Category: 7152-24-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7152-24-1, name is 2-(Methylthio)benzimidazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-(Methylthio)benzimidazole

To a stirred solution of a benzimidazole g (beta.OOmmols) and p- fluoronitrobenzene h (6.00mmols) in 1OmL of anhydrous DMF, was added [potassium t-butoxide (f-BuOK) (7.61 mmols, 1.25eq.), and the reaction mixture was stirred at 80 0C overnight. The reaction mixture was added into 5OmL of water and the product was extracted with ethylacetate (3 x 2OmL). The extracts were washed with brine and concentrated. Column chromatography on silica gel using mixture of hexane:ethylacetate provided compound i in 25-45% yields.To a stirred solution of compound i (1.31 mmols) in 2OmL of 1 :1 CH2CI2IEtOH, was added SnCb (13.06mmols) followed by a few drops of water. The mixture was stirred overnight and concentrated. 2OmL of water was added to the residue, and the solution the brought to pH ~ 8-9 using 2N NaOH. The resulting mixture was extracted with ethylacetate (2OmL x 4), washed with brine (2OmL), dried over Na2SO-I, and concentrated to afforded compound j in 70-97% yields.To a solution of compound j (0.30mmols) in 5mL of CH2CI2, was added an acyl chloride k (0.30mmols), followed by diisopropyl-ethylamine (0.60mmols). The resultant mixture was stirred at room temperature for 30min and eluted through a short pad of silica gel using mixture of hexane:ethylacetate to afford, upon concentration, the product I in 80-96% yields.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7152-24-1.

Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; WO2007/112093; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7152-24-1, name is 2-(Methylthio)benzimidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 2-(Methylthio)benzimidazole

General procedure: A mixture of KOH and 2-methylmercaptobenzimidazole was stirred in DMF at room temperature for 1 h. The dibromo compound was added to the above reaction mixture was allowed to stir continuously at room temperature for 24 h. The reaction was quenched by adding water. The resulting powder was collected by filtration and was dried.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Rajakannu, Palanisamy; Elumalai, Palani; Mobin, Shaikh M.; Lu, Kuang-Lieh; Sathiyendiran, Malaichamy; Journal of Organometallic Chemistry; vol. 743; (2013); p. 17 – 23;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem