Category: 68282-53-1

68282-53-1, Adding some certain compound to certain chemical reactions, such as: 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68282-53-1.

COMPOUND 12.1. 20: 4- {5. 8-DIMETHOXY-2-rf4-METHYL-l-IMIDAZOL-5- YL)METHYL]-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL}-N,N- DIETHYLBENZAMIDE; INTERMEDIATE 5.1. 10 (115 mg, 0.31 mmol) and 4-methyl-5- imidazolecarbaldehyde (108 mg, 0.62 mmol) were dissolved in DCE (5.0 mL). After stirring for 10 min at room temperature, sodium triacetoxyborohydride (197 mg, 0.93 mmol) was added and the mixture was stirred for 18 h at room temperature. DCM and 1 M sodium hydroxide solution were added and the mixture was passed through a Whatman 1PS silicon-treated filter paper. The organic phase was evaporated and the crude product was purified by flash chromatography to yield the product (103 mg, 0. 20 mmol, 65%).’H NMR (500 MHz, CDC13) : 8 0. 99, 1.18 (2 brs, 6H), 2.58-2. 74, 3.17-3. 50 (2 m, 8H), 3.32, 3.35 (2 s, 6H), 3.44, 3.65 (2 d, J 12.0 Hz, 2H), 5.05 (s, 1H), 6.51, 6.63 (2 d, J 9. 0 Hz, 2H), 6.87 (s, 1H), 7.00, 7.14 (m, 4H), 7. 21 (m, 5H), 7.80 (d, J 3. 5 Hz, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 68282-53-1.

Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

68282-53-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

Example 20 (0253) (rac)-2,4-bis((jE)-2-(4-methyl-lH-imidazo-5-yl)vinyl)-6,7 0 i-tetrahydro- dipyrido[2,l- a:l’,2T-k][2,9]phenanthroHne-5,12-diium trifluoromethanesulfonate, HTA-C5-11Starting racemic helquat O (10.0 mg, 16.3 mupiiotaomicron), 1 -methyl- lH-pyrrole-2-carbaldehyde (57 mg, 522 mupiiotaomicron), pyrrolidine (22 mu, 261 mupiiotaomicron) and dry methanol (0.5 ml) were placed into a 10 ml flask and the resulting mixture was stirred under argon for 1 h at room temperature. Progress of the reaction was monitored by thin layer chromatography. The crude product was precipitated from the reaction mixture by addition of diethylether (5 ml). The suspension was centrifuged and the supernatant was separated from the solid pellet. The solids were dissolved in methanol (0.5 ml) and the pure product was precipitated by addition of diethylether (5 ml). The same procedure was repeated with tetrahydrofuran (0.5 ml) – diethylether (5 ml) and acetonitrile (0.3 ml) – diethylether (5 ml). Then, centrifugation of this suspension, removal of the supernatant and drying of the solid part under vacuum of an oil pump led to 10.1 mg (12.7 muiotaetaomicron, 78 % yield) of dark-yellow solid HTA-C5-1 1. (0255) (0256) NMR (400 MHz, acetonitrile-d3): 2.32 (s, 3H), 2.46 (s, 3H)5 3.12-3.43 (m, 4H), 4.27-4.31 (m, 1H), 4.80-4.88 (m, 2H), 5.05 (m, 1H), 7.01 (d, J= 16.04 Hz, 1H), 7.44-7.52 (m, 4H)} 7.62-7.76 (m, 4H), 7.83-7.96 (m, 2H), 8.13-8.17 (m, 1H), 8.026 (d, J= 1.96 Hz, 1H), 8.77 (dd, J= 2.12, 6.32 Hz, 1H), 10.38 (broad s, 2H for -NH).

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Reference:
Patent; USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.; VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE; TEPLY, Filip; HAJEK, Miroslav; KUZMOVA, Erika; KOZAK, Jaroslav; KOMARKOVA, Veronika; HUBALKOVA, Pavla; REYES-GUTIERREZ, Paul Eduardo; JIRASEK, Michael; SONAWANE, Monoj R.; JOSHI, Vishwas D.; SEVERA, Lukas; NOVOTNA, Jana; WO2015/180701; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem