Category: 67768-61-0

Related Products of 67768-61-0,Some common heterocyclic compound, 67768-61-0, name is 1-Cyclohexyl-1H-imidazole, molecular formula is C9H14N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,4,5-tribromo-1-cyclohexyl-1H-imidazole (12.2.). N-bromosuccinamide (1.78 g, 9.99 mmol) dissolved in CHCl3 (4 ml) at 0 C. was added to a 4 ml solution of 12.1 (500 mg, 3.33 mmol) in CHCl3. The mixture was stirred at rt for 17 h, filtered, concentrated, and the crude residue stirred in ether for 30 min. Filtration and concentration gave a crude product which was purified by SiO2 chromatography (10% EtOAc/hexanes) to afford 267 mg (21%) 12.2. MS (ESI) 385.0 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Cyclohexyl-1H-imidazole, its application will become more common.

Reference:
Patent; Glunz, Peter W.; Douty, Brent D.; Martin, Scott W.; Romine, Jeffrey; US2005/75376; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 67768-61-0, name is 1-Cyclohexyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67768-61-0, HPLC of Formula: C9H14N2

D) 1,1′-Dicyclohexyl-3,3′-methylenediimidazolium diiodide 11 0.0065 mol of diiodomethane (1.741 g; 0.52 ml) and 5 ml of tetrahydrofuran are added to 0.013 mol of cyclohexylimidazole (2.000 g) in an ACE pressure tube. The reaction mixture is stirred at 80 C. for 3 hours. The solid which precipitates is washed repeatedly with a little tetrahydrofuran. The white solid 11 is obtained. Empirical formula: C19H30N4I2 M=568.270 g/mol Yield: 0.891 g (24.1% of theory) Melting point: decomposition at >286 C. 1H (ppm, d6-DMSO, 300.13 MHz): delta=9.45 (s, 2H, NCN); 8.01 (dd, 4H, J=1.6 Hz, NCCN); 6.58 (s, 2H, NC2N); 4.36 (t, 2H, J=11.7 Hz, C of cyclohexyl ring); 2.09 (d, 4H, J=9.7 Hz, C2 of cyclohexyl ring); 1.85 (d, 4H, J=13.3 Hz, C2 of cyclohexyl ring); 1.68 (d, 4H, J=12.3 Hz, C2 of cyclohexyl ring); 1.40 (quart, 4H, J=12.7 Hz, C2 of cyclohexyl ring); 1.23 (t, 4H, J=12.5 Hz, C2 of cyclohexyl ring)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Cyclohexyl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Patent; BASF SE; TECHNISCHE UNIVERSITAET DRESDEN; US2009/326237; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem