synthesis of proton pump inhibitors using inexpensive 10-camphorsulfonyl oxaziridine is described. The activation of prochiral sulfide is based on use of the DBU salt which is capable of enhancing the reactivity and enantioselectivity. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application of 73590-85-9

The Article related to camphorsulfonyl oxaziridine asym sulfoxidation sulfide omeprazole ppi preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Application of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem