Category: 73590-85-9

Hafez, H. M.; Elshanawany, A. A.; Abdelaziz, L. M.; Mohram, M. S. published an article in 2015, the title of the article was Stability indicating HPLC method for drugs indicated for helicobacter pylori-associated ulcers.Quality Control of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

Triple therapy regimen that comprises a proton pump inhibitor likes Omeprazole, antibiotics like Doxycycline and Tinidazole can be used for treatment of peptic ulceration which is caused by H. pylori. A validated HPLC method was developed as a stability-indicating HPLC method for these drugs and its impurities. New method overcame interference between Doxycycline and its epimer on achiral column by using a chiral mobile phase. The method was performed on Phenomenex BDS HYPERSIL C18 5 μm 100A (250×4.6 mm) and the mobile phase consisted of (1S)-(+)-Campher-10-sulfonic acid (0.01M) and Edetate disodium (0.001M) (pH=4.5) Acetonitrile which pumped at a flow rate 1.2 mL/min in gradient manner at 40°C. 20 μl of drugs sample solutions were monitored at wavelength 310 nm. Tinidazole, Doxycycline and Omeprazole and Trio capsule bulk powders were stressed under different conditions in forced degradation studies. Method validation was developed following the recommendations for anal. method validation of International Conference on Harmonization (ICH) and Food and Drug Administration (FDA) organizations. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Quality Control of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to helicobacter ulcer omeprazole doxycycline tinidazole stability hplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Quality Control of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 5, 2010, Zanitti, Leo; Ferretti, Rosella; Gallinella, Bruno; La Torre, Francesco; Sanna, Maria Luisa; Mosca, Antonina; Cirilli, Roberto published an article.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Direct HPLC enantioseparation of omeprazole and its chiral impurities: Application to the determination of enantiomeric purity of esomeprazole magnesium trihydrate. And the article contained the following:

Anal. and semipreparative high-performance liquid chromatog. (HPLC) enantioseparation of the proton-pump inhibitor omeprazole (OME) and its potential organic chiral impurities were accomplished on the immobilized-type Chiralpak IA chiral stationary phase (CSP) under both polar organic and normal-phase conditions. The (S)-enantiomers were isolated with a purity of >99% ee and their absolute configuration was empirically assigned by CD spectroscopy. A chemo- and enantioselective HPLC method was validated to control the enantiomeric purity of the (S)-enantiomer of OME (ESO), an active ingredient contained in drug products, in the presence of chiral and achiral related substances. The precision, linearity and accuracy of the determination of the (R)-impurity as well as the recovery of ESO from a pharmaceutical preparation were determined The proposed method uses the mixture Me tert-butylether (MtBE)-Et acetate (EA)-EtOH (EtOH)-diethylamine (DEA) 60:40:5:0.1 (volume/volume/volume/volume) as a mobile phase. In these conditions, linearity over the concentration range 0.5-25 μg/mL for (R)-enantiomer was obtained. The limits of detection and quantification were 99 and 333 ng/mL, resp. The intra and inter-day assay precision was <2% (RSD%). The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to omeprazole impurity determination hplc enantioseparation, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Recommanded Product: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 2010, Trivedi, Harshal K.; Patel, Mukesh C. published an article.COA of Formula: C17H19N3O2S The title of the article was Development and validation of a precise single HPLC method for determination of omeprazole and its related compound in pharmaceutical formulation. And the article contained the following:

A simple reversed-phase high performance liquid chromatog. was developed and employed for the determination of omeprazole and its related substances in bulk material and com. dosage forms. A gradient elution of filtered sample was performed on Zorbax XDB C8 (150 × 4.6), 5μ column with Glacine buffer (pH-8.8) as a mobile phase-A, Acetonitrile : Methanol (83:17) as a mobile phase-B and UV detection at 302 nm. Mobile phase was delivered at flow of 1.2 mL/min and at maintaining the column temperature at 25°C, quantification was achieved with reference to the external standards The active ingredient – omeprazole was successfully separated from its all related substances, including process impurities and other possible impurities of oxidation and decomposition The excipients did not interfere with the determination of omeprazole and its related compound in com. dosage formulations. The method was rapid, simple, accurate and reproducible. It was not only successfully employed for the assay of omeprazole in bulk material and pharmaceutical dosage forms but also for the determination of its related substances. A statistical design of experiments was used for the robustness evaluation of HPLC anal. method. All results were acceptable and confirmed that the method is suitable for its intended use. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).COA of Formula: C17H19N3O2S

The Article related to omeprazole determination impurity reversed phase hplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.COA of Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mahesh, H. R. K.; Babu, K. Sudhakar; Ram Prasad, Lanka A.; Pamidi, Srinivasu published an article in 2015, the title of the article was Simultaneous estimation of related compounds in Esomeprazole and Naproxen tablets by using ion pair reverse phase HPLC.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

Objective: To develop and validate a novel gradient reverse phase HPLC method for quant. estimation of Naproxen and Esomeprazole impurities in pharmaceutical dosage form. Methods: Chromatog. separation was achieved on X-Bridge C18,150 × 4.6 mm, 3.5 μm column. Detection wavelength was set at 302 nm. The mobile phase A consists of Buffer and Acetonitrile in the ratio of 90:10, where Buffer was prepared by dissolving di ammonium hydrogen phosphate (2.64 gm per L) and 1-hexane sulfonic acid sodium salt (1.0 gm per L), pH adjusted to 6.5±0.05 with orthophosphoric acid. A mixture of acetonitrile and 1-propanol in the ratio of 90:10 was used as mobile phase B. Flow rate was set to 0.7 mL/min in gradient elution mode, with a retention time for Naproxen and Esomeprazole 29 and 46 min resp. Results: The calibration curve was linear over the concentration range of 4.621 μg/mL-99.026 μg/mL for Naproxen and 0.254 μg/mL-3.806 μg/mL for Esomeprazole (r = 0.999). The proposed method was found to be (considered)accurate and precise and linear within the desired range. The limit of quantitation (LOQ) was calculated The purity angle was found less than purity threshold for forced degradation peaks, which shows there was no interference from the common excipient, known impurities and degradents indicating separation, accuracy and reliability of the method. The method was validated as per ICH guidelines and found to be specific, accurate, linear, precise and stability indicating. Conclusion: A Novel, simple, selective and rapid reversed phase high performance liquid chromatog. (HPLC) method was developed and validated for the estimation of Naproxen and Esomeprazole impurities in pharmaceutical dosage form. Hence, the method can be used for routine anal. in various pharmaceutical industries. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to esomeprazole naproxen tablet reverse phase hplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 2014, Schmidt, Alexander H.; Stanic, Mijo published an article.COA of Formula: C17H19N3O2S The title of the article was Rapid UHPLC method development for: omeprazole analysis in a quality-by-design framework and transfer to HPLC using chromatographic modelling. And the article contained the following:

The aim of this study was to apply quality-by-design principles to build in a more scientific and risk-based multifactorial strategy in the development of an ultrahigh-pressure liquid chromatog. (UHPLC) method for omeprazole and its related impurities. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).COA of Formula: C17H19N3O2S

The Article related to ultrahigh pressure liquid chromatog omeprazole, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.COA of Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dong, Qixin; Zhu, Jiajun; Sui, Qiang; Tang, Chao; Wang, Xiaomei; Yu, Yunqiu published an article in 2013, the title of the article was Optimization of mobile phase for the determination of Esomeprazole and related compounds and investigation of stress degradation by LC-MS.Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

In this study, the objective was to investigate the degradation behavior of Esomeprazole under different recommended stress conditions according to International Conference on Harmonization of Tech. Requirements for Registration of Pharmaceuticals for Human Use [1] by HPLC. Our research showed that the effect of mobile phase species on separation was significant for the determination of Esomeprazole and its related compounds Successful separation of the drug from its related impurities and degradation products formed under different stress conditions was achieved using ammonium acetate buffer/ACN by a gradient elution. Compared with phosphate buffer/ACN, ammonium acetate buffer/ACN under same pH and gradient showed a great improvement in resolution due to the change of elution order. The drug was subjected to stress conditions including acidic, alk., oxidative, photolytic, and thermal conditions. Extensive degradation occurred in acidic and oxidative conditions, while mild degradation was observed in alk. and photolytic conditions. Besides, it turned out the drug was extremely stable under thermal condition. The stability-indicating LC-UV method was validated with respect to linearity, precision, accuracy, specificity, and robustness. The LC-MS method was also adopted for the characterization of degradation products. Based on the m/z values and fragmentation patterns, the degradation pathway of the drug has been proposed. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to esomeprazole stress degradation product lc ms, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mohan, T. S. S. Jagan; Varma, Datla Peda; Bhavyasri, Khagga; Prasad, Kancherla; Mukkanti, Khagga; Jogia, Hitesh A. published an article in 2017, the title of the article was HPLC method for determining esomeprazole and its related substances in pharmaceutical formulations.Application of 73590-85-9 And the article contains the following content:

A green, novel, selective, rapid, precise, accurate and simple isocratic reverse phase stability indicating RP-HPLC method has been developed and validated as per ICH guidelines for estimation of esomeprazole and its impurities in pharmaceutical formulations. Inertsil ODS (150 × 4.6 mm, 5 μ) stationary phase by using mobile phase 0.05 % glacial acetic acid and isopropanol in the ratio of 85:15 volume/volume at flow rate of 1.0 mL/min and column temperature of 50 °C. Esomeprazole was detected at 280 nm. The proposed method was validated as per ICH guidelines for precision, accuracy, specificity, robustness and sensitivity. The proposed method proves its stability by resolving esomeprazole peak from its degradation products in forced degradation study. The proposed method is not only eco-friendly but faster than the official method in EP 8.0 by meeting resolution criteria as per the monograph. The proposed method was capable to determine assay of esomeprazole in the presence of its related substances within the same run. The proposed method can be used for routine anal. in quality control laboratories for its pharmaceutical formulations. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Application of 73590-85-9

The Article related to esomeprazole impurity tablet formulation hplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Liu, Hong; Li, Yuan; Chen, Yan; Zhao, Haipeng published an article in 2015, the title of the article was Main component self-comparison with calibration factor method for determination of related substances in Omeprazole Enteric Capsules.Product Details of 73590-85-9 And the article contains the following content:

Objective: To establish the main component self-comparison with calibration factor method to determine the contents of related substances in Omeprazole Enteric Capsules. Methods: An Agilent HC-C8 column (4.6 mm × 250 mm, 5 μm) was adopted with the mobile phase composed of 0.01 mol·L-1 disodium hydrogen phosphate (adjusted to pH 7.6 with phosphoric acid) and acetonitrile in the ratio of 75:25 pumped at a flow rate of 1.0 mL·min-1. The detection was carried out at 280 nm and a column temperature of 35°C. The injection volume was 20 μL. The slope of linear equation was used to determine the correction factor between impurities A, B, C, D and omeprazole. The relative retention time was used to determine the position of impurities. Results: The relative retention time between impurities A, B, C, D and omeprazole was 0.27, 0.31, 0.41 and 0.79, resp. The correction factor of impurities A, B, C, D was 1.20, 0.58, 0.57 and 1.04, resp. The content of impurity D was 0.022% in three batches of samples. Other impurities were not detected. Conclusion: The method is simple, efficient and accurate for analyzing the related substances in Omeprazole Enteric Capsules. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Product Details of 73590-85-9

The Article related to omeprazole enteric capsule related substance, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Product Details of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On June 30, 2016, Koppala, Srinivasarao; Ranga Reddy, V.; Anireddy, Jaya Shree published an article.Electric Literature of 73590-85-9 The title of the article was Development and validation of a novel stability-indicating RP-HPLC method for the simultaneous determination of related substances of ketoprofen and omeprazole in combined capsule dosage form. And the article contained the following:

A novel, simple, sensitive, selective and reproducible stability-indicating high performance liquid chromatog. method was developed for the quant. determination of degradation products and process-related impurities of ketoprofen (KET) and omeprazole (OMZ) in combined oral solid dosage form. Chromatog. separation was achieved on a Phenomenex Luna C18 (2) column (150 × 4.6 mm, 5 μm) under gradient elution by using a binary mixture of potassium dihydrogen phosphate buffer and acetonitrile at a flow rate of 0.8 mL/min. Chromatogram was monitored at 233 nm for KET impurities and at 305 nm for OMZ impurities using a dual wavelength UV detector. Resolution for KET and OMZ and 14 impurities was found to be >1.5 for any pair of components. Typical retention behaviors of impurities at various pH values were depicted graphically. To prove the stability-indicating power of the method, the drug product was subjected to hydrolytic, oxidative, photolytic, humidity and thermal stress conditions as per ICH. The developed method was validated according to the current ICH guidelines for specificity, limit of detection, limit of quantification, linearity, accuracy, precision, ruggedness and robustness. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Electric Literature of 73590-85-9

The Article related to ketoprofen omeprazole capsule rp hplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Electric Literature of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 31, 2008, Koneva, E. A.; Khomenko, T. M.; Kurbakova, S. Yu.; Komarova, N. I.; Korchagina, D. V.; Volcho, K. P.; Salakhutdinov, N. F.; Tolstikov, A. G.; Tolstikov, G. A. published an article.Recommanded Product: 73590-85-9 The title of the article was Synthesis of optically active omeprazole by catalysis with vanadyl complexes with chiral Schiff bases. And the article contained the following:

A new method for the preparation of optically active omeprazole I via asym. oxidation of the corresponding sulfide with the use of vanadyl complexes with chiral Schiff bases as the catalysts has been elaborated. The best yields and enantioselectivity of the oxidation were achieved using the complex of VO(acac)2 with ligand II. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 73590-85-9

The Article related to enantioselective omeprazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Recommanded Product: 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem