Category: 72459-45-1

Electric Literature of 72459-45-1, A common heterocyclic compound, 72459-45-1, name is 1-(2-Bromobenzyl)-1H-imidazole, molecular formula is C10H9BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 7 (COMPOUND 7) 2-Bromophenyl-1-(1-hydroxycycloheptyl)-1-imidazolylmethane A solution of lithium diisopropylamide in 100 ml of tetrahydrofuran was prepared at -30 C. from 5.1 g (50 mmol) of diisopropylamine and 30 ml (50 mmol) of n-butyllithium in hexane. 11.85 g (50 mmol) of N-(2-bromobenzyl)-imidazole were added dropwise to this solution at -78 C., stirring was carried out for half an hour and 5.6 g (50 mmol) of cycloheptanone were then added at this temperature. The reaction mixture was warmed up to room temperature in the course of 3 hours and worked up with water and methylene chloride. 12 g of crude product were obtained, and this product gave 5.5 g of an imidazole derivative of melting point 108 C. after recrystallization with cyclohexane/ethyl acetate.

The synthetic route of 72459-45-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoechst Aktiengesellschaft; US4876354; (1989); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 72459-45-1,Some common heterocyclic compound, 72459-45-1, name is 1-(2-Bromobenzyl)-1H-imidazole, molecular formula is C10H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1- (2-Bromo-benzyl) -1H-imidazole (20 g, 84.0 mmol),Palladium acetate (500 mg),Triphenylphosphine (500 mg),Potassium carbonate (23 g, 167 mmol) was dissolved in DMSO (200 mL)The mixture was heated to 140 C under nitrogen for 2 hours.LC-MS showed the reaction was complete,The reaction solution was concentrated to dryness,The residue was dissolved in ethyl acetate (200 mL)Water (2 × 100 mL),Saturated brine (50 mL).Organic phase filtration,concentrate.The residue obtained 5H- imidazo [5,1-a] isoindole (10.0 g) was purified by flash silica gel column.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2-Bromobenzyl)-1H-imidazole, its application will become more common.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Tong Chaolong; Bao Rudi; Li Yuannian; (67 pag.)CN107312005; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem