Category: 7098-07-9

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7098-07-9 as follows. 7098-07-9

General procedure: To a vigorously stirred solution of imidazole derivatives (23.39mmol) in dry toluene (10mL) at room temperature was added the solution of chloromethyl-salicylaldehydes 2a, b (19.50mmol) in dry toluene (10mL), drop-wise, under nitrogen atmosphere. The resulting solution was further stirred at 60°C for 24h. The product separated out was washed twice with toluene (2×5mL) and several times with ether (5×10mL), to remove the unreacted materials, and dried under vacuum to give pale yellow solid which used for the following preparations without further purification. Samples of the products were nevertheless isolated and fully characterized, as described below.

According to the analysis of related databases, 7098-07-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Elshaarawy, Reda F.M.; Janiak, Christoph; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 31 – 42;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 7098-07-9, A common heterocyclic compound, 7098-07-9, name is 1-Ethyl-1H-imidazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 100 mL three-necked flask, TMEDA (2.86 g, 3.72 ml, 24.7 mmol, Eq: 2.37) was combined with pentane (10 ml) to give a colorless solution. N-BuLi 1.6M in hexane (15.6 ml, 25.0 mmol, Eq: 2.4), followed by 1-ethyl-1H-imidazole (1 g, 10.4 mmol, Eq: 1.00) were added dropwise at -25° C. for 30 min. The reaction mixture was stirred at RT for 1 h (light yellow suspension). Afterwards, the suspension was cooled to -65° C. and THF anhydrous (30 ml) was added (-65° C. to -48° C.). A solution of iodine (3.83 g, 15.1 mmol, Eq: 1.45) in THF anhydrous (20 ml) was added dropwise to the reaction mixture (internal temperature remained below -55° C.)=>brown suspension. Stirring was continued as the reaction was gradually warmed to 0° C. during 1.3 hours (brown milky solution). Eventually, the reaction was quenched by adding 4 mL of methanol. Work up: The reaction mixture was poured into 50 mL sat. Na2SO3 and extracted with EtOAc (2*100 mL). The organic layers were combined, washed with brine, dried over Na2SO4, and concentrated i. V. Purification: The crude material was purified by flash chromatography (silica gel, 50 g, 20percent to 100percent EtOAc in heptane) to provide in the more polar fractions 417 mg of the desired title compound as yellow oil. MS (ESI): 222.9 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; HOFFMANN-LA ROCHE INC.; Aebi, Johannes; Amrein, Kurt; Hornsperger, Benoit; Kuhn, Bernd; Maerki, Hans P.; Mayweg, Alexander V.; Mohr, Peter; Tan, Xuefei; US2014/128429; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 7098-07-9, name is 1-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7098-07-9, Quality Control of 1-Ethyl-1H-imidazole

A mixture of CoCl26H2O (0.1705 g, 0.8 mmol), NH4VO3(0.1404 g, 0.8 mmol), eIM (0.8 mL), and H2O (8 mL) was heated at about 120 °C for 72 h. After the mixture was cooled to room temperature, dark purple crystals were isolated from the mixture. Yield: 62percent (based on NH4VO3); Anal. Calcd. for C30H52Co2N12O14V4(percent): C, 31.96; H, 4.61; N, 14.91. Found: C, 31.71; H, 4.42; N, 14.58.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Ethyl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Article; Niu, Yan-Hong; Yang, Song; Li, Ji-Kun; Xu, Yan-Qing; Hu, Chang-Wen; Chinese Chemical Letters; vol. 27; 5; (2016); p. 649 – 654;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 7098-07-9,Some common heterocyclic compound, 7098-07-9, name is 1-Ethyl-1H-imidazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A generic experimental procedure is described: N-substituted imidazoles 1-6 (1 mmol equivalent) and 2,6-bis(chloromethyl)pyridine 7 (0.5mmol equivalent for each compound, m.p 73-78 °C; ALDRICH) were mixed together under inert condition in a 50 ml round bottom flask with gentle stirring. The temperature was then gently raised to 60 °C; giving a molten substance that was allowed to continue stirring for 16 h at 60 °C. The resultant grey or light brown crude solid was allowed to cool to room temperature and loaded onto a short plug of silica. Unreacted starting materials are rinsed-out with ethyl acetate while the salts were obtained (Rf value 0.01) as methanol (100percent) eluents. Solvent is then removed under reduced pressure to yield pure imidazolium salts 8-13.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Ethyl-1H-imidazole, its application will become more common.

Reference:
Article; Ibrahim, Halliru; Bala, Muhammad Dabai; Tetrahedron Letters; vol. 55; 46; (2014); p. 6351 – 6353;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7098-07-9, name is 1-Ethyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H8N2

General procedure: As a general procedure for preparing Bronsted acidic ILs, the synthesis of 1-(4-butylsulfonic)-3-ethylimidazolium hydrogensulfate ([EImC4SO3H][HSO4]) is given as an example. To 1-ethylimidazole (10 g, 0.104 mol) in 50 mL of toluene, 1,4-butanesultone (14.2 g, 0.104 mol) dissolved in 50 mL of toluene was added dropwise under a dry nitrogen gas atmosphere. The resulting solution was refluxed with stirring at 60 °C for 24 h.After removing toluene, the product was washed thrice with 100 mL of diethyl ether to yield 1-(4-butylsulfonate)-3-ethylimidazol([EImC4SO3]) as a white powder. After dissolving [EImC4SO3] (20 g, 8.6102 mol) in 50 mL of methanol, sulfuric acid (0.84 g, 8.6102 mol) was added dropwise in an ice bath. The resulting solution was refluxed with stirring at 60 °C for 24 h. Following the reaction, methanol was removed by evaporation and then under reduced pressure, giving1-(4-butylsulfonic)-3-ethylimidazolium hydrogen sulfate ([EImC4SO3H][HSO4]) as a viscous liquid.

According to the analysis of related databases, 7098-07-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kakibe, Takeshi; Nakamura, Satoshi; Amakuni, Kiyokazu; Kishi, Hajime; Australian Journal of Chemistry; vol. 72; 2; (2019); p. 101 – 105;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 7098-07-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7098-07-9, name is 1-Ethyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

As a general procedure for preparing Bronsted acidic ILs, the synthesis of 1-(4-butylsulfonic)-3-ethylimidazolium hydrogensulfate ([EImC4SO3H][HSO4]) is given as an example. To 1-ethylimidazole (10 g, 0.104 mol) in 50 mL of toluene, 1,4-butanesultone (14.2 g, 0.104 mol) dissolved in 50 mL of toluene was added dropwise under a dry nitrogen gas atmosphere. The resulting solution was refluxed with stirring at 60 °C for 24 h.After removing toluene, the product was washed thrice with 100 mL of diethyl ether to yield 1-(4-butylsulfonate)-3-ethylimidazol([EImC4SO3]) as a white powder. After dissolving [EImC4SO3] (20 g, 8.6102 mol) in 50 mL of methanol, sulfuric acid (0.84 g, 8.6102 mol) was added dropwise in an ice bath. The resulting solution was refluxed with stirring at 60 °C for 24 h. Following the reaction, methanol was removed by evaporation and then under reduced pressure, giving1-(4-butylsulfonic)-3-ethylimidazolium hydrogen sulfate ([EImC4SO3H][HSO4]) as a viscous liquid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Ethyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kakibe, Takeshi; Nakamura, Satoshi; Amakuni, Kiyokazu; Kishi, Hajime; Australian Journal of Chemistry; vol. 72; 2; (2019); p. 101 – 105;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7098-07-9, name is 1-Ethyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 7098-07-9

1-Ethyl-2-iodo-1H-imidazole ; [Show Image] (1) To a solution of 1-ethyl-1H-imidazole (2.844 g) in THF (60 ml), n-BuLi (11.6 ml, 2.59 N in hexane) was added dropwise at -78C under an argon atmosphere. After stirring at the same temperature for 30 minutes, a solution of I2 (7.614 g) in THF (25 ml) was added dropwise. The reaction mixture was warmed to room temperature, diluted with saturated aqueous sodium bicarbonate, and extracted with AcOEt. After washing with saturated aqueous Na2S2O3, the organic layer was dried over MgSO4, filtered and then evaporated to remove the solvent, thereby giving the titled compound (6.492 g) as a light-yellow solid. 1H NMR (200 MHz, CDCl3) delta ppm: 1.40(t,J=7.4Hz,3H), 3.95(q,J=7.4Hz,2H), 7.02-7.06(m,1H), 7.07-7.11(m,1H

The synthetic route of 7098-07-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD; EP1988081; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7098-07-9, name is 1-Ethyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: imidazoles-derivatives

The reaction end point was monitored by adding 6.16 g (10 mmol) of M1 ‘, 0.96 g (10 mmol) of 1-ethyl tasteless, 50 mL of acetonitrile at room temperature for 48 h in a dry 100 mL three-necked flask. Washed with petroleum ether (100 mL x 3), the resulting viscous liquid was again Washed with ether (100 mL x 3) to give a yellow solid, Recrystallization from methylene chloride and drying in vacuo for 24 h afforded a pale yellow solid As the target compound (B2), 7.1 g, and the yield was 99percent.

The synthetic route of 7098-07-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Central China Normal University; Zhang Aidong; Zhang Tiejiang; Duan Jiang; Tu Haiyang; (22 pag.)CN107188869; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7098-07-9, name is 1-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., Product Details of 7098-07-9

1,4-butane sultone(14. 98 g, 0.1 mol) was slowly added to a solution of N-ethylimidazole (9. 61 g,0. 1 mol) for 28 h stirring, temperature control 30 ° C, the reactants into solid,Washed thoroughly with ether and dried in an infrared oven. Take the above solid 7. 88g in a three-necked flask,The aqueous solution of periodic acid (9.12 g, 0.04 mol) was slowly added and stirred at 90 ° C for 18 h,Vacuum steam separation to obtain [HSO3-BEIM] IO4 | ionic liquid oxidant.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; China Petroleum and Chemical Corporation; China Petroleum and Chemical Corporation,Petrochemical Research Institute; ZHAO, JUNQI; CHENG, SHIBIAO; MU, XUHONG; ZONG, BAONING; DING, JING; DAI, WEILIN; (17 pag.)CN106279035; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7098-07-9, name is 1-Ethyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H8N2

(1) in the equipped with a stirrer,thermometer,Calcium chloride drying tube and dropping funnel500 ml four-necked flask6.10 g (0.05 mol) of 1,3-propanesultone and150 mL of ethyl acetate was added and the mixture was stirred1,3-propane sultone dissolved,The flask was heated in an oil bath equipped with methyl silicone oil70 ° C,Slowly drop dissolved(0.065 mol) of N-ethylimidazole50 mL of ethyl acetate was added dropwise(Dropwise addition time: 30 min)Insulation reaction 2h,Pressure filtration,The residue was washed with ethyl acetate,Vacuum drying,To give 1- (3-sulfopropyl) -3-ethylimidazolium salt (EIm-PS)10.20 g,The yield was 93.6percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7098-07-9.

Reference:
Patent; Guangxi Kemao Forest Chemical Co., Ltd.; Jiangxi Jinan Forest Products Industrial Co., Ltd.; Guangdong Komo Co., Ltd.; Weng, Liang; Xu, Sheyang; Chen, Jiuji; (16 pag.)CN104926664; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem