Category: 72721-02-9

Thomann, Andreas published the artcileMicrowave-assisted synthesis of 4-substituted 2-methylthiopyrimidines, Recommanded Product: 5,6-Dimethoxy-1H-benzo[d]imidazole, the main research area is chloromethylthiopyrimidine heterocycle aromatic substitution microwave irradiation; heterocycle substituted methylthiopyrimidine preparation green chem.

Typically, SNAr reactions at 4-chloro-2-methylthiopyrimidine are carried out employing DMF and sodium hydride under inert gas as well as prolonged reaction times. Herein, we describe a mild and rapid microwave-assisted synthesis to achieve 4-substituted 2-methylthiopyrimidines from the corresponding chlorine precursor. Moderate to excellent yields were obtained in a green chem. fashion requiring only few minutes of reaction time.

Synlett published new progress about Green chemistry. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, Recommanded Product: 5,6-Dimethoxy-1H-benzo[d]imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Volynets, Galyna published the artcileIdentification of protein kinase fibroblast growth factor receptor 1 (FGFR1) inhibitors among the derivatives of 5-(5,6-dimethoxybenzimidazol-1-yl)-3-hydroxythiophene-2-carboxylic acid, Application of 5,6-Dimethoxy-1H-benzo[d]imidazole, the main research area is dimethoxy benzimidazolyl hydroxythiophene carboxylate preparation FGFR1 inhibitor cancer.

Abstract: Fibroblast growth factor receptor 1 (FGFR1) plays an important role in tumorigenesis, suggesting that inhibitors of this protein kinase may become important compounds for the development of anticancer agents. Using mol. docking approach, we have identified a novel class of FGFR1 inhibitors belonging to the derivatives of 5-(5,6-dimethoxybenzimidazol-1-yl)-3-hydroxythiophene-2-carboxylic acid. It was revealed that the most promising compound 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[2-(methanesulfonyl)benzyloxy]thiophene-2-carboxylic acid Me ester inhibits FGFR1 with an IC50 value of 150 nM in in vitro kinase assay. The structure-activity relationships have been studied, and the binding mode of this chem. class has been proposed. Graphic abstract: [Figure not available: see fulltext.].

Monatshefte fuer Chemie published new progress about Antitumor agents. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, Application of 5,6-Dimethoxy-1H-benzo[d]imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kiselyov, Alexander S. published the artcile2-((1H-Azol-1-yl)methyl)-N-arylbenzamides: Novel dual inhibitors of VEGFR-1/2 kinases, COA of Formula: C9H10N2O2, the main research area is azolyl arylbenzamide preparation VEGFR kinase inhibitor SAR.

Novel potent derivatives of (azol-1-yl)methyl-N-arylbenzamides with improved solubility (>3 mM) are described as ATP-competitive inhibitors of vascular endothelial growth factor receptor 2 (VEGFR-2). Many compounds display VEGFR-2 inhibitory activity reaching IC50 < 100 nM in the enzymic assay. The compounds also inhibit the related tyrosine kinase, VEGFR-1, with similar potencies. Several compounds containing bulky lipophilic substituents at the benzamide pharmacophore yielded 10- to 17-fold selectivity for the VEGFR-2 vs. VEGFR-1 kinase. Bioorganic & Medicinal Chemistry Letters published new progress about Molecular modeling. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, COA of Formula: C9H10N2O2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Feng, Zihao published the artcileConstruction and investigation of chiral and photoluminescent Metal-Organic framework based on Zn(II) ions and achiral methoxy-functionalized benzimidazolate linkers, SDS of cas: 72721-02-9, the main research area is dimethoxy benzimidazolate zinc metal organic framework preparation crystal structure; chiral photoluminescent dimethoxy benzimidazolate zinc MOF preparation crystal structure.

A Zn(II)-based metal-organic framework, namely MeOBim-Zn (1), has been prepared by the reaction between 5,6-dimethoxy-1H-benzo[d]imidazole (MeOBimH) and Zn(NO3)2 in the presence of aqueous ammonia through solvothermal method and characterized by single-crystal x-ray diffraction, TGA and FT-IR. 1 Exhibits a (10,3)-a chiral network constructing from achiral MeOBim- linker and Zn(II) ions via spontaneous resolution In addition, 1 shows photoluminescent emission at 433 nm upon photoexcitation at 365 nm and this emission may originate from dissipation of metal-perturbed π(MeOBim-) to π*(MeOBim-) intraligand (IL) excited state.

Inorganic Chemistry Communications published new progress about Crystal structure. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, SDS of cas: 72721-02-9.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ping, Kefeng published the artcileFused Hybrid Linkers for Metal-Organic Framework-Derived Bifunctional Oxygen Electrocatalysts, SDS of cas: 72721-02-9, the main research area is metal organic framework hybrid linker oxygen evolution reaction electrocatalyst.

Preparation of electrocatalysts often relies on the use of multiple starting materials, with examples arising from a single precursor being less common. A series of heterobivalent scaffolds are surveyed to identify an iron/benzimidazole-based metal-organic framework as a uniform starting material. By merging the catechol and imidazole units together, a direct entry is obtained into a highly efficient bifunctional oxygen electrocatalyst, which alleviates the need for dopants and modifying conditions. It is demonstrated that by fine-tuning the chem. nature of an organic linker, one is able to modulate the electrochem. properties of a single precursor-derived electrocatalyst material.

ACS Applied Energy Materials published new progress about Electrochemical reaction catalysts. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, SDS of cas: 72721-02-9.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

MaGee, Karen D. M. published the artcileSynthesis, Solid-state Structures, Solution Behaviour and Catalysis Studies of Nickel Complexes of Bis(benzimidazolin-2-ylidene)pyridine Pincer Ligands, SDS of cas: 72721-02-9, the main research area is crystal structure benzimidazolinylidenepyridine pincer nickel preparation catalyst Kumada coupling; mol structure benzimidazolinylidenepyridine pincer nickel preparation catalyst Kumada coupling; aryl halide Kumada Grignard catalyst benzimidazolinylidenepyridine NHC pincer nickel.

N-Heterocyclic carbene-Ni complexes with five- and four-coordinate geometries [(CNC)NiBr2] and [(CNC)NiBr]X (X = PF6 or BPh4) were prepared with the pincer ligands 2,6-bis(N-octylbenzimidazolin-2-ylidene)pyridine and 2,6-bis(N-butyl-5,6-dimethoxybenzimidazolin-2-ylidene)pyridine. The addition of the n-octyl substituent significantly extends the solubility of the complexes and has allowed UV-visible solution studies of the complexes in CH2Cl2 and MeOH. The four- and five-coordinate species exist in equilibrium in solution and this equilibrium was explored by UV-visible studies. The complexes also were characterized by NMR studies, and single crystal x-ray diffraction studies were performed on [(CNC)NiBr2] (CNC = 2,6-bis(N-octylbenzimidazolin-2-ylidene)pyridine) and [(CNC)NiBr]BPh4 (CNC = 2,6-bis(N-butyl-5,6-dimethoxybenzimidazolin-2-ylidene)pyridine). The Ni complexes displayed only moderate activity in Tamao-Kumada-Corriu coupling reactions.

Australian Journal of Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, SDS of cas: 72721-02-9.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ohshima, Etsuo published the artcileNon-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 2, Related Products of imidazoles-derivatives, the main research area is benzimidazolylethylidenedibenzoxepincarboxylic acid thromboxane receptor antagonist.

A series of 11-[2-(1-benzimidazolyl)ethylidene]-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid derivatives and related compounds were synthesized and found to be potent TXA2/PGH2 receptor antagonists. Each compound synthesized was tested for its ability to displace [3H]U-46619 binding from guinea pig platelet TXA2/PGH2 receptors. Structure-activity relationship studies revealed that the following key elements were required for enhanced activities: (1) an (E)-2-(1-benzimidazolyl)ethylidene side chain in the 11-position of the dibenzoxepin ring system and (2) a carboxyl group in the 2-position of the dibenzoxepin ring system. The studies also indicated that the TXA2/PGH2 receptor binding affinities of this series of compounds in guinea pig platelet were poorly correlated with those in human platelet. Introduction of substituent(s) to the benzimidazole moiety was effective and sodium (E)-11-[2-(5,6-dimethyl-1-benzimidazolyl)ethylidene]-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate monohydrate (I) recorded the highest affinity for human platelet TXA2PGH2 receptor with a Ki value of 1.2 ± 0.14 nM. It demonstrated potent inhibitory effects on U-46619-induced guinea pig platelet aggregation (in vitro and ex vivo) and human platelet aggregation (in vitro). Compound I is a novel, orally active, and specific TXA2/PGH2 receptor antagonist with neither TXA2/PGH2 receptor agonistic nor TXA2 synthase inhibitory effects.

Journal of Medicinal Chemistry published new progress about Thromboxane receptor TBXA2R Role: SPN (Synthetic Preparation), PREP (Preparation). 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bamborough, Paul published the artcile5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase, Safety of 5,6-Dimethoxy-1H-benzo[d]imidazole, the main research area is IKK kinase inhibitor benzimidazolyl thiophenecarbonitrile preparation SAR.

The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-ε kinase is described. Compound 12e (I) was identified with an IKK-ε enzyme potency of pIC50 7.4, and has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.

Bioorganic & Medicinal Chemistry Letters published new progress about Epidermal growth factor receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, Safety of 5,6-Dimethoxy-1H-benzo[d]imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Meng published the artcileCopper-catalyzed N-arylation and aerobic oxidative C-H/C-H coupling: one-pot synthesis of indoloimidazoquinoline derivatives, Recommanded Product: 5,6-Dimethoxy-1H-benzo[d]imidazole, the main research area is copper arylation aerobic oxidation coupling indoloimidazoquinoline preparation; benzimidazoindoloquinoline preparation.

A novel and efficient copper-catalyzed one-pot synthesis of indoloimidazoquinoline derivatives has been developed. The synthesis of the target compounds was achieved by a protocol using readily available substituted 2-(2-bromophenyl)-1H-indole derivatives, imidazole and benzimidazole derivatives as starting materials, inexpensive copper bromide (CuBr) as a catalyst, air as a terminal oxidant. The procedure underwent a sequential copper-catalyzed intermol. N-arylation and an aerobic oxidative intramol. C-H/C-H coupling. The title compounds thus formed included a heterocyclic compound (I) [i.e., 5H-benzimidazo[1,2-a]indolo[3,2-c]quinoline] and related substances, such as 9H-imidazo[1,2-a]indolo[3,2-c]quinoline.

RSC Advances published new progress about Arylation. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, Recommanded Product: 5,6-Dimethoxy-1H-benzo[d]imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem