Category: 73590-85-9

On March 31, 2009, Jiang, Biao; Zhao, Xiao-Long; Dong, Jia-Jia; Wang, Wan-Jun published an article.Formula: C17H19N3O2S The title of the article was Catalytic asymmetric oxidation of heteroaromatic sulfides with tert-butyl hydroperoxide catalyzed by a titanium complex with a new chiral 1,2-diphenylethane-1,2-diol ligand. And the article contained the following:

Heteroaromatic sulfoxides, especially 1H-benzimidazolyl pyridinylmethyl sulfoxides, usually used as the blockbuster gastric proton pump inhibitors (PPIs), have been prepared highly enantioselectivity by catalytic asym. oxidation of sulfides attached to nitrogen-containing heterocycles with tert-Bu hydroperoxide in the presence of a chiral titanium complex, formed in situ from Ti(iPrO)4, chiral 1,2-diphenylethane-1,2-diol and water. The chiral sulfoxides were obtained in high yield (97%) with excellent enantiomeric excess (up to 98%). The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Formula: C17H19N3O2S

The Article related to benzimidazolyl pyridinylmethyl benzyl sulfide tertbutyl hydroperoxide titanium, chiral diphenylethane diol asym oxidation sulfoxide stereoselective preparation, asym oxidation catalyst titanium chiral diphenylethane diol and other aspects.Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 18, 2008, Sun, Jiangtao; Yang, Minghua; Dai, Zhenya; Zhu, Chengjian; Hu, Hongwen published an article.Electric Literature of 73590-85-9 The title of the article was Synthesis of optically active 2,5-dialkylcyclohexane-1,4-diols and their application in the asymmetric oxidation of sulfides. And the article contained the following:

A simple and efficient approach to obtain optically pure 1,4-diols was established. The asym. oxidation of sulfides to sulfoxides with cumyl hydroperoxide in moderate yields and moderate to high enantioselectivities (≤84%) catalyzed by chiral Ti/1,4-diols complexes was achieved. An ee of 76% was obtained in the asym. synthesis of esomeprazole. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Electric Literature of 73590-85-9

The Article related to alkylcyclohexanediol resolution chiral ligand titanium catalyzed asym oxidation, sulfide asym oxidation titanium catalyst, thioether asym oxidation titanium catalyst, sulfoxide asym synthesis, esomeprazole asym synthesis and other aspects.Electric Literature of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Boix, C.; Ibanez, M.; Sancho, J. V.; Niessen, W. M. A.; Hernandez, F. published an article in 2013, the title of the article was Investigating the presence of omeprazole in waters by liquid chromatography coupled to low and high resolution mass spectrometry: degradation experiments.Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole And the article contains the following content:

Omeprazole is one of the most consumed pharmaceuticals around the world. However, this compound is scarcely detected in urban wastewater and surface water. The absence of this pharmaceutical in the aquatic ecosystem might be due to its degradation in wastewater treatment plants, as well as in receiving water. Different laboratory-controlled degradation experiments were carried out on surface water to elucidate omeprazole transformation products (TPs). Surface water spiked with omeprazole was subjected to hydrolysis, photo-degradation under both sunlight and UV radiation and chlorination. Analyses by liquid chromatog. coupled to quadrupole time-of-flight mass spectrometry (LC-QTOF MS) permitted identification of ≤17 omeprazole TPs. In a subsequent step, the TPs identified were sought in surface water and urban wastewater by LC-QTOF MS and by LC coupled to tandem mass spectrometry with triple quadrupole. The parent omeprazole was not detected in any of the samples, but 4 TPs were found in several water samples. The most frequently detected compound was OTP 5 (omeprazole sulfide), which might be a reasonable candidate to be included in monitoring programs rather than the parent omeprazole. Copyright pr 2013 John Wiley & Sons, Ltd. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to omeprazole water liquid chromatog mass spectrometry degradation, omeprazole, surface water, time-of-flight mass spectrometry, transformation/degradation products, triple quadrupole mass spectrometry, ultra-high-performance liquid chromatography, urban wastewater and other aspects.Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gaudencio, Susana P.; Pereira, Florbela published an article in 2020, the title of the article was A computer-aided drug design approach to predict marine drug-like leads for SARS-CoV-2 main protease inhibition.Recommanded Product: 73590-85-9 And the article contains the following content:

The investigation of marine natural products (MNPs) as key resources for the discovery of drugs to mitigate the COVID-19 pandemic is a developing field. In this work, computer-aided drug design (CADD) approaches comprising ligand- and structure-based methods were explored for predicting SARS-CoV-2 main protease (Mpro) inhibitors. The CADD ligand-based method used a quant. structure-activity relationship (QSAR) classification model that was built using 5276 organic mols. extracted from the ChEMBL database with SARS-CoV-2 screening data. The best model achieved an overall predictive accuracy of up to 67% for an external and internal validation using test and training sets. Moreover, based on the best QSAR model, a virtual screening campaign was carried out using 11,162 MNPs retrieved from the Reaxys database, 7 inhouse MNPs obtained from marine-derived actinomycetes by the team, and 14 MNPs that are currently in the clin. pipeline. All the MNPs from the virtual screening libraries that were predicted as belonging to class A were selected for the CADD structure-based method. In the CADD structure-based approach, the 494 MNPs selected by the QSAR approach were screened by mol. docking against Mpro enzyme. A list of virtual screening hits comprising fifteen MNPs was assented by establishing several limits in this CADD approach, and five MNPs were proposed as the most promising marine drug-like leads as SARS-CoV-2 Mpro inhibitors, a benzo[f]pyrano[4,3-b]chromene, notoamide I, emindole SB beta-mannoside, and two bromoindole derivatives The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 73590-85-9

The Article related to computer aided drug sars cov protease inhibition, actinomycetes, drug discovery, machine learning (ml) techniques, main protease enzyme (mpro), marine natural products (mnps), molecular docking, quantitative structure–activity relationship (qsar), severe acute respiratory syndrome coronavirus 2 (sars-cov-2), virtual screening and other aspects.Recommanded Product: 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem