Category: 68892-07-9

Adding a certain compound to certain chemical reactions, such as: 68892-07-9, name is Methyl 2-mercapto-1-methyl-1H-imidazole-5-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68892-07-9, category: imidazoles-derivatives

428 g (2.49 mol) of the commercially available compound (XXIII) were stirred in 2.81 of 3 M aqueous sodium hydroxide solution at 15 C. for 30 mm. Using 6hydrochloride acid, the pH was then adjusted to 1-2 and the precipitate was filtered off with suction. Drying gave 363of the compound (XXIV). 1H-NMR (400 MHz, CD3OD): oe=3.82 (s, 3H),7.58 (s, 1H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-mercapto-1-methyl-1H-imidazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; FISCHER, REINER; HEIL, MARKUS; JANSEN, JOHANNES-RUDOLF; KUEBBELER, SUSANNE; WILCKE, DAVID; KOEHLER, ADELINE; WILLOT, MATTHIEU; EILMUS, SASCHA; ILG, KERSTIN; MALSAM, OLGA; LOESEL, PETER; PORTZ, DANIELA; ANDERSCH, WOLFRAM; (92 pag.)US2018/7900; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68892-07-9, name is Methyl 2-mercapto-1-methyl-1H-imidazole-5-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 68892-07-9

A solution of compound 1 (300.0 mg, 1.74 mmol) in a NaOH solution (2.0 M, 4.0 mL, 8.0 mmol) in water (4.0 mL) was stirred at 20 C for 4 h. The solution was adjusted to pH = 2.0with conc. HC1 solution. The precipitate formed was collected by filtration, and dried in vacuo to afford Compound 2 (200 mg, 1.264 mmol, 72.6% yield) as a white solid. ?H NMR (400 MHz, DMSO-d6) 5 12.76 (s, 1H), 7.69 (d, J= 2.4 Hz, 1H), 3.68 (s, 3H). LCMS showed most product was dimer. LCMS (5-95AB/1.5min): RT = 0.807 mi [M+Hjb 158.7, dimer: [M+ljb 314.9.

According to the analysis of related databases, 68892-07-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; DRAGOVICH, Peter; PEI, Zhonghua; PILLOW, Thomas; SADOWSKY, Jack; CHEN, Jinhua; WAI, John; (237 pag.)WO2017/64675; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

68892-07-9, name is Methyl 2-mercapto-1-methyl-1H-imidazole-5-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of Methyl 2-mercapto-1-methyl-1H-imidazole-5-carboxylate

To a mixture of example 159 (60 mg, 0.125 mmol, 1 equiv), methyl 2-mercapto-l-methyl-lH-imidazole-5-carboxylate (30.2 mg, 0,176 mmol, 1.4 equiv) and PPh3 (46.2 mg, 0.176 mmol. 1.4 equiv) in toluene (0.35 mL) at 0 C was added dropwise diethyl azodicarboxylate (40 % wt in toluene, 80 muEpsilon, 0, 176 mmol. 1.4 equiv). The mixture was stirred at rt for 3 h, concentrated, and then purified by column to give 79 mg (100%) of intermediate 161a as a white solid.

The synthetic route of 68892-07-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew; WO2013/96771; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem