Category: 693-98-1

Reference of 693-98-1,Some common heterocyclic compound, 693-98-1, name is 2-Methyl-1H-imidazole, molecular formula is C4H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Aryl halide (1.0mmol), amine (1.5-2.0mmol), PNP-SSS (0.6mol%; 0.023g), K2CO3 (2mmol), and DMF (3.0mL) was placed in a 25mL flask equipped with a magnetic stirring bar and heated at 120C under nitrogen gas. The reaction was then monitored by TLC until the consumption of aryl halide was detected. After completion of the reaction 5mL of water and 5mL of ethyl acetate were added to the reaction mixture. The organic solution was extracted and dried over anhydrous Na2SO4. After removing of organic solvent the crude product was obtained. For further purification the chromatography technique was used.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methyl-1H-imidazole, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 693-98-1, name is 2-Methyl-1H-imidazole, A new synthetic method of this compound is introduced below., COA of Formula: C4H6N2

General procedure: To a solution of N-heterocycle (1 equiv), bromobenzene (1.02 equiv) and tBuOK (2 equiv) in dry DMF, CuFe2O4 (10 mol percent) was added and heated at reflux for 24 h under N2 atmosphere. After cooling to room temperature, the mixture was diluted with ethyl acetate and the catalyst was separated by a magnetic separator. The catalyst was washed with ethyl acetate. The combined ethyl acetate layer was washed with water (twice), dried over anhydrous Na2SO4, and concentrated to yield the crude product, which was further purified by silica gel column chromatography using petroleum ether/ethyl acetate to yield N-arylated product.

The synthetic route of 693-98-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Panda, Niranjan; Jena, Ashis Kumar; Mohapatra, Sasmita; Rout, Smruti Ranjan; Tetrahedron Letters; vol. 52; 16; (2011); p. 1924 – 1927;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 693-98-1, Name is 2-Methyl-1H-imidazole, molecular formula is C4H6N2. In an article, author is Marzouk, Adel A.,once mentioned of 693-98-1, Computed Properties of C4H6N2.

Design, synthesis and anticonvulsant activity of new imidazolidindione and imidazole derivatives

New imidazolidindiones and tetra-substituted imidazole derivatives were designed, synthesized, and evaluated for the anticonvulsant activity through pentylenetetrazole (PTZ)-induced seizures and maximal electroshock (MES) tests using valproate sodium and phenytoin sodium as reference drugs, respectively. Most of the target compounds showed excellent activity against pentylenetetrazole (PTZ)-induced seizures with fair to no-activity against MES. Compounds 3d, 4e, 11b, and 11e showed higher activity (120%) than that of valproate sodium in PTZ model. Almost all compounds showed no neurotoxicity, as indicated by the rotarod test. Estimation of physicochemical properties and pharmacokinetic profiles of the target compounds were studied. The chemical structures of the target compounds were characterized by different spectrometric methods and elemental ana-lysis.

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Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 693-98-1, Name is 2-Methyl-1H-imidazole, SMILES is CC1=NC=CN1, belongs to imidazoles-derivatives compound. In a document, author is Huang, Jiangkun, introduce the new discover, Application In Synthesis of 2-Methyl-1H-imidazole.

Novel synthesis of divergent aryl imidazoles from ketones involving copper-catalyzed alpha-amination and oxidative C-C bond cleavage

A one-pot synthesis, initiated by a copper salt with inorganic (NH4)(2)CO3 as the nitrogen source, forms divergent aryl imidazole derivatives from ketones via alpha-amination and oxidative C-C bond cleavage reactions. The approach provides a simple and rapid synthesis of imidazole derivatives and has certain versatility.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 693-98-1 is helpful to your research. Application In Synthesis of 2-Methyl-1H-imidazole.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 693-98-1, Name is 2-Methyl-1H-imidazole, molecular formula is C4H6N2. In an article, author is Aleksandrova, E. V.,once mentioned of 693-98-1, COA of Formula: C4H6N2.

REACTIONS OF HALONITROIMIDAZOLES WITH NUCLEOPHILES (REVIEW)

Published data on the reactions of 4(5)-halo-5(4)-nitro- and 2-halo-4(5)-nitroimidazoles with nucleophiles are reviewed and classified.

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Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 693-98-1, Name is 2-Methyl-1H-imidazole, molecular formula is C4H6N2, belongs to imidazoles-derivatives compound. In a document, author is Gupta, Namita, introduce the new discover, Recommanded Product: 2-Methyl-1H-imidazole.

Synthesis and Evaluation of N-substituted Imidazole Derivatives for Antimicrobial Activity

A series of N-substituted imidazole derivatives was synthesized. Imidazole nucleus was reacted with ethylchloroacetate to form imidazole ester. Reaction of the imidazole ester (I) with different amines yields the desired products (1a-1e). The compounds were characterized by FT-IR, H-1-NMR and mass spectra. The synthesized compounds were evaluated for the antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger by determination of MIC (minimum inhibitory concentration) using tube dilution method. Compound (1b) was found to be the most active antimicrobial compound amongst others in the series.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 693-98-1. Recommanded Product: 2-Methyl-1H-imidazole.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 693-98-1, Name is 2-Methyl-1H-imidazole. In a document, author is ABDALLA, EM, introducing its new discovery. Recommanded Product: 693-98-1.

NEW LIGHT ON MOLECULAR-COMPLEXES OF IMIDAZOLES WITH IODINE

Charge-transfer molecular complexes of some imidazole derivatives (D) with the sigma-electron acceptor iodine have been synthesized and characterized. The spectral characteristics and stability of the complexes have been examined and are discussed in terms of the nature of the imidazole derivatives. The 1:1 formed complexes exist mainly in solution or in the solid state in the ionic form D2I+.I3-. This ionic structure is thought to be produced by ionization of the 1:1 molecular complex as represented by the equation 2D-I2 –> D2I+.I3-.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 693-98-1 help many people in the next few years. Recommanded Product: 693-98-1.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 693-98-1, Name is 2-Methyl-1H-imidazole, SMILES is CC1=NC=CN1, belongs to imidazoles-derivatives compound. In a document, author is Guijarro, Albert, introduce the new discover, Recommanded Product: 693-98-1.

Isoprene-mediated lithiation of imidazole derivatives: mechanistic considerations

The isoprene-mediated lithiation, with lithium metal, of different imidazole derivatives is an interesting methodology for their functionalization. Studies of different possible intermediates involved in the reaction employing density functional theory calculations, at the B3LYP/6-311++G(d,p) level are considered. A plausible mechanism is described, in which isoprene is reduced, to the corresponding radical anion, in the presence of Li-(s), acting then as a base deprotonating N-methylimidazole (NMI) and producing the 1,1-dimethylallyl radical. This radical is further reduced by the excess of lithium proceeding once more as a base. This final step produces stable final products that compensate the previous equilibriums, making favourable the whole process.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 693-98-1 is helpful to your research. Recommanded Product: 693-98-1.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 693-98-1, Name is 2-Methyl-1H-imidazole. In a document, author is Jamaledini, Azar, introducing its new discovery. Product Details of 693-98-1.

A practical one-pot three-component procedure for preparation of 3a,8a-dihydroxyindeno[1,2-d]imidazole derivatives in aqueous ethanol

The results of our investigations on the preparation of 3a,8a-dihydroxyindeno[1,2-d]imidazole derivatives via reaction of thiourea, ninhydrin, and alkyl/benzyl chlorides in aqueous ethanol and under convenient conditions is reported. On the other hand, when guanidinium chloride was used instead of thiourea, the reaction mixtures reached with unexpected products; 2,2-dialkoxy-1H-indene-1,3(2H)-diones.

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Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 693-98-1, Name is 2-Methyl-1H-imidazole, molecular formula is , belongs to imidazoles-derivatives compound. In a document, author is Zhang, Feifei, Category: imidazoles-derivatives.

A practical and green approach towards synthesis of multisubstituted imidazoles using boric acid as efficient catalyst

An efficient one-pot’ cyclocondensation of ammonium acetate, 7 2-diphenyl ethanedione, aromatic aidehyde or arylamine, and catalyzed by boric acid is achieved to form multisubstituted imidazole derivatives. Boric acid as green property is harmless to the environment has improved the yield of multisubstituted imidazole derivatives. Moreover, we have tested the biological activities of imidazole derivatives by the four fungi. And the investigations showed most of imidazole derivatives have antifungal action on four fungus.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 693-98-1, in my other articles. Category: imidazoles-derivatives.