Category: 72-40-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 72-40-2, name is 5-Amino-1H-imidazole-4-carboxamide hydrochloride, A new synthetic method of this compound is introduced below., Safety of 5-Amino-1H-imidazole-4-carboxamide hydrochloride

AIL round-bottom flask (three neck) containing 340 g of trifluoroacetamide was heated in an oil bath at [110 C.] After the trifluoroacetamide melted, 50 g of 5- [AMINOIMIDAZOLE-4-CARBOXAMIDE-HCL] was added. The mixture was warmed to reflux (bath temp 160 to [165 C)] for 4 hours, cooled to room temperature, and the rocky solid was triturated with [1] L of ether. The ether was decanted off and the remaining solid was warmed until melted and 200 mL of ether was introduced by a dropping-funnel through a water-cooled condenser. The mixture was cooled to room temperature and an additional 200 mL of ether was added with stirring. The solid was removed by filtration, triturated with 3 x 500 mL of ether, washed with 200 mL of H20, and filtered to provide 89 g of crude product. The product was treated with 3 L [OF MEOH] and 9 g of activated carbon, warmed to reflux for 20 minutes, filtered through a pad of celite, and concentrated to a volume of 2.5 L. The material was warmed to dissolve all the precipitate that formed and then cooled slowly to room temperature. The crystalline material was isolated by filtration and dried in vacuo to provide 41 g of the desired hypoxanthine as a white solid. [‘H] NMR (DMSO-d6) [S] 8. 34 (s, 1H), 7.18 (bs, 2H). MS (ES+), 205.0 (100%, M + H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2004/14913; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 72-40-2,Some common heterocyclic compound, 72-40-2, name is 5-Amino-1H-imidazole-4-carboxamide hydrochloride, molecular formula is C4H7ClN4O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-amino-5-imidazolecarboxamide hydrochloride was heated to reflux in phosphorus oxychloride for 3.5 hs and after purification gave 4-amino-5-nitrile imidazole. This was resuspended in ethanol saturated with HCl overnight and purification gave 4-amino-5-ethylimino ester imidazole hydrochloride. This was combined with diphenylborinic acid ethanolamine ester in tetrahydrofuran (THF) overnight to yield the title compound.

The synthetic route of 72-40-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Benkovic, Stephen J.; Shapiro, Lucy; Wright, Rachel; Stephens, Craig; Kahng, Lyn Sue; Berdis, Anthony; Lee, Irene; US2005/227933; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 72-40-2, These common heterocyclic compound, 72-40-2, name is 5-Amino-1H-imidazole-4-carboxamide hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 4-aminoimidazole-5-carboxamide hydrochloride [0957] (1 g, 6.151 mmol) in N,N-dimethylformamide (5 mL) was added ethylxanthic acid potassium salt (1.479 g, 9.226) and the mixture was heated at 140 C. for 5 h. The reaction mixture was concentrated under reduced pressure. The residue was triturated with acetonitrile (20 mL). The solid was filtered, washed with acetonitrile (10 mL) and dried under vacuum to afford 2-mercapto-1,9-dihydro-6H-purin-6-one [0958] as a brown solid (0.8 g, 77%). MS(M+1)+=169.0.

The synthetic route of 72-40-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cadent Therapeutics, Inc.; Jefson, Martin R.; Keaney, Gregg F.; Larsen, Janus Schreiber; Lowe, III, John A.; McCall, John M.; (110 pag.)US2017/355708; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 72-40-2, name is 5-Amino-1H-imidazole-4-carboxamide hydrochloride, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 72-40-2, COA of Formula: C4H7ClN4O

[0161] Synthesis of 2-methyl-N-(naphthalen-2-yl)-9H-purin-6-amine.; [0162] This compound is synthesized according the scheme above and is characterized as follows: melting point: 85 0C. 1H NMR (300 MHz, DMSO-d6): d 10.45 (brs, NH, exchangeable), 8.65 (s, IH), 8.57 (s, IH), 7.91-7.99 (m, 4H), 7.46-7.56 (m, 2H), 2.71 (s, 3H); MS m/z : 276.1 (M + H+).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM; UNIVERSITY OF WASHINGTON; WO2009/82691; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 72-40-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 72-40-2 as follows.

Example 1 Preparation of Temozolomide (1) 5-Amino-1H-imidazole-4-carboxamide.HCl (4) (25 g, 0.154 mol) (Aldrich 16,496-8), CH2Cl2(0.6 L) and Et3N (45 mL) (Aldrich, 13,206-3) were placed into a dry 2-liter, three-necked flask equipped with dropping funnel, a gas inlet tube, a gas outlet tube, reflux condenser and mechanical stirrer, and maintained under a positive pressure of nitrogen at ambient temperature. The mixture was stirred, and a solution of 400 mL of 4-nitrophenyl chloroformate (34 g, 0.169 mol) (Aldrich, 16,021-0) in CH2Cl2 was added dropwise. The reaction mixture was stirred vigorously for 4 hours and then left to stand for 18 hours at room temperature. The precipitate was collected by vacuum filtration and washed with H2O (1.5 L) to afford the product (3) as a pale yellow solid (42 g, 0.144 mol). 1H NMR (400 MHz, DMSO-d6, delta): 8.40 (d, 2H), 7.83 (s, 1H), 7.74 (d, 2H), 7.08 (bs, 1H), 6.95 (bs, 1H), 6.52 (s, 2H).

According to the analysis of related databases, 72-40-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Schering Corporation; US2002/133006; (2002); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 72-40-2, name is 5-Amino-1H-imidazole-4-carboxamide hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 5-Amino-1H-imidazole-4-carboxamide hydrochloride

4-amino-5-imidazolecarboxamide hydrochloride was heated to reflux in phosphorus oxychloride for 3.5hs and after purification gave 4-amino-5-nitrile imidazole. This was resuspended in ethanol saturated with HCl overnight and purification gave 4-amino-5-ethylimino ester imidazole hydrochloride. This was combined with diphenylborinic acid ethanolamine ester in tetrahydrofuran (THF) overnight to yield the title compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 72-40-2.

Reference:
Patent; The Penn State Research Foundation; EP1420021; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 72-40-2, name is 5-Amino-1H-imidazole-4-carboxamide hydrochloride, molecular formula is C4H7ClN4O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: imidazoles-derivatives

(e) 4-({[3-Ethoxy-4-(2-ethoxyethoxy)pyridin-2-yl]methyl}amino)-lH-imidazole-5- carboxamide; NaCNBH3 (0.046 g, 0.73 mmol) was added in portions to a stirred solution of 5-amino-4- imidazolecarboxamide hydrochloride (0.150 g, 0.92 mmol) and 3-ethoxy-4-(2- ethoxyethoxy)pyridine-2-carbaldehyde (0.220 g, 0.92 mmol, obtained from Example 4(d)) in MeOH (1.5 mL) at r.t. over 10 minutes. The reaction mixture was stirred at r.t. for 2 days. The mixture was filtrated and the filtrate was evaporated in vacuo to give a crude of the title compound in quantitative yield. MS (ESI) m/z 364 (M +1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 72-40-2, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; WO2007/120098; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 72-40-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72-40-2 name is 5-Amino-1H-imidazole-4-carboxamide hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred suspension of 5-amino-I H-imidazole-4-carboxamide hydrochloride (1 Og, 0.061 5 mol) in acetonitrile (80 mL) was added diisopropylethylamine [DIPEA (12g. 0.0958 mol)] at room temperature. The reaction mixture was stirred at room temperature for 1 0mm followed by 4-nitrophenyl methylcarbamate (25g, 0.1270 mol) was added. The reaction mixture was stirred at room temperature for 24h. After consumption of starting material, the reaction mixture was filtered and the cake washed with acetonitrile (20 mL). The obtained solid was slurried in acetonitrile (80 mL), filtered and cake washed with acetonitrile (20 mE). The obtained solid dried at room temperature for 24h to afford 5-amino-NI-methyl-i H-imidazole1, 4-dicarboxamide (10 g) as an off white solid.?HNMR (DMSO-d6): 8.41 (q, 1H), 7.59 (s, 1H), 6.86 (bs, IH), 6.77 (bs, 1H), 6.35 (s, 2H), 2.78 (d, J 3.2 Hz. 3H);Mass (ni/z): 183.9 (M+); HPLC purity: 98.13%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-1H-imidazole-4-carboxamide hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; GRANULES INDIA LIMITED; VETUKURI, Prasada Raju VNKV; RAPOLU, Rajesh Kumar; NARAYANA, Rama Krishna Reddy; CHIGURUPATI, Krishna Prasad; CHATURVEDI, Akshay Kant; (20 pag.)WO2018/122724; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem