Category: 68468-39-3

Related Products of 68468-39-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68468-39-3, name is 5-Bromo-1H-benzo[d]imidazole-2(3H)-thione belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Description 19: S-Bromo-lH-benzoimidazole^-sulfonic acid; [00281] Thiocarbonyl diimidazole (0.95 g, 5.35 mmol) was added in one portion to a solution of 4-bromobenzene-l,2-diamine (1.00 g, 2.67 mmol) in TetaF (50 mL). The mixture was stirred for 6 h then the solvents were removed in vacuo. The residue was suspended in DCM and the product was collected by filtration as a white solid. This was dissolved in KOeta solution (IM, 10.7 mL, 10.7 mmol) and eta2O2 (30 %, 2.13 mL, 21.40 mmol) was added dropwise. The mixture was stirred for 14 h then concentrated HCl was added to pH 1. The mixture was cooled to 0 0C for 30 min then the white solid product was collected by filtration. This was dried at 40 0C under high vacuum (1.15 g, 77 %). MS (MH+, m/z) 275 (50 %), 277 (50 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1H-benzo[d]imidazole-2(3H)-thione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS N.V.; WO2008/55959; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 68468-39-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68468-39-3, name is 5-Bromo-1H-benzo[d]imidazole-2(3H)-thione belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 2,4-Dinitrochlorobenzene (1 mmol), 2-mercapto-5-substituted benzimidazoles (1 mmol) and Potassium hydroxide (1 mmol) were suspended in aqueous-EtOH (1:1). The reaction mixture was stirred vigorously for about 30 minutes and then refluxed on water bath for 2.5 h, at which point it cleared and TLC analysis indicated complete consumption of the reactants. The reaction mixture was diluted with 50 mL of water and cooled in ice, and the precipitate was collected by filtration. After being washed with cold water (2 x 25 mL), the precipitate was dried under vacuum to afford a pure product (3a-d).

The synthetic route of 5-Bromo-1H-benzo[d]imidazole-2(3H)-thione has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kankala, Shravankumar; Kankala, Ranjith Kumar; Gundepaka, Prasad; Thota, Niranjan; Nerella, Srinivas; Gangula, Mohan Rao; Guguloth, Hanmanthu; Kagga, Mukkanti; Vadde, Ravinder; Vasam, Chandra Sekhar; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1306 – 1309;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem