As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7189-69-7 name is 1,1′-Sulfonyldiimidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 7189-69-7
To a solution of compound Int-TG1-3 (530 mg, 1.2 mmol) in dry THF (25 ml) was added 1,1 ?-Sulfonyldiimidazole (477 mg, 2.4 mmol) and C52CO3 (196mg, 0.6 mmol). After 18hours under reflux, the mixture was quenched with 2 N aq. HC1 (100 mL). The organic layer was extracted with EtOAc (2 x 20 mL), dried over anhydrous Mg504, filtered and concentrated. The residue was purified by column chromatography to produce the compound Int-TG12 (396 mg, 58%).?H-NIVIR (400 MHz, CDC13) 5 7.84 (s, 1H), 7.35 (s, 1H), 7.34-7.3 1 (m, 1H), 7.20-7.16(m, 2H), 7.05 (t, 1H), 6.86 (m, 1H), 5.51-5.45 (m, 2H), 5.10 (dd, J = 3.6 Hz, 1H), 4.98 (d, J = 8Hz, 1H), 2.24 (s, 3H), 2.13(s, 3H), 2.07 (s, 3H), 2.04 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,1′-Sulfonyldiimidazole, and friends who are interested can also refer to it.
Reference:
Patent; INTOCELL, INC.; PARK, Taekyo; WOO, Sung Ho; KIM, Sunyoung; PARK, Suho; CHO, Jongun; JUNG, Doohwan; SEO, Donghoon; LEE, Jaeho; LEE, Sangkwang; YUN, Sanghyeon; LEE, Hyang Sook; PARK, Okku; SEO, Beomseok; (316 pag.)WO2019/8441; (2019); A1;,
Imidazole – Wikipedia,
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