Category: 716-79-0

Application of 716-79-0, A common heterocyclic compound, 716-79-0, name is 2-Phenyl-1H-benzo[d]imidazole, molecular formula is C13H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 28 mL of dimethyl sulfoxide was added 2.8 g (14 mmol, 1 equivalent) of 2-phenyl-1H-1,3-benzodiazole, 1.6 g (28 mmol, 2 eq.) Of potassium hydroxide, 0.12 g (0.72 mmol, 5 molpercent) of potassium iodide were sequentially added thereto, followed by cooling and stirring, 3.0 mL (28 mmol, 2 equivalents) of butane bromide was slowly added thereto, and the mixture was heated to room temperature and agitated for 4 hours. After completion of the reaction, 60 mL of water and 60 mL of ethyl acetate were added to the reaction mixture, After further washing with 60 mL of water, the solution was concentrated and purified by silica column chromatography to obtain 3.3 g (91percent) of 1-butyl-2-phenyl-1H-1,3-benzodiazole.

The synthetic route of 716-79-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samyang Co., Ltd.; Oh Cheon-rim; Lee Jae-hun; Kwon Jae-gwan; Lee Deuk-rak; Lee Won-jung; (17 pag.)KR2018/77354; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 716-79-0, name is 2-Phenyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 716-79-0, name: 2-Phenyl-1H-benzo[d]imidazole

Example 18 Preparation of Methyl 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetate (S18) To a suspension of 2-phenyl benzimidazole (0.32 g, 1.6 mmol) in acetonitrile (5 mL) was added caesium carbonate (0.80 g, 2.5 mmol) and methyl bromoacetate (0.16 mL, 1.7 mmol). The reaction mixture was stirred at room temperature for 3 hours and concentrated in vacuo. The residue was suspended in a mixture of CH2Cl2 and sat. NaHCO3 (vol percent 50:50, 15 mL). The aqueous layer was reextracted with CH2Cl2 (2 x 20 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated in in vacuo to afford the product (0.40 g, 1.5 mmol, 91 percent). 1H NMR (400 MHz, DMSO-d6) delta 7.77 – 7.63 (m, 3H), 7.63 – 7.44 (m, 4H), 7.33 – 7.09 (m, 2H), 5.21 (s, 2H), 3.64 (s, 3H). 13C NMR (101 MHz, DMSO-d6) delta 169.40, 153.91, 143.08, 136.91, 130.57, 130.51, 129.62, 129.53, 123.45, 123.00, 119.87, 111.36, 53.17, 46.57. LC-MS (ESI): calcd for C16H14N2O2: 267.11280 [M+H]+, found: 267.18 [M+H]+; HR-MS found 267.11311 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Waldmann, Herbert; Triola, Gemma; Wittinghofer, Alfred; Shehab, Ismail; Bastiaens, Philippe; Vartak, Nachiket; Papke, Bjoern; Zimmermann, Gunther; EP2698367; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 716-79-0, name is 2-Phenyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C13H10N2

The synthesis of 1-methyl-2-phenyl-1H-benzoimidazole (Mpb) is accomplished by referring to methods disclosed in Popov, 1. I., Chem. Heterocycl. Compd. (EN), 1996, 32, 6, p.672-681. The synthetic method is outlined in Scheme 1. To 20 mL acetone was added 2-phenyl-1H-benzoimidazole (1.94 g, 10 mmol), followed by the injection of iodomethane (1.42 mL, 12 mmol). The mixture was stirred at room temperature for 6 h, sodium hydroxide solution was then added, and the mixture reacted for an additional 5 min. The reaction mixture was extracted with dichloromethane. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography using n-hexanes/EA (v/v=80/20) as eluent. After the product was completely isolated, 1.03 mg (0.49 mmol) of the title compound was obtained (49percent yield). 1H NMR (CDCl3, delta): 3.87 (s, 3 H), 7.32-7.41 (m, 3 H), 7.51-7.56 (m, 3 H), 7.83-7.86 (m, 3 H).

According to the analysis of related databases, 716-79-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cheng, Chien-Hong; Chen, Ruey-Min; Guo, Hong-Ru; Chung, Jun-Wen; US2005/116626; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 716-79-0, name is 2-Phenyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 716-79-0, Recommanded Product: 2-Phenyl-1H-benzo[d]imidazole

General procedure: 2.5 g (12.88 mmol) of 2-phenyl-benzimidazole was dissolved in 30 ml of N,N-dimethylformamide, and 5.3 g (38.6 mmol) of K2CO3 and 2.0 ml (16.7 mmol) of 1-chloro-4-iodobutane were added to the resulting solution, followed by mixing the mixture at a room temperature for 10 hours. The reactant was combined with 100 ml of water and extracted with ethylacetate (70 ml X 5) being washed with water and a sodium hydroxide solution, and then the combined organic layer was dried over anhydrous sodium sulfate and filtered. The solvent was removed from the filtrate under a reduced pressure, and the resulting residue was refined by silica gel column chromatography (n-hexane/ethylacetate=2/1) to obtain 3.5 g (yield 96%) of the title compound.1H NMR (300MHz, CDCl3) delta 1.69(m, 2H), 2.00(m, 2H), 3.43(t, 2H), 4.29(t, 2H), 7.30-7.50(m, 3H), 7.55(m, 3H), 7.72(m, 2H), 7.83(m, 1H); MS(m/e, M+): 285

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Phenyl-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lim, Chae Jo; Kim, Nakjeong; Lee, Eun Kyoung; Lee, Byung Ho; Oh, Kwang-Seok; Yoo, Sung-Eun; Yi, Kyu Yang; Bioorganic and Medicinal Chemistry Letters; vol. 21; 8; (2011); p. 2309 – 2312;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 716-79-0, name is 2-Phenyl-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C13H10N2

4.3.1.8 2-Phenylbenzimidazole 13 Following general procedure A, exchange of 2-phenylbenzimidazole 13 (16.8 mg) in the presence of catalyst 1a (4.4 mg) gave [2′,6′-2H2]-13 (14.8 mg, 88percent, 84percentD). Following general procedure A, exchange of 2-phenylbenzimidazole 13 (16.8 mg) in the presence of catalyst 1b (4.6 mg) gave [2′,6′-2H2]-13 (14.9 mg, 89percent, 83percentD). Following general procedure A, exchange of 2-phenylbenzimidazole 13 (16.8 mg) in the presence of catalyst 1c (3.8 mg) gave [2′,6′-2H2]-13 (13.8 mg, 82percent, 72percentD). Following general procedure A, exchange of 2-phenylbenzimidazole 13 (16.8 mg) in the presence of catalyst 5 (3.4 mg) gave [2′,6′-2H2]-13 (15.3 mg, 91percent, 72percentD). deltaH (300 MHz, DMSO-d6) 12.90 (s, 1H), 8.19-8.17 (m, 2H), 7.60-7.47 (m, 5H), 7.23-7.18 (m, 2H).

The synthetic route of 716-79-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Atzrodt, Jens; Derdau, Volker; Kerr, William J.; Reid, Marc; Rojahn, Patrick; Weck, Remo; Tetrahedron; vol. 71; 13; (2015); p. 1924 – 1929;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 716-79-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 716-79-0 name is 2-Phenyl-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To the reaction vessel containing benzimidazole or imidazole (1mmol), alkyl halide (1mmol), 50percent NaOH (0.5mL) and anionic surfactant sodium dodecyl sulfate (5molpercent) was added and the reaction mixture was vigorously stirred at room temperature or 60°C. After the completion of reaction (TLC) followed by standard workup using ethyl acetate as extracting solvent the crude product was purified over silica-gel (60?120 mesh) using ethyl acetate?hexane (3:7) as eluent to afford pure products. Identities of the products were judged by the comparison of melting point, IR data, 1H NMR, 13C NMR and HRMS analyses.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Phenyl-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

Reference:
Article; Chakraborty, Ankita; Debnath, Sudipto; Ghosh, Tanmoy; Maiti, Dilip K.; Majumdar, Swapan; Tetrahedron; vol. 74; 40; (2018); p. 5932 – 5941;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 716-79-0, name is 2-Phenyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 716-79-0, category: imidazoles-derivatives

General procedure: A mixture of diazabicyclic olefin (50 mg, 0.2083 mmol,1.0 eqiuv), N-phenylpyrazole (30 mg, 0.2083 mmol, 1.0 eqiuv), [RuCl2(p-cymene)]2 (6 mg, 0.0104 mmol, 5.0 mol percent), and Cu(OAc)2H2O (62.46 mg,0.3123 mmol, 1.5 equiv) was weighed in a Schlenk tube and degassed for10 min. Dry toluene (2 mL) was added and the reaction mixture was purged with argon and allowed to stir at 110 °C for 12 h. The reaction mixture on silicagel column chromatography using mixtures of EtOAc?hexane yielded functionalized cyclopentene 3a in 73percent yield (58 mg).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Aparna; Prabha; Prakash, Praveen; Jijy; Luxmi Varma; Radhakrishnan; Tetrahedron Letters; vol. 55; 4; (2015); p. 865 – 868;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 716-79-0 as follows. Application In Synthesis of 2-Phenyl-1H-benzo[d]imidazole

General procedure: To a stirred solution of 2-phenyl-1H-benzo[d]imidazole 7a (50 mg, 0.26 mmol) and NaH (7 mg, 0.31 mmol) in DMF (0.5 mL) was added methyl bromoacetate (29 muL, 0.31 mmol) dropwise. After stirring at room temperature for 16 h, the reaction mixture was extracted with EtOAc (3 ~ 20 mL) and washed with H2O (~ 20 mL). The organic layer was dried over anhydrous MgSO4, and concentrated in vacuo. The residue was purified by column chromatography (SiO2, n-hexane/EtOAc 2/1) to yield the title product 8a (35 mg, 50percent). 1H NMR (300 MHz, CDCl3) delta ppm 7.87 (m, 1H) 7.72 (m, 2H) 7.54 (m, 3H) 7.35 (m, 3H) 4.93 (s, 2H) 3.82 (s, 3H); LC/MS (ESI+, MeCN/H2O): m/z: calcd for C15H13N2O2: 253.09 [M + H]+; found: 253.1.

According to the analysis of related databases, 716-79-0, the application of this compound in the production field has become more and more popular.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 716-79-0, Name is 2-Phenyl-1H-benzo[d]imidazole, molecular formula is C13H10N2, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Komori, K, once mentioned the new application about 716-79-0, Quality Control of 2-Phenyl-1H-benzo[d]imidazole.

Toward selectivity control of a heme peptide electrode by modification with a phase-transition polymer

Reduction currents for H2O2 at a heme peptide (HP)-modified electrodes are suppressed by inhibitors, such as imidazole derivatives. Although this inhibition effect allows determinations of the total inhibition ability of imidazole derivatives, it has no selectivity. In this study the selectivity control of HP-modified electrodes for imidazole derivatives was performed utilizing the thermoresponsive phase transition of poly(N-isopropylacrylamide), which was chemically immobilized on HP-modified electrodes. The inhibition ratios for imidazole derivatives appeared to be small at temperatures below the lower critical solution temperature (LCST), and to be large above the LCST. This change was ascribed to a steric hindrance caused by a phase transition of the polymer. On the other hand, the inhibition ratio for histamine, which has a larger molecular size relative to imidazole, was not significantly changed by the phase transition. Thus, the selectivity of the HP-modified electrode was found to be controllable using an immobilized phase-transition polymer.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 716-79-0. The above is the message from the blog manager. Quality Control of 2-Phenyl-1H-benzo[d]imidazole.

Synthetic Route of 716-79-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 716-79-0, Name is 2-Phenyl-1H-benzo[d]imidazole, SMILES is C1(C2=CC=CC=C2)=NC3=CC=CC=C3N1, belongs to imidazoles-derivatives compound. In a article, author is Hamidi, Zeinab, introduce new discover of the category.

Synthesis of polymer-supported Fe3O4 nanoparticles and their application as a novel route for the synthesis of imidazole derivatives

Cross-linked poly(4-vinylpyridine) supported Fe3O4 nanoparticles, abbreviated as [P-4-VP]-Fe(3)O(4)NPs, were easily prepared as a new magnetic polymeric catalyst and efficiently used for the synthesis of imidazole derivatives. The polymeric catalyst was characterized by using ofvarious techniques including field emission scanning electron microscopy, X-ray diffraction, vibrating sample magnetometry and Fourier transform infrared spectroscopy (FT-IR) techniques. According to the obtained results, good dispersion of Fe3O4 nanoparticles on the polymer-support and excellent magnetic property of the catalyst were achieved. Various methods have been reported for the synthesis of multi-substituted imidazoles by the reaction of benzil, aldehydes and amines or ammonium acetate in the presence of various catalysts. These methods have some disadvantages including long reaction times, non-reusability of the catalyst, polluted reaction conditions, effluent pollution, and low yields; therefore, we wish to report an efficient, fast, clean and green method for the synthesis of imidazole derivatives that has been developed by one-pot condensation reaction of benzil, ammonium acetate and aldehydes in the presence of [P-4-VP]-Fe3O4 nanoparticles. The catalyst displayed good catalytic activity when applied for the synthesis of imidazole derivatives. Various imidazole derivatives were prepared in high to excellent yields (68-99%) with short reaction time and high purity. The present procedure offers advantages such as short reaction time, simple reaction work-up, and the polymeric catalyst can be regenerated and reused several times without significant loss of its activity. [GRAPHICS] .

Synthetic Route of 716-79-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 716-79-0.